Drugs against chloroquine antimalarial itch

Asawalam, Beatrice; Osifo, Nosakhare G.; Haller, Louis

doi:10.1111/j.1468-3083.1993.tb00035.x

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…218 Dapsone (50 mg daily orally) reduced chloroquine-induced pruritus and limb-scratching activity significantly, whereas ketotifen, clemastine and prednisolone had no effect in a parallel-group trial. 222 Apart from the opioids and chloroquine, some drugs commonly reported to cause pruritus include angiotensin-converting enzyme inhibitors and statins, although the list of potential drugs is extensive. 205 Interestingly, epidural dexamethasone has been associated with causing generalized pruritus.…”

Section: Drug-induced Pruritusmentioning

confidence: 99%

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Millington¹,

Collins²,

Lovell³

et al. 2018

Br J Dermatol

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SummaryPruritus (or itch) is a common and distressing symptom of many skin diseases, systemic illnesses and psychological disorders. Itch is perhaps the commonest presenting symptom of skin disorders. In any two week period, 8 to 9% of the population suffer from significant pruritus. The focus of this guideline is not itchy rashes, but rather the situation where itch is present without rash. The guidelines also do not cover itch in children, in pregnancy, nor do they detail the science of the cause of itch. The study group consist mostly of dermatologists (skin specialists) from a number of hospitals in the U.K., but a number of other hospital doctors, a nurse and a general practitioner (GP) are also part of the team. There may be an underlying cause of pruritus, such as blood disorders, iron deficiency or excess, kidney problems, liver problems, cancer, infections, medications, behavioural factors, dry skin or any combination of these with old age. This can be significant in 20 to 30% of cases of itchy skin without rash. There remain a small number of individuals with itch and no apparent underlying cause or rash. It is always important to look for an underlying causative condition, as the most effective management of pruritus without rash depends on the treatment of any underlying disease. The management of itch appears to be very situation specific, even if the underlying cause cannot be treated. The management of true pruritus of unknown cause is different again.

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Section: Drug-induced Pruritusmentioning

confidence: 99%

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Millington¹,

Collins²,

Lovell³

et al. 2018

Br J Dermatol

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“…It was found that dapsone significantly reduced pruritus, but ketotifen and prednisolone did not significantly exceed the placebo responsiveness to vitamin B-complex tablets[18]. …”

Section: Approaches In the Management Of Pruritusmentioning

confidence: 99%

“…However, there could be variation in intensity among them. Chloroquine-induced pruritus has been reported in up to 50% of Black-skinned Africans[ 15 – 18 ]. This occurs 6-24 h after administration (oral, parenteral) and lasts for 4-5 days.…”

Section: Factors Influencing Pruritusmentioning

confidence: 99%

“…Dapsone or sulphapyridine (500 mg tablets, 6 hourly, orally daily for 5 days) was reported to have palliative effect against chloroquine-induced pruritus in adult patients of age between 16 and 32 years. It was found that dapsone significantly reduced pruritus, but ketotifen and prednisolone did not significantly exceed the placebo responsiveness to vitamin B-complex tablets[ 18 ].…”

Section: Approaches In the Management Of Pruritusmentioning

confidence: 99%

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Chloroquine-induced Pruritus

Aghahowa¹,

Obianwu²,

Isah³

et al. 2010

Indian J Pharm Sci

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Chloroquine-induced pruritus remains one of the most common side-effects in the use of chloroquine in the prophylaxis and treatment of uncomplicated malaria before the advent of artemisinin-based combination therapies. It has been reported to vary from a tolerable to intolerable intensity among susceptible individuals resulting in disruption of treatment and development of resistance to the drug thus leading to therapeutic failures as reported. This scourge is quite challenging due to the complex physiologic mechanism that has not been fully elucidated. Factors observed to be responsible in the induction of pruritus such as age, race, heredity, density of parasitaemia; impurities in formulations, plasmodial specie, dosage form and metabolites have been discussed in this review. Efforts to ameliorate this burden have necessitated the use of drugs of diverse pharmacological classes such as antihistamines, corticosteroids and multivitamins either alone or as a combination. This review is to look into the use of chloroquine retrospectively, and consider its re-introduction due to its safety. Efficacy can be attained if the pruritic effect is resolved.

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“…Dapsone (50 mg daily orally) reduced chloroquine‐induced pruritus and limb‐scratching activity significantly, whereas ketotifen, clemastine and prednisolone had no effect in a parallel‐group trial …”

Section: Investigation Of Generalized Pruritus Without Rash and Intermentioning

confidence: 99%

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

et al. 2018

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Drugs against chloroquine antimalarial itch

Cited by 7 publications

References 10 publications

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Chloroquine-induced Pruritus

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

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