Drug utilization pattern of antihypertensive drugs in chronic kidney disease patients in a tertiary care hospital

Abstract

Objectives: To analyze utilization of antihypertensive drugs in chronic kidney disease patients in a tertiary care hospital. Materials and Methods: A descriptive prospective study was conducted in the dialysis unit of Bapuji hospital, Davangere during 6 month period in 2013 with stage III to V of chronic kidney disease patients. Data from case record of all patients was collected, relevant information entered in a preformed proforma and analyzed. Results: Total of 120 case records were analyzed, 30 % patients were 51-60 years, 27 % patients were 61-70 years and male to female ratio of 74: 26. Out of 120 patients, 54 patients (45 %) were diabetic with hypertension and 66 patients (55 %) were nondiabetic with hypertension. In diabetic patients with hypertension, 66.6 % were two drugs combinations, cilnidipine and torsemide (52%), amlodipine and furosemide (28%) metoprolol and cilnidipine (11%). 30% with three drug combinations. Nondiabetic patients with hypertension, 55 % had three drugs combinations, Metroprolol, furosemide, prazosin (45%), Cilnidipine, torsemide, prazosin (33 %) and 45 % two drugs combinations, amlodipine, furosemide (46%) and metoprolol, torsemide (33%) were commonly used. Conclusion: Combination of diuretic and calcium channel blockers (80 %) was commonly used in hypertensive patients with diabetic. Beta blocker because of its known adverse effects in diabetic patients (hypoglycemic unawareness) is getting less commonly used than in nondiabetic. Use of antihypertensive drugs such as selective beta blocker, alpha-blocker, Calcium channel blocker combination (45 %) more commonly used in nondiabetic with hypertension.