Drugs as anti‐nutrients

Gingival Bleeding and Bloody Dialysate: A Case Report of Scurvy in a Child With End-Stage Renal Disease Receiving Peritoneal Dialysis

“…12,20,21 Several drugs act as antinutrients, by causing deficiency in essential substances, or by interfering with their functions. 22 In particular, the patients with ESRD are frequently prescribed several medications as well as multivitamins and minerals supplement. The multiple drug uses increase the risk for drug-nutrient interactions in these patients.…”

Raising awareness of drug‐micronutrient interactions

“…However, as antinutrients, they interfere with the absorption of fat-soluble vitamins (A, D, E and K) in addition to carotenoids, iron and vitamin B9 (folate). 3,6,11 Therefore, NICE advises that supplementation with vitamins A, D and K along with folic acid may be required when bile acid sequestrant treatment is prolonged. 41 There is no recommendation for vitamin E supplementation, and it is interwchh.onlinelibrary.wiley.com esting to note that substantial reports of iatrogenic vitamin E deficiency appear to be rare.…”

“…19 Depending on the antiepileptic drug, vitamins B12, B6 (pyridoxine) and B7 (biotin), along with vitamin B9 (folate), may also be depleted. 6,10 In fact, MHRA advice published in January 2021 states that all women using antiepileptic drugs who are planning a pregnancy should be offered high-dose folic acid (5mg daily) preconception. 43…”

“…2 Many of these also happen to be micronutrients at risk of depletion by commonly prescribed drugs (see Table 1), which may affect micronutrient absorption, metabolism, utilisation or excretion. [3][4][5][6]…”

Food and Drug Interactions: A General Review

“…Some individuals are more susceptible to loss of nutrients than others, and they are more likely to suffer from side effects [Moss 2007].…”