Drug Utilisation Patterns of Alternatives to Ranitidine-Containing Medicines in Patients Treated with Ranitidine: A Network Analysis of Data from Six European National Databases
Johnmary T. Arinze,
Maria A. J. de Ridder,
Dina Vojinovic
et al.
Abstract:Introduction
Ranitidine, a histamine H
2
-receptor antagonist (H
2
RA), is indicated in the management of gastric acid-related disorders. In 2020, the European Medicines Agency (EMA) recommended suspension of all ranitidine-containing medicines in the European Union (EU) due to the presence of
N
-nitrosodimethylamine (NDMA) impurities, which were considered to be carcinogenic. The aim of this study was to investigate … Show more
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