Drugs acting on the central nervous system. Syntheses of substituted quinazolinones and quinazolines and triazepino- and triazocinoquinazolinones

Functionalization of Quinazolin‐4‐Ones Part 2#: Reactivity of 2‐Amino‐3, 4, 5, or 6‐Nitrobenzoic Acids with Triphenylphosphine Thiocyanate, Alkyl Isothiocyanates, and Further Derivatization Reactions

“…It is known that 2‐amino quinazolin‐4‐ones can be synthesized by treating 2‐alkylthio quinazolin‐4‐ones with amines . From our previous investigations, it was shown that substituents on the 7 position (NO 2 , NH 2 , NH(C = O)CH 3 ) did not affect the susceptibility of the methylthio group toward morpholine .…”

“…Quinazolines form a large family of compounds that are well recognized for their ability to show a broad range of biological activities, which are influenced significantly by the type of substituents and where they are placed around the quinazoline structure . Observed biological activities include, but are not limited to, CNS depressant , anti‐inflammatory , diuretic , antihypertensive , analgesic , anticancer , antihypoxic , hypoglycemic , and antimicrobial activities. The ability to synthesize and functionalize quinazolines is therefore of great importance, and the methods employed will reflect the structure of the desired quinazolines.…”

Four Partners, Three‐Step, One‐Pot Reaction for a Library of New 2‐Alkyl(dialkyl)aminoquinazolin‐4(3H)‐ones

“…The natural quinazolinones and their synthetic analogs possess a variety of biological activities including antimalarial , anticonvulsant , antibacterial , antifungal , antidiabetic , anticancer , antihypertensive , antiallergy , antihyperglycemic , and plant protecting agents . Also, some quinazolinone derivatives displayed antimycobacterial activities , and others were reported as selective phosphodiesterase 5 inhibitors , vasodilator , antitubercular , antihyperlipidemic , antidiuretic , protein tyrosine kinase inhibitor , cholecystokinin inhibitor , anti‐inflammatory, analgesic agents, and COX‐II inhibitors .…”

Synthesis, Tautomeric States and Crystal Structure of (Z)-Ethyl 2-Cyano-2-(3H-Quinazoline-4-ylidene) Acetate and (Z)-Ethyl 2-Cyano-2-(2-Methyl-3H-Quinazoline-4-ylidene) Acetate

“…Among them are found a series of highly effective agricultural compounds, such as fungicides, bactericides, defoliants and plant growth stimulants [ 1 , 2 , 3 ]. Compounds of this class also are used as medicinal drugs with various pharmacological activities [ 4 , 5 ]. It is known that pyrimidine system derivatives that contain activated methylene group residues can exist in different tautomeric forms [ 6 ].…”