Drug therapy and adverse drug reactions to terbutaline in obstetric patients: a prospective cohort study in hospitalized women

Hernández-Hernández, Dulce Marı́a; Vargas-Rivera, María Josefa E; Nava-Ocampo, Alejandro A; Palma-Aguirre, José Antonio; Sumano-López, Héctor

doi:10.1186/1471-2393-2-3

Cited by 5 publications

(5 citation statements)

References 44 publications

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“…Published studies on ADR in pregnancy have shown very different prevalences among them, with estimates ranging between 0.3 and 20.0% [14, 16]. The only Brazilian work on the topic [17] reported that 8.8% women from a sample of 294 high-risk hospitalized pregnant women suffered an ADR.…”

Section: Discussionmentioning

confidence: 99%

“…The only Brazilian work on the topic [17] reported that 8.8% women from a sample of 294 high-risk hospitalized pregnant women suffered an ADR. Hernández-Hernández et al [16], in a Mexican cohort of 207 pregnant women, observed ADR in 12.1%. In contrast, a French study found ADR in only 0.3% of pregnancies, but data on ADR were obtained by self-reporting [20].…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have estimated the incidence of ADR during pregnancy at around 10% [14, 16, 17], but in general they were based on small samples and the identification of ADR was not through active search. In addition, the drugs involved and the clinical manifestations of ADR have not been adequately described and, to the best of our knowledge, no studies have yet attempted to identify risk factors for the occurrence of ADR.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and profile of adverse drug reactions in high-risk pregnancy: a cohort study

Silva

Fernandes

Pessoa

et al. 2019

BMC Pregnancy Childbirth

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Background C ommonly used drugs in pregnant women include antihypertensives, hypoglycemic agents, analgesics, antimicrobials, antiemetics and antispasmodics but the use of medicines during pregnancy, especially in high-risk pregnancy, may be associated with high risk of adverse drug reactions (ADR). The objective of this study was to determine the risk of an adverse drug reaction in hospitalized high-risk pregnant women and the factors associated with their occurrence. Methods The study received IRB approval and all patients gave written informed consent. Observational cohort study conducted from September 2015 to November 2016 in 1070 pregnant women consecutively admitted to the high risk sector of the University Maternity Januário Cicco in Brazil. ADR were detected through daily active search. Risk factors for the occurrence of ADR were determined using multivariate logistic regression. Results The mean age of the study population was 26.2 ± 7.2 years and gestational age was 31.2 ± 7.2 weeks. The average number of previous pregnancies was 2.4 ± 1.8 and 46.4% reported cases of previous abortion/miscarriage. ADR were observed in 10.7% of women. The main medicines involved, with the incidence rate of ADR per 100 prescriptions of the drug (IR), were parenteral scopolamine (IR 14.9%), methyldopa (IR 15.9%), insulin (IR 8.46%), oral scopolamine (IR 3.58%), captopril (IR 2.38%) and ceftriaxone (IR 18.4%). Multivariate analysis showed that only gestational age in weeks (odds-ratio 0.97, 95% confidence interval 0.95–0.98) was related to the occurrence of adverse reactions. Conclusion Lower gestational age is a risk factor for high-risk pregnant women, increasing the likelihood of adverse reactions, with parenteral medications being those that have the highest potential risk of harm. Electronic supplementary material The online version of this article (10.1186/s12884-019-2321-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and profile of adverse drug reactions in high-risk pregnancy: a cohort study

Silva

Fernandes

Pessoa

et al. 2019

BMC Pregnancy Childbirth

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“…Only eleven studies analyzing drug prescriptions were carried out in hospitals. [44][45][46][47][48][49][50][51][52][53][54][55] What do these findings mean for the design and implementation of a new pharmaceutical policy in Mexico? The results indicate three priority areas for a new national pharmaceutical policy to address: a) strategies to combat irrational prescribing and consumption of medicines, b) strategies to improve access to medicines, and c) the promotion of sound nation-wide research on access and use of medicines, in order to inform the development of current and future policies.…”

Section: Discussionmentioning

confidence: 99%

Medicines in Mexico, 1990-2004: systematic review of research on access and use

Wirtz¹,

Reich²,

Flores³

et al. 2008

Salud pública Méx

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Objective. To review original research studies published between 1990 and 2004 on the access and use of medicines in Mexico to assess the knowledge base for reforming Mexico's pharmaceutical policy. Material and Methods. A literature review using electronic databases was conducted of original studies published in the last 15 years about access and use of medicines in Mexico. In addition, a manual search of six relevant journals was performed. Excluded were publications on herbal, complementary and alternative medicines. Results. Were identified 108 original articles as being relevant, out of 2 289 titles reviewed, highlighting four policy-related problems: irrational prescribing, harmful self-medication, inequitable access, and frequent drug stock shortage in public health centers. Conclusions. This review identified two priorities for Mexico's pharmaceutical policy and strategies: tackling the irrational use of medicines and the inadequate access of medicines. These are critical priorities for a new national pharmaceutical policy.

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“…Considering previous prevalence studies in which ADR in pregnant inpatients ranged from 0.3% to 12.1%, as well as absolute accuracy of 5% and confidence interval of 95%, a minimum sample of 162 individuals was determined (Lacroix et al, 2007, Hernández-Hernández et al, 2002). Data analysis was performed using SPSS software, release 12.…”

Section: Methodsmentioning

confidence: 99%