Drugs and HPA axis

Ambrogio, Alberto Giacinto; Giraldi, Francesca Pecori; Cavagnini, Francesco

doi:10.1007/s11102-008-0114-6

Cited by 28 publications

(33 citation statements)

References 179 publications

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“…As drugs such as antidepressants and those prescribed for Cushing's syndrome can impair the laboratory assessment of HPA axis activity (14), subjects with drug or alcohol abuse problems or prescribed medication intake were excluded from the study. The study protocol was approved by the ethics committee of Faculdade de Odontologia, Universidade de São Paulo.…”

Section: Methodsmentioning

confidence: 99%

Dental anxiety and salivary cortisol levels before urgent dental care

et al. 2009

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Dental anxiety is still prevalent, despite advances in treatment, and affects the utilization of health care services. The purpose of this cross-sectional study was to determine if patients with different degrees of dental anxiety and pain undergoing emergency dental care have different stress reactions as measured by salivary cortisol. Seventy three patients completed the modified dental anxiety scale (MDAS), and described any previous dental traumatic experience. Their socio-demographic characteristics were also recorded. They also rated pain intensity on a 100 mm visual analogue scale (VAS). A saliva sample was collected before the procedure, and analyzed by enzyme immunoassay. Thirty patients were dentally anxious and forty one complained of pain. In this sample, dental anxiety was not related to gender, age, educational level and family income; however, a previous traumatic event was related to dental anxiety. There was no association between salivary cortisol concentrations and gender or dental anxiety. Patients with pain showed higher cortisol levels. When gathering patient information, the dentist should note patients' negative dental experiences in order to provide more effective, less traumatic treatment. (J Oral Sci 51, 515-520, 2009)

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Section: Methodsmentioning

confidence: 99%

Dental anxiety and salivary cortisol levels before urgent dental care

et al. 2009

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“…In people, cortisol response to ACTH may be decreased by serotonin receptor agonists, progestagens, ketoconazole, and fluconazole and may be enhanced by propranolol . In veterinary medicine, the ability of glucocorticoids of any form, progestagens and ketoconazole to suppress cortisol secretion is known.…”

Section: Screening Testsmentioning

confidence: 99%

Diagnosis of Spontaneous Canine Hyperadrenocorticism: 2012 ACVIM Consensus Statement (Small Animal)

Behrend

Kooistra

Nelson

et al. 2013

Veterinary Internal Medicne

185

333

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Consensus Statements of the American College of Veterinary Internal Medicine (ACVIM) provide the veterinary community with up-to-date information on the pathophysiology, diagnosis, and treatment of clinically important animal diseases. The ACVIM Board of Regents oversees selection of relevant topics, identification of panel members with the expertise to draft the statements, and other aspects of assuring the integrity of the process. The statements are derived from evidence-based medicine whenever possible and the panel offers interpretive comments when such evidence is inadequate or contradictory. A draft is prepared by the panel, followed by solicitation of input by the ACVIM membership which may be incorporated into the statement. It is then submitted to the Journal of Veterinary Internal Medicine, where it is edited prior to publication. The authors are solely responsible for the content of the statements. This report offers a consensus opinion on the diagnosis of spontaneous canine hyperadrenocorticism. The possibility that a patient has hyperadrenocorticism is based on the history and physical examination. Endocrine tests should be performed only when clinical signs consistent with HAC are present. None of the biochemical screening or differentiating tests for hyperadrenocorticism are perfect. Imaging can also play a role. Awareness of hyperadrenocorticism has heightened over time. Thus, case presentation is more subtle. Due to the changes in manifestations as well as test technology the Panel believes that references ranges should be reestablished. The role of cortisol precursors and sex hormones in causing a syndrome of occult hyperadrenocorticism remains unclear. Diagnosis of Spontaneous

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“…Several medications with the capacity to influence cortisol levels via different pathways are documented [48,49]. Some of these medications may not only confound the association between cortisol and FSDs, but may also be used to change cortisol levels intentionally as an intervention.…”

Section: Do Alterations In Hpa Axis Activity Precede Fsd?mentioning

confidence: 99%

Dysfunction of stress responsive systems as a risk factor for functional somatic syndromes

Tak

Rosmalen

2010

Journal of Psychosomatic Research

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The etiology of functional somatic syndromes or disorders (FSDs) is generally considered to be a multifactorial interplay between psychological, biological, and social factors. One of the most investigated biological factors is stress responsive system dysfunction. Despite more than twenty years of research of the autonomic nervous system and the hypothalamic-pituitary-adrenal axis, however, it is yet unknown whether dysfunctions in these systems play a causal role in the etiology of FSDs and whether they are generic or FSD-specific. In this review, we will give an overview of available evidence on whether or not alterations in these stress responsive systems can be considered causal risk factors of FSDs. We conclude that although not necessary factors for FSDs in general, lowered cardiac vagal activity and hypocortisolism may be pivotal in the etiology and treatment strategy in subgroups of subjects with a FSD. Such subgroups need to be better identified.

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Drugs and HPA axis

Abstract: This paper outlines the interferences of the most widely used drugs with hypothalamo-pituitary-adrenal function and the related laboratory parameters, with the purpose of providing practical help to clinicians during testing for hypo- or hypercortisolemic states.

Cited by 28 publications

References 179 publications

Dental anxiety and salivary cortisol levels before urgent dental care

Dental anxiety and salivary cortisol levels before urgent dental care

Diagnosis of Spontaneous Canine Hyperadrenocorticism: 2012 ACVIM Consensus Statement (Small Animal)

Dysfunction of stress responsive systems as a risk factor for functional somatic syndromes

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