Drugs affecting dopamine neurons and yawning behavior

Mogilnicka, E; Klimek, Violetta

doi:10.1016/0091-3057(77)90224-6

Cited by 166 publications

(58 citation statements)

References 9 publications

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“…Apomorphine induces yawning as well (Holmgren & Urba- Holmgren, 1980;Mogilnicka & Short report 771 Klimek, 1977;Urba-Holmgren et al, 1982;Yamada & Furukawa, 1980). Apomorphineinduced yawning is antagonized by both typical (Protais et al, 1983) and atypical neuroleptics (Dubuc et al, 1982), but not by domperidone, a peripheral dopamine receptor blocker (Corsini et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

“…Variations in SBR (Karson, 1983;Karson et al, 1984) and yawning (Heusner, 1946) have been observed in various pathologies mainly related to dopaminergic system dysfunction: Parkinson's disease, progressive supranuclear palsy (PSP), Huntington disease, schizophrenia, Gilles de la Tourette syndrome. Apomorphine, a dopaminergic reference agonist, induces yawning (Holmgren & Urba-Holmgren, 1980;Mogilnicka & Klimek, 1977;Urba-Holmgren et al, 1982;Yamada & Furukawa, 1980) and increases SBR (Karson, 1983) …”

Section: Introductionmentioning

confidence: 99%

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Apomorphine‐induced blinking and yawning in healthy volunteers.

Blin¹,

Masson²,

Jp³

et al. 1990

Brit J Clinical Pharma

104

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Yawning and spontaneous blink rate (SBR) are two physiological reflexes which have been incompletely examined but one neurobiological step of these two behaviours seems, at least in part, dopamine‐dependent. The reference dopaminergic agonist, apomorphine hydrochloride (0.5, 1, and 2 micrograms kg‐1 s.c.), was compared with a placebo in a double‐blind latin‐square design, and was shown to induce yawning and increase SBR in a population of eight healthy volunteers. These two behavioral effects were not dose‐related. The individual SBR differences were correlated with the individual number of yawns for all the four treatments at the 10‐30 min interval. Thus, parallel yawning and SBR behaviour suggests a similar pharmacological mechanism. Apomorphine‐ induced yawning and blinking may be therefore of use in the evaluation of central dopaminergic pathways in man.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Apomorphine‐induced blinking and yawning in healthy volunteers.

Blin¹,

Masson²,

Jp³

et al. 1990

Brit J Clinical Pharma

104

View full text Add to dashboard Cite

show abstract

“…Apomorphine. Apomorphine, a dopamine receptor agonist that stimulates both dopamine D 1 -and D 2 -like receptors, has been shown to induce penile erection in rats (Mogilnicka and Klimek, 1977;Benassi-Benelli et al, 1979) as well as in healthy men (Lal et al, 1984) and in men with ED (Lal et al, 1987(Lal et al, , 1989. L-DOPA may also stimulate erection in patients with Parkinson's disease (see, e.g., Vogel and Schiffter, 1983).…”

Section: Drugs For Nonintracavernosal Administrationmentioning

confidence: 99%

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

2011

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“…Yawning behavior in rats has been a long studied phenomenon, and is known to be regulated by a variety of neurotransmitter systems including cholinergic (Urba- Holmgren et al 1977;Yamada & Furkawa 1980), serotonergic (Stancampiano et al 1994), and dopaminergic (Mogilnicka & Klimek 1977;Holmgren & Urba-Holmgren 1980) systems associated with the paraventricular nucleus of the hypothalamus (Argiolas & Melis 1998). Recently, a specific role for the D3 receptor in the induction of yawning behavior has also been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists

et al. 2007

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Rationale-Identification of behaviors specifically mediated by the dopamine D2 and D3 receptors would allow for the determination of in vivo receptor selectivity and aide the development of novel therapeutics for dopamine-related diseases.Objectives-These studies were aimed at evaluating the specific receptors involved in the mediation of D2/D3 agonist-induced yawning and hypothermia.Correspondence to: James H. Woods. NIH Public AccessAuthor Manuscript Psychopharmacology (Berl) Methods-The relative potencies of a series of D2-like agonists to produce yawning and hypothermia were determined. The ability of D3-and D2-selective antagonists to inhibit the induction of yawning and hypothermia were assessed, and a series of D2/D3 antagonists were characterized with respect to their ability to alter yawning induced by a low and high dose of PD-128,907 as well as sumanirole-induced hypothermia.Results-D3-preferring agonists induced yawning at lower doses than those required to induce hypothermia, and the D2-preferring agonist, sumanirole, induced hypothermia at lower doses than were necessary to induce yawning. The rank order of D3 selectivity was pramipexole > PD-128,907 = 7-OH-DPAT = quinpirole = quinelorane > apomorphine = U91356A. Sumanirole had only D2 agonist effects. PG01037, SB-277011A and U99194 were all D3-selective antagonists, whereas haloperidol and L-741,626 were D2-selective antagonists and nafadotride's profile of action was more similar to the D2 antagonists than to the D3 antagonists.Conclusions-D3 and D2 receptors have specific roles in the mediation of yawning and hypothermia, respectively, and the analysis of these effects allow inferences to be made regarding the selectivity of D2/D3 agonists and antagonists with respect to their actions at D2 and D3 receptors.

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Drugs affecting dopamine neurons and yawning behavior

Cited by 166 publications

References 9 publications

Apomorphine‐induced blinking and yawning in healthy volunteers.

Apomorphine‐induced blinking and yawning in healthy volunteers.

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists

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