Drug Use in Pregnancy: Obstetric Perspectives

Evans, Arthur T.; Gillogley, K.M.

doi:10.1016/s0095-5108(18)30532-3

Cited by 14 publications

(3 citation statements)

References 27 publications

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“…Obesity is known to induce impairment of renal function (12,15,28,45). In the present study, the ability to excrete sodium was impaired in Fat rats during 9% NaCl infusion.…”

Section: Discussionsupporting

confidence: 43%

Reduced carotid baroreceptor distensibility-induced baroreflex resetting contributes to impairment of sodium regulation in rats fed a high-fat diet

Abe

Nagai

Yamaguchi

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Decreased carotid arterial compliance has been reported in obese subjects and animals. Carotid baroreceptors are located at the bifurcation of the common carotid artery, and respond to distension of the arterial wall, suggesting that higher pressure is required to obtain the same distension in obese subjects and animals. A hyperosmotic NaCl solution induces circulatory volume expansion and arterial pressure (AP) increase, which reflexively augment renal excretion. Thus, we hypothesized that sodium regulation via the baroreflex might be impaired in response to chronic hyperosmotic NaCl infusion in rats fed a high-fat diet. To examine this hypothesis, we used rats fed a high-fat (Fat) or normal (NFD) diet, and measured mean AP, water and sodium balance, and renal function in response to chronic infusion of hyperosmotic NaCl solution via a venous catheter. Furthermore, we examined arterial baroreflex characteristics with static open-loop analysis and distensibility of the common carotid artery. Significant positive water and sodium balance was observed on the 1st day of 9% NaCl infusion; however, this disappeared by the 2nd day in Fat rats. Mean AP was significantly higher during 9% NaCl infusion in Fat rats compared with NFD rats. In the open-loop analysis of carotid sinus baroreflex, a rightward shift of the neural arc was observed in Fat rats compared with NFD rats. Furthermore, distensibility of the common carotid artery was significantly reduced in Fat rats. These results indicate that a reduced baroreceptor distensibility-induced rightward shift of the neural arc might contribute to impairment of sodium regulation in Fat rats.

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“…Obesity is known to induce impairment of renal function (12,15,28,45). In the present study, the ability to excrete sodium was impaired in Fat rats during 9% NaCl infusion.…”

Section: Discussionsupporting

confidence: 43%

Reduced carotid baroreceptor distensibility-induced baroreflex resetting contributes to impairment of sodium regulation in rats fed a high-fat diet

Abe

Nagai

Yamaguchi

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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“…97 Poor nutrition during pregnancy, potentially affecting fetal growth, is also common with chronic cocaine use, owing to the anorectic effects of cocaine. 37 Drug use in women is associated with increased incidence of infectious diseases, especially sexually transmitted diseases (STDs) and human immunodeficiency viruses (HIVs). In a survey of cocaine-using women, Fullilove et al 50 reported 55% had a history of STD.…”

Section: Pharmacology and Obstetric Complicationsmentioning

confidence: 99%

Neurodevelopmental Effects of Cocaine

Singer

Arendt

Minnes

1993

Clinics in Perinatology

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How and to what extent fetal cocaine exposure produces specific, negative, long-term effects on infant neurodevelopmental competence has not yet been determined. We have argued previously that results from animal studies, the findings of intrauterine growth retardation in human studies, and the markedly higher incidence of numerous associated risk factors in cocaine-exposed cohorts herald significant clinical risk to the developing infant. Recognition of infant risk status should not imply condemnation of a group of children but, as with preterm infants, lead to aggressive, national, social, and scientific efforts to delineate and intervene with potential sequelae of drug exposure.

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“…В развитии ВМК значение имеют еще 2 фактора: кокаин и алкоголь. По данным исследований от 8 до 17% беременных женщин употребляют кокаин [15], и все эти случаи осложняются во время беремен ности, как ВК, так и СК из разорвавшейся аневризмы [18,22,23,48]. Описан случай ВМК у беременной, при нимавшей метамфетамин [34].…”

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Intracerebral Hemorrhage in Eclampsia

Туманян¹

2008

rmt

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Drug Use in Pregnancy: Obstetric Perspectives

Cited by 14 publications

References 27 publications

Reduced carotid baroreceptor distensibility-induced baroreflex resetting contributes to impairment of sodium regulation in rats fed a high-fat diet

Reduced carotid baroreceptor distensibility-induced baroreflex resetting contributes to impairment of sodium regulation in rats fed a high-fat diet

Neurodevelopmental Effects of Cocaine

Intracerebral Hemorrhage in Eclampsia

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