Drugs affecting HbA1c levels

Abstract

Glycated hemoglobin (HbA1c) is an important indicator of glycemic control in diabetes mellitus, based on which important diagnostic and therapeutic decisions are routinely made. However, there are several situations in which the level of HbA1c may not faithfully reflect the glycemic control in a given patient. Important among these is the use of certain non-diabetic medications, which can affect the HbA1c levels in different ways. This review focuses on the non-diabetic medications which can inappropriately raise or lower the HbA1c levels, and the postulated mechanisms for the same.

Identifying persons at risk for developing type 2 diabetes in a concentrated population of high risk ethnicities in Canada using a risk assessment questionnaire and point-of-care capillary blood HbA1cmeasurement

“…It is possible, however, that some of the study participants who only provided Bio-Rad HbA 1c samples possessed some form of hemoglobinopathy. Additionally, there may be other factors such as prescription medication which may contribute to altered HbA 1c values [26] and it should be noted that this data was not captured by the risk questionnaire during this study. Adding questions regarding medication use would increase the complexity and duration of completing the questionnaire which would increase subject burden.…”

Falsely Decreased Hba1c in A Type 2 Diabetic Patient Treated with Dapsone

“…Measurement of HbA 1c was incorporated into clinical practice in the 1980s after studies demonstrated that it correlates with blood glucose measurements (3,4). Today, it is used as an indicator of glycemic control and as a diagnostic test for diabetes mellitus (4).…”

“…Today, it is used as an indicator of glycemic control and as a diagnostic test for diabetes mellitus (4). HbA 1c is formed by nonenzymatic condensation of glucose with the N-terminal valine residue of the β chains of hemoglobin (4,5).…”

“…Today, it is used as an indicator of glycemic control and as a diagnostic test for diabetes mellitus (4). HbA 1c is formed by nonenzymatic condensation of glucose with the N-terminal valine residue of the β chains of hemoglobin (4,5). Therefore, HbA 1c reflects the glucose level an erythrocyte has been exposed to during its lifespan and is a measure of glycemic control over the last 3 months, with the immediately preceding 30 days contributing 50% to the HbA 1c (4).…”

Frutosamina como principal parâmetro glicêmico do paciente diabético em hemodiálise

“…A HbS, por sua vez, é responsável por acarretar em valores falsamente aumentados desse parâmetro 39 . Níveis elevados de hemoglobina fetal, HbF, utilizada através do medicamento hidroxiureia para tratamento da anemia falciforme, por exemplo, pode resultar na diminuição dos níveis da HbA1c 40 . Ingestão crônica de aspirina e/ou altas doses de vitamina E e C, assim como outros antioxidantes, podem diminuir a concentração de HbA1c pois causam a inibição de glicação da hemoglobina 41 .…”