Drug utilization study of antihypertensive drugs in hypertensive diabetic patients in a tertiary care hospital

Raikar, Shrinivas; Patil, Shivaraj B.; Raikar, Dayanand; Mantale, Nagendra

doi:10.18203/2319-2003.ijbcp20150382

Cited by 2 publications

(4 citation statements)

References 13 publications

(13 reference statements)

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“…As per WHO the average number of drugs prescribed should be 2-3 6 . This finding was also supported by a study by Raikar, Shrinivas R. et al 7 Average number of antihypertensive drugs per prescription in our study was 1.34 which were in favor of findings of other studies. According to Rimoy et al, 8 average number of antihypertensives was 1.6 whereas Ramada S. et al, 9 reported a similar number of average 1.4 antihypertensive drugs.…”

Section: Discussion: Assessment Of Drug Utilization Of Antihypertensisupporting

confidence: 91%

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Introduction: Hypertension, is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications. Given the prevalence and impact of the disease on health care a drug utilization study becomes essential to determine the current drug utilization pattern. Materials and Methods: 127 patients of hypertension coming to the OPD of medicine of King George's Medical University were enrolled in the study after screening and giving consent. The data from the prescription of the drugs were recorded in pre-specified case record forms and analyzed for drug utilization parameters. Results: The average number of drugs encountered per prescription was 4. Whereas prescriptions with the generic name were 38% and drugs from an essential drug list were found to be 74%. The most commonly prescribed antihypertensive group was calcium channel blocker (25.1%) in monotherapy followed by angiotensin receptor blocker (21.2%). In combination therapy, the most commonly prescribed combination was found to be calcium channel blocker + angiotensin receptor blocker (17.3%). The drugs were prescribed in doses either equal to or less than the WHO DDD prescribed except telmisartan which was prescribed in a higher dose. A major finding was decreased in the angiotensin-converting enzyme inhibitor prescription and rise in angiotensin receptor blocker. Conclusion: Results of our study showed a lower rate of polypharmacy reporting and adherence to a national essential list of medications. The drugs being prescribed also fell well within the WHO recommended Daily Defined Dose (DDD). INTRODUCTION: Hypertension is a global public health issue. It is a significant contributor to rising morbidity and mortality because of its associations with cardiovascular, renal and cerebrovascular complications.

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Section: Discussion: Assessment Of Drug Utilization Of Antihypertensisupporting

confidence: 91%

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“…Angiotensin receptor blockers (ARB) + diuretics + βblockers (44.44%) are mostly observed classes as threedrug therapy in hypertension alone grouped patients. Similar results were found in the study done by Etuk E et al 26 and Raikar SR et al 27 The combination of ACEI/ARB + BB + diuretic is justified since diuretics produce potassium loss, while drugs interfering with RAS conserve potassium.…”

Section: Discussionsupporting

confidence: 85%

“…This leads to polypharmacy, increasing cost and chances of ADRs. Similar results were obtained by Karunakar Kota et al, 19 Mirza AtifBeg et al, 30 Raikar SR et al, 27 Okonta JM et al, 28 Shende et al, 32 Sweileh WM et al 36 and Sandozi T et al 37 The reasons for polypharmacy may be due to coexisting diseases, nonspecific complaints by the patients and low average consultation time given by practitioners.…”

Section: Discussionsupporting

confidence: 61%

“…As many as 68.30% of antihypertensive medicines were prescribed by their generic names. This is on higher side as compared to Jayanth et al, 31 Mirza Atif Beg et al 30 and Raikar SR et al 27 Difference may be attributed to the present study being done in a government setup and availability of generic drugs in stores. Prescriptions with generic drugs should be promoted.…”

Section: Discussioncontrasting

confidence: 57%

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Drug Utilisation Study in the Treatment of Hypertension in a Tertiary Care Hospital

Deshmukh¹,

Tamboli²,

Ghadlinge³

et al. 2017

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BACKGROUND Hypertension, a common clinical problem is considered as an 'iceberg disease' because its unknown morbidity far exceeds the known morbidity. In terms of attributable deaths, it is one of the leading behavioural and physiological risk factors amounting to 13% of global deaths. Drug selection is based on efficacy in lowering BP (blood pressure) and in reducing Cardiovascular (CV) endpoints like stroke, myocardial infarction and heart failure. This study was carried out to evaluate the pattern, extent, rationality and frequency of the use of antihypertensive drugs in the treatment of hypertension. The aim of the study is to analyse drug utilisation in the treatment of hypertension in a tertiary care hospital. MATERIALS AND METHODS This study was conducted during January 2014 to December 2015 in Medicine OPD (Outpatient Department) in a tertiary care hospital. The sample size was selected as per the WHO recommendations on conducting Drug Utilisation Studies (DUS). Statistical Analysis-The collected data was numerically coded and entered in Microsoft Excel 2007 and analysed by SPSS version 16. Settings and Design-Prospective, cross-sectional, observational study. RESULTS Out of 612 patients, 262 (42.81%) were in the age group of 60 and above. Considering gender distribution, 328 (53.59%) were males and 284 (46.41%) were females. Of these, 274 (44.78%) were prescribed monotherapy, 256 (41.83%) were prescribed two-drug therapy, 72 (11.76%) were prescribed three-drug therapy and 10 (1.63%) were prescribed four-drug therapy. Among 274 (44.78%) patients prescribed with monotherapy, 112 (40.87%) were prescribed with CCB (calcium channel blocker), 76 (27.73%) were given BB (B-blocker), 45 (16.42%) were prescribed ACEI (angiotensin converting enzyme inhibitor), 35 (12.77%) were prescribed with ARB (angiotensin receptor blocker) and 6 (2.18%) were prescribed with Diuretics (D). Of the total antihypertensive drugs prescribed, 68.30% were prescribed by generic name, while 25.98% were prescribed as FDCs (fixed drug combination) and 39.05% of antihypertensive drugs were from NLEM (national list of essential medicine). Average number of drugs prescribed per encounter in our study was 2.42, while number of antihypertensive drugs per encounter were 1.34. CONCLUSION The findings of our study suggest that majority of prescriptions had generic names of the drugs. Improving practitioners' knowledge and attitude in rational prescribing can prove to be a cornerstone in achieving rational use of antihypertensive drugs.

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Drug utilization study of antihypertensive drugs in hypertensive diabetic patients in a tertiary care hospital

Cited by 2 publications

References 13 publications

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Drug Utilisation Study in the Treatment of Hypertension in a Tertiary Care Hospital

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