Drug utilization pattern in acute coronary syndrome at tertiary care hospital: a prospective cross-sectional observational study

Choudhary, Praveen; Agrawal, Jitendra M.; Malhotra, Supriya D.; Varsha, J

doi:10.18203/2319-2003.ijbcp20160771

Cited by 7 publications

(11 citation statements)

References 5 publications

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“…7,12,13 Although, this particular finding was contradictory to the findings cited by Yusuf et al, Rajanandha et al, Choudhary et al, Vamadevan et al, mentioning underuse of these 4 evidenced based drugs used for secondary prophylaxis in low income countries. 3,8,10,17 Anti-anginal drugs were prescribed to 70% of patients which was comparable to the reports presented by Dawalji et al, Sandozi et al, Thaker et al, in the similar studies. 13,15,18 The use of lipid lowering agent was found in 89% of patients which was again similar to the findings stated by Dawalji et al, Choudhary et al, Thaker et al, reflecting the rational use of these drugs for the purpose of secondary prophylaxis in CAD.…”

Section: Discussionsupporting

confidence: 80%

“…13,15,18 The use of lipid lowering agent was found in 89% of patients which was again similar to the findings stated by Dawalji et al, Choudhary et al, Thaker et al, reflecting the rational use of these drugs for the purpose of secondary prophylaxis in CAD. 13,17,18 In present study, authors also found 51% of patients were prescribed aspirin and clopidogrel along with a proton pump inhibitor. This finding perhaps is contradictory to the textual evidence stating the reduction in the therapeutic benefit of clopidogrel when administered with a proton pump inhibitor.…”

Section: Discussionsupporting

confidence: 63%

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Evaluation of prescribing pattern of drugs use in patients of coronary artery disease at a tertiary care hospital

Belhekar

Patel

Singh

et al. 2018

Int J Basic Clin Pharmacol

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Background: Coronary artery disease (CAD) is a major cause responsible for mortality more in younger age group than in elderly. Studies have reported underuse of four evidence based medicines namely aspirin, β-blockers, angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB), and statins in patients with CAD, particularly in developing countries. Therefore, this study was planned to analyse the prescriptions of patients with CAD to determine the appropriateness of the prescriptions.Methods: After obtaining the Institutional ethics committee permission, a cross sectional observational study was conducted at a tertiary care hospital. Total 150 patients were enrolled from the outpatient department, wards and intensive care unit of medicine department. Total 150 patients’ prescriptions presenting with varied category of CAD were screened and analysed.Results: The most common categories of CAD encountered was ST segment elevated myocardial infarction (N=50, 33%) followed by chronic stable angina (N=29, 20%). Among the drugs prescribed, antiplatelet drugs were prescribed to 135 (90%), hypolipidemics to 134 (89%), nitrates to 114 (76%), beta blockers to 97 (65%), ACE inhibitors to 94 (64%), anticoagulants to 60 (40%) and miscellaneous drugs to 52 (35%), patients. Of 68 (45%) patients with type 2 diabetes mellitus, 15 (22%) were prescribed only metoprolol and others were given ACE-I or ARBs.Conclusions: Among four evidence based drugs, use of 3 drugs, antiplatelets, beta blockers and hypolipidemics was apparent in 90% of prescriptions. Use of ACE inhibitors and ARBs was observed in type 2 diabetic patients with CAD, reflecting rational prescribing behavior of clinicians.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 63%

Evaluation of prescribing pattern of drugs use in patients of coronary artery disease at a tertiary care hospital

Belhekar

Patel

Singh

et al. 2018

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

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“…8 This shows that acute coronary syndrome is more in this age group. In our study males (93) were more common than the females (32), which was comparable to other studies which say that cardiovascular emergencies were more common in males than the females.…”

Section: Discussionmentioning

confidence: 84%

“…8,9 The association of physicians of India recommends that all patients with myocardial infarction should receive dual antiplatelet therapy. 8 It was told in another study that Aspirin along with Clopidogrel may offer benefits over either drug used alone in Ischemic heart disease associated with Hypertension and Diabetes mellitus. 4 In our study Atorvastatin was the preferred Hypolipidemic drug given to all patients (100%) as similar to another study.…”

Section: Discussionmentioning

confidence: 99%

A study of drug utilization trends in acute coronary syndrome in intensive cardiac care unit at a tertiary care hospital, Mysore

Lakshmi

Gowda

Sadananda

2017

Int J Basic Clin Pharmacol

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Background: Acute Coronary Syndrome (ACS) is an emergency condition where usage of many drugs during its management in ICCU is common. This could be a potential cause for Polypharmacy, Potential Drug-Drug Interactions and increased Cost Burden on patients. The objective of the study was WHO criteria for prescription like, 1) Average number of drugs per prescription, 2) Percentage of drugs prescribed by Generic name, 3) Percentage of drugs with Injections prescribed, 4) Percentage of prescriptions with Antibiotics and 5) Percentage of drugs prescribed from the WHO Essential Drugs List.Methods: After obtaining approval from Institutional Ethics Committee, an observational study was carried out among 125 patients in a tertiary care hospital, Mysore. Patients diagnosed with ACS admitted in Intensive Cardiac Care Unit (ICCU) for initial 48 hrs were included in the study. The prescriptions were analyzed for WHO criteria for prescription. The results were analyzed using Descriptive Statistics and T- test.Results: In our present study the most common diagnoses were found to be ACS- Anterior wall myocardial infarction (36.8%) and ACS-Inferior wall myocardial infarction (32.8%). Hypertension (35.2%) and Type 2 diabetes mellitus (29.6%) were the frequently associated co-morbid conditions. Antiplatelet drugs (100%) and Hypolipidemic drugs (100%) were the most commonly prescribed, followed by Anti coagulants (94.4%). The average number of drugs per prescription was 9.09±2.17. Percentage of drugs prescribed by generic names was 37.29%. The percentage of drugs prescribed from essential drug list was 50.84%.Conclusions: The present study provides valuable insight about the overall pattern of drugs used in Acute Coronary syndrome. Physician should be encouraged to prescribe drugs with generic name.

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“…98.3% drugs were prescribed by brand names and which was higher than results reported by Christian et al (19.5%, 80.5% -generic names and brand names respectively) and Choudhary et al (16.88% drugs prescribed by generic names and 83.12% drugs by brand names). 19,21 Low instances of prescription of drug by generic names should be addressed appropriately as prescribing drugs by brand names not only inflates the cost but also evokes an adverse drug response due to confusing drug nomenclature. 22 Use of drugs from the National List of Essential Medicines was 92.79% which was higher than the findings of Christian et al (75.7%) and Al Junid et al (28%).…”

Section: (2455%)mentioning

confidence: 99%

Study of utilisation trends of drugs in patients admitted with cardiovascular diseases at a tertiary care hospital in Goa

Kerkar

Bhandare

2017

Int J Sci Rep

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Background: CVDs have emerged as a leading cause of mortality and morbidity in the world as well as in India. Drug usage is life saving and at times many drugs may be needed. Drug utilization studies aid to find the appropriateness of treatment, identify shortcomings if any, and provide a feedback to the healthcare providers to improve their management with drugs. So such types of studies are of vital importance in every hospital.Methods: This was a prospective, observational study of 180 patients with CVDs admitted in medicine and cardiology wards of a tertiary care hospital, conducted through case records and patients’ interviews. Data was represented as mean±SD, number and frequency. Results: Incidence of cardiovascular diseases was more in males (56.67%) than the females (43.33%). Average number of drugs prescribed per patient was 9.16 and that of cardiovascular drugs was 5.08 ± 2.15. Antiplatelets (88.88%) were the most commonly prescribed cardiovascular drugs followed by hypolipidemics (82.22%). About 15.06% of injectables and 1.2% of fixed dose combinations (FDCs) were prescribed. Drugs prescribed by generic names were 1.6% and those from the National List of Essential Medicines were 92.79%.Conclusions: The results of this study suggested: polypharmacy, overuse of injections and low prescribing habits from essential drug list. Though antiplatelet, hypolipidemic use was higher, these are an essential part of treatment of certain CVDs.

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Drug utilization pattern in acute coronary syndrome at tertiary care hospital: a prospective cross-sectional observational study

Cited by 7 publications

References 5 publications

Evaluation of prescribing pattern of drugs use in patients of coronary artery disease at a tertiary care hospital

Evaluation of prescribing pattern of drugs use in patients of coronary artery disease at a tertiary care hospital

A study of drug utilization trends in acute coronary syndrome in intensive cardiac care unit at a tertiary care hospital, Mysore

Study of utilisation trends of drugs in patients admitted with cardiovascular diseases at a tertiary care hospital in Goa

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