Drug Usage Pattern in Chronic Kidney Disease patients undergoing maintenance Hemodialysis

Pothen, Christina; Baby, Bibin; Ashokan, Anusree; Chacko, Chinju Susan; Shenoy, Pradeep; Up, Nandakumar

doi:10.5958/0974-360x.2019.00872.2

Cited by 10 publications

(1 citation statement)

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“…Such patients are most of the time taking polypharmacy prescriptions and are more at risk of drug-drug interaction and adverse drug reactions. There is a dire need to make the proper and suitable selection of drugs to avoid unwanted effects and ensure optimum patient outcomes (Ahlawat et al, 2015;Pothen et al, 2019). Some of the complexities, such as CVS, Anemia, and High blood pressure, need sound management (Tamilselvan et al, 2014) and approach, which can trigger several other complications and worsen kidney functions, ultimately adversely altering the quality of life (Bajait et al, 2014;Santra et al, 2014;Saeed et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Drug Prescribing Trends and Drug-Drug Interactions among Chronic Kidney Disease Patients

Memon¹,

Khoso²,

Ateya³

et al. 2022

J Biochem Technol

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Chronic kidney disease (CKD) is a challenging problem for medicine to overcome. The renal disorder is frequently misdiagnosed; nevertheless, attempts are being made to enhance the identification and treatment of patients with this comorbidity. The objective of the present study was to assess the prescribing patterns and drug/drug interactions among patients suffering from CKD and renal transplantation. About 300 patients were recruited after following the inclusion and exclusion criteria, and the prospective observational study was carried out for a period of six months at the tertiary care Hospital Larkana. The sample comprised 63% males and 37% females, and the primary age group was 65-75 years 31.66%. The major comorbidities were Diabetes Mellitus 22.33% and Hypertension 19.66%. Besides, 89% were CKD, and 11% were transplantation patients. The present study made detailed research on the drugs prescribed in CKD and Transplantation cases, and most of the drugs were prescribed with trade names and without following the WHO guidelines, which triggered the serious DDIs.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Drug Prescribing Trends and Drug-Drug Interactions among Chronic Kidney Disease Patients

Memon¹,

Khoso²,

Ateya³

et al. 2022

J Biochem Technol

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Indoleamine 2,3-dioxygenase level and oxidative stress parameters in the serum of patients with chronic renal failure

Saeed,

Jasim

2023

Ukr.Biochem.J.

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Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme belonging to the kynurenine pathway. IDO activity has been suggested as a biomarker for diagnosis of chronic kidney disease. The aim of the study was to estimate the level of IDO, urea, creatinine, uric acid, phosphate, calcium, albumin, MDA, GSH, and activity of peroxidase, catalase, arylesterase in the serum of chronic renal failure (CRF) patients treated with dialysis compared to the healthy control group. The results showed a significant increment in IDO level in patients compared with the control. Linear regression analysis using the Pearson correlation coefficient showed that increased IDO level correlates positively with urea, creatinine, uric acid, phosphate, MDA level and peroxidase activity whereas negatively with albumin, calcium, glutathione level, catalase activity and glomerular filtration rate. We concluded that IDO level might be a possible marker of oxidative stress and inflammation in patients with CRF. Keywords: 3-dioxygenase, biochemical parameters, correlation analysis, indoleamine 2, renal failure, serum

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Biochemical Investigation to Determine the Factors Involved in Renal Failure Formation for Dialysis Patients

Joudah¹,

Saleh²,

Joudah³

et al. 2021

RJPT

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Renal failure is on the top list of kidney diseases as being frequently reported in many medical facilities around the globe. Human kidneys play an important role in excreting, reabsorbing, secreting and filtrating substances in the body. Healthy kidney must excrete the waste products of the body in urine and preserve albumin, and other useful substances in the body. The current study aims to figure out the expected factors of renal failure formation in dialysis patients. Likewise, it is designed to search for any correlation between the imbalanced levels of electrolytes and kidney deterioration. The current study was conducted in Ramadi city-Iraq with the assistance of Al-Ramadi Educational Hospital (REH). The (14th) samples of renal failure patients were collected from dialysis unit at (REH). (2-3 mL) of blood was taken from a patient’s vein. The serum was separated from plasma with the use of a centrifuge. All samples were undergone centrifuging for (4-7 min) at (550 rpm). Afterward, samples were subjected to biochemical examinations to determine the levels and quantities of some biochemical elements and other substances in the selected cases. It was found that some patients had been recorded with a decrease in glomerular filtration rate (GFR), high HbA1c level (˃ 6.5 mg/dL) (21.5%), anemia (˂ 12.0 mg/dL) (%100) in women and (˂ 13.5 mg/dL) in men (%100), Uremia (˃ 45mg/dL) (%100), hypercalcemia (˃10.5 mg/dL) (%7.14), hyperkalemia (˃ 5.1 mg/dL) (%92.8), and Hypernatremia (˃145 mg/dL) (%28.5). Some results obtained, imbalanced levels of the mentioned substances, are either progressed with kidney deterioration, or they are the causes of renal failure. Changes in the levels of some blood substances were observed, and positive results were obtained regarding the aim of the study. Levels or quantities of some blood substances play an important role in preserving kidneys good performance. For instance, when the level of glucose in blood raises, a severe damage to the blood vessels of the kidney takes place and results in poor kidney's performance. While, an increment in the K serum level causes a sudden cardiac death. Changing in some levels and quantities of blood substances could be a core cause of renal failure formation, however, some of them develops when kidney deteriorates.

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Drug Usage Pattern in Chronic Kidney Disease patients undergoing maintenance Hemodialysis

Cited by 10 publications

References 0 publications

Evaluation of Drug Prescribing Trends and Drug-Drug Interactions among Chronic Kidney Disease Patients

Evaluation of Drug Prescribing Trends and Drug-Drug Interactions among Chronic Kidney Disease Patients

Indoleamine 2,3-dioxygenase level and oxidative stress parameters in the serum of patients with chronic renal failure

Biochemical Investigation to Determine the Factors Involved in Renal Failure Formation for Dialysis Patients

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