Drug Utilization Evaluation of Antibiotics in General Medicine Department of a Tertiary Care Hospital

Gowthami, Buduru; Spurthi, T

doi:10.1016/j.jval.2016.08.645

Cited by 13 publications

(21 citation statements)

References 2 publications

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“…Similar findings were observed in many studies 12,13,14 . Amongst cephalosporins, third generation is the most commonly prescribed one.…”

Section: Discussionsupporting

confidence: 92%

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2018

IJPSR

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Objective: Antimicrobials have become one of the most misused therapeutic agents resulting in resistance. Present study was carried out to evaluate the antimicrobial drug utilization pattern. Method: A retrospective, observational record based study was done in hospitalized patients from medicine and surgery department of tertiary care hospital of central India over a period of one year. Result: Among 385 patients, 53.25% were females and 26.75% were in 41 -50 years age group. Amongst 775 antimicrobials prescribed, 75% were injectables. Average number of antimicrobials per prescription was 2.01 ± 0.6. Use of antimicrobial monotherapy (39.74%) was common and 25.71% had more than two antimicrobials. About 33.16% drugs were prescribed by generic names and FDCs were prescribed in 37.14%. Culture and sensitivity tests were done in 35.6% cases. Cephalosporins (65.19%) were the most preferred antimicrobials followed by penicillins, aminoglycosides and antiamoebics. Ceftriaxone, amikacin and metronidazole were the most commonly prescribed antimicrobials. Prescribed daily dose (PDD) was greater than defined daily dose (DDD) for ceftriaxone, amikacin, amoxicillin, metronidazole and levofloxacin indicating their wide usage. Conclusion: Antimicrobials' prescribing in our hospital is empirical; there is a need for strict antibiotic prescription policy. Generic drug prescribing should be encouraged. Such type of studies should be carried out regularly to evaluate the changes in the pattern and its rationality.

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“…Similar findings were observed in many studies 12,13,14 . Amongst cephalosporins, third generation is the most commonly prescribed one.…”

Section: Discussionsupporting

confidence: 92%

Untitled

2018

IJPSR

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“…Pallavi et al, Randad et al, and Gowthami et al found the same result in their study [5][6][7]. Some studies found exactly opposite results [8].…”

Section: Discussionsupporting

confidence: 52%

“…Betalactams are commonly used AMA and use abundantly in practice. There are many studies who found same result [4,7,[9][10][11][12][13].Beta-lactams are well established AMAs regarding their efficacy and safety that may lead to its widespread use. Pallavi et al found broad-spectrum antibiotic was most common in their study [5].…”

Section: Discussionmentioning

confidence: 87%

A Prospective Study on Antimicrobial Utilization Pattern in Outpatient Department at Tertiary Care Hospital, Pune, India.

Deshmukh

Agarwal

Hiran

et al. 2018

Asian J Pharm Clin Res

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Objective: The objective of the study was to evaluate antimicrobial prescription pattern in outpatient departments.Method: This was a prospective, cross-sectional and observational study over 12 weeks total 400 prescriptions of either gender and age; containing antimicrobial agents (AMAs) were analyzed for demographic data and the WHO prescribing indicators.Results: Most of prescription were given to men (n=262). The most common group of AMA used was Cephalosporins (n=141, 35.25%); of which Ceftriaxone was most commonly prescribed (n=73, 18.25%). 10 AMAs were from the WHO essential medicine list AMAs. Men outnumbered women in prescribing antibiotics (n=262 vs. 138). Most of AMAs receivers were between 26 and 35 years (n=128, 32%). Amoxicillin+Clavulanic acid fixeddose combination was most common (n=84, 21%). Most of the prescriptions were containing four drugs per prescriptions (n=130, 32.5%). Only 10% of the prescription was given by generic name and rest 90% were given by brand name. Oral dosage form of AMAs was predominant (n=340, 85%). Vitamins and supplement were most common comedication received by patients. Conclusion:Antibiotic use was found to be reasonable and rational in most of the cases. However, still, prescribers should improve prescribing practices and make it more rational.

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“…The reasons that could be ascribed to this is the change in the epidemiological trend of violently increased prevalence of non-communicable diseases such as diabetes, hypertension, dyslipidemia, and coronary artery disease which are often synchronized contributing to the require for treating numerous disease entities in the same patient concurrently. 7 Concomitance of such cardio metabolic circumstances in a solitary patient further entails the mandatory for prescribing more than a single drug for a known clinical indication which is frequently opposed to treatment in the face of several diseases presenting simultaneously. Present study also stands witness to this fact as a high percentage of participants (68.6%) had the analysis of non-communicable disease with diabetes ranking highest with 34.4%.…”

Section: Discussionmentioning

confidence: 99%

Prescription pattern at outpatient department in a tertiary care hospital of Gujarat: a cross-sectional study

Gohil¹

2019

Int J Basic Clin Pharmacol

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Background: Evaluation of drug prescription prototype is a significant feature of patient care, which also provides as an estimate of the quality of care provided. Thus, the current study was carried out to analyze the prescriptions of patients attending outpatient department (OPD) of a tertiary care teaching hospital.Methods: Present cross-sectional study was performed in the OPD of our tertiary care teaching hospital. The study was carrying out for duration of two years. Data was obtained from 850 prescriptions. Data was analysed as per WHO prescribing indicators.Results: Total 1700 prescriptions were analysed, that includes 55.8% males and 40.1% females. The highest numbers of prescriptions were from the age group of 18-40 (53.6%) years of age. Average number of drugs in the current study was found to be (2.1). Percentage of come across with an antibiotic prescribed was 17.12%. Percentage of come across with an injection prescribed was 11.81%.Conclusions: There is necessitate of recuperating the prescribing pattern by maintaining the number of medicines as little as possible, prescribing medicines by generic names, using medicines properly after selecting and deliberately keeping the charge of treatment low.

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Drug Utilization Evaluation of Antibiotics in General Medicine Department of a Tertiary Care Hospital

Cited by 13 publications

References 2 publications

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A Prospective Study on Antimicrobial Utilization Pattern in Outpatient Department at Tertiary Care Hospital, Pune, India.

Prescription pattern at outpatient department in a tertiary care hospital of Gujarat: a cross-sectional study

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