Drug utilization review of anticancer drugs in cancer outpatient department of the Government Medical College, Aurangabad

Kulkarni, Madhuri; Hussaini, Samra A.; Padwal, Sudhir L.; Khandelwal, Prakash Narayan; Doifode, S. M.; More, Pallavi

doi:10.5455/2319-2003.ijbcp20141030

Cited by 8 publications

(8 citation statements)

References 1 publication

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“…Present study shows that the incidence of carcinoma is high in females as compared to that in males (62 females vs. 38 males), Kulkarni et al, also found that the incidence of carcinoma in females is more than that of males and has written about it in his research article. 12 As the risk of cancer increases with age, a similar pattern was seen in our study. A major 58% of patients were above the age of 50 years.…”

Section: Discussionsupporting

confidence: 89%

Prescribing pattern of anticancer drugs in the medical oncology department of a tertiary care teaching hospital

Beedimani¹,

Zaman

Potturi

et al. 2019

Int J Basic Clin Pharmacol

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Background: To study drug utilization of anticancer drugs in the oncology inpatient department (IPD) of Kamineni Hospitals, L.B. Nagar, Hyderabad, India.Methods: One hundred prescription records were screened and analysed as per the study parameters from the oncology IPD of Kamineni Hospitals, Hyderabad. Commonly used anticancer drugs were recorded; furthermore, different types of carcinomas were noted.Results: Age group of patients was in between 04 and 80 years, 62 were females and 38 were male patients. The most common type of carcinoma was carcinoma of the breast (28%). Cisplatin was the most commonly used anticancer drug (29%). Adjuvant drugs were used in 98% of the patients.Conclusions: Incidence of cancer is more in females than males. Adjuvant and cytoprotective drugs used may have had a bearing on the relatively lower incidence of adverse effects.

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Section: Discussionsupporting

confidence: 89%

Prescribing pattern of anticancer drugs in the medical oncology department of a tertiary care teaching hospital

Beedimani¹,

Zaman

Potturi

et al. 2019

Int J Basic Clin Pharmacol

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“…In our study, Paclitaxel was commonly prescribed chemotherapeutic agent (34%) followed closely by 5-fluorouracil (32%). This was quite similar to the results reported by Kulkarni et al, showing carboplatin followed by paclitaxel [13]. Among the different classes of cytotoxic drugs observed, alkylating agents was the most prescribed class followed by antimetabolites, antitumor antibiotics, and plant alkaloids.…”

Section: Discussionsupporting

confidence: 81%

“…On analyzing the distribution pattern of cancer patients according to gender, the data represented that cancer was more prevalent in females (54%) than males (46%) in the age between 1-80 y. This data was found to be consistent with the observation of female (52.14%) and male (47.85%) as reported by Kulkarni et al, [13]. The greater prevalence of cancer in females can be due to the involvement of their reproductive system which is more susceptible such as cervix, ovary, and breast and occupies the major portion of all other forms of cancer.…”

Section: Discussionsupporting

confidence: 80%

To Study the Therapeutic Management, Drug Related Problems and Concomitant Use of Drugsin Patients With Cancer

Pramila

Abraham

Pawar

et al. 2017

Int J Pharm Pharm Sci

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Objective: To study the prescribing patterns of chemotherapeutic drugs, concomitant drugs and to determine the drug-related problems in cancer patients. Methods:A prospective and retrospective observational study was conducted over a period of 6 mo in a tertiary care teaching hospital, Pune after ethical approval and informed consent. Patients were then interviewed for patient information like demographics, treatment, and associated drug related problems using specially designed proforma and then required data was introduced in Microsoft excel spreadsheets. Results:Out of 60 patients 50 were enrolled in this study during which 9 different sites of cancer were examined. The maximum number of patients with cancer resides in the age group of 51-60 y (32%) and more common in females in 27 (54%). The most prevalent risk factor and co-morbidity encountered were tobacco chewing 13 (26%) and hypertension 8 (16%), respectively. On the further evaluation of data, the findings suggested that the majority of patients were prescribed with an alkylating group of anti-neoplastic agents, paclitaxel+platinum-based compound regimen, and the drug paclitaxel. On screening, 167 drug interactions were observed, of these most of the interactions were in the moderate category. The most common organ system affected was gastrointestinal system 135 (30.80%) whereas the prevalent toxicity was hyperuricemia. Polypharmacy was not observed, whereas antacid (ranitidine) was frequently prescribed during hospitalisation and discharge. Conclusion:This study has highlighted certain facts and drawbacks in medication-related care which can be addressed by conducting future studies in cancer care in order to provide patient-specific outcomes.

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“…Cytotoxic drugs have a narrow therapeutic index (TI) and the dosage needed to achieve the therapeutic effect would also cause severe toxic effects. 16 In present study, most commonly prescribed anti-cancer drug is cisplatin followed by 5-flurouracil and this is inconsistent with the findings of Mugada et al and Kulkarni et al 9,14 Cisplatin's major side effect is nephrotoxicity. Here cisplatin was given as rapid infusions along with nephroprotective agents such as mannitol and magnesium sulphate (MgSO4).…”

Section: Discussioncontrasting

confidence: 69%

Assessment of drug utilization pattern in patients undergoing chemotherapy for various types of metastatic cancers in a tertiary care government hospital

Vijayalakshmi

Bendi

Usharani

et al. 2020

Int J Basic Clin Pharmacol

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Background: Cancer is one among main causes of morbidity and mortality in developing and developed countries. The World Cancer Report 2014 of World Health Organization’s (WHO’s) International Agency for Research on Cancer (IARC), states that in 2012 the global incidence of cancer increased to a 14 million new cases, the figure expected to rise to an annual 19.3 million by 2025. The prescription pattern of anticancer drugs has evolved considerably in recent years because of better understanding of underlying pathophysiology of carcinomas as well as introduction of newer drugs. Methods: It was a hospital-based prospective, cross-sectional study conducted in Department of Oncology, GGH, Kakinada for a period of twelve months from February 2017 to January 2018. A total of 100 patients were enrolled using convenience sampling technique. Patient demographics like age, gender, educational level, employment status, marital status, smoking category, alcohol consumption, stage of cancer was collected. Drug utilization pattern was obtained from inpatient case reports, prescriptions and medication charts used during a chemotherapy cycle.Results: Among all anticancer drugs, cisplatin and 5-flurouracil were most commonly prescribed followed by Adriamycin. The most commonly used adjuvant drugs were B-complex, diclofenac, granisetron, ranitidine, dexamethasone. Antibiotic use was found to be very limited.Conclusions: Various anticancer drug prescription patterns are being used for treatment of patient with metastatic cancers. In this study, cisplatin and 5-flurouracil were commonly used. Injudicious antibiotic prescribing was not observed.

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Drug utilization review of anticancer drugs in cancer outpatient department of the Government Medical College, Aurangabad

Cited by 8 publications

References 1 publication

Prescribing pattern of anticancer drugs in the medical oncology department of a tertiary care teaching hospital

Prescribing pattern of anticancer drugs in the medical oncology department of a tertiary care teaching hospital

To Study the Therapeutic Management, Drug Related Problems and Concomitant Use of Drugsin Patients With Cancer

Assessment of drug utilization pattern in patients undergoing chemotherapy for various types of metastatic cancers in a tertiary care government hospital

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