“…However, as antinutrients, they interfere with the absorption of fat-soluble vitamins (A, D, E and K) in addition to carotenoids, iron and vitamin B9 (folate). 3,6,11 Therefore, NICE advises that supplementation with vitamins A, D and K along with folic acid may be required when bile acid sequestrant treatment is prolonged. 41 There is no recommendation for vitamin E supplementation, and it is interwchh.onlinelibrary.wiley.com esting to note that substantial reports of iatrogenic vitamin E deficiency appear to be rare.…”