Drug targeting using non-magnetic and magnetic albumin-globulin mix microspheres of mefenamic acid

Abstract

Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemical parameters of the microspheres such as density, particle size distribution, surface topography and wall thickness, as well as the magnetite contained within the magnetic microspheres, have been determined. The infrared spectroscopic analysis confirmed the encapsulation of the drug and absence of free drug on the surface of the microspheres. The X-ray diffraction analysis confirmed that the crystallinity of the drug remained unchanged indicating thereby that no complex formation had taken place between core and coat materials. The in vitro release profiles of the microspheres have been studied. An attempt has also been made to check the in vivo efficacy in rats.

Biopolymer albumin for diagnosis and in drug delivery

“…Higher h values (almost double) were reported [Lalla and Ahuja, 1991] when Equation 2 is used as compared to Equation 3.…”

“…They also proved that the membrane structure becomes more porous in the internal layers, which have not reacted completely with the crosslinking agent. A comparison of the SEM of thermally and chemically stabilized alglomix (alblumin+half yolk from egg) MS loaded with mefanamic acid [Lalla and Ahuja, 1991] clearly differentiates the former from the latter, which is almost spherical and shows a porous character, as seen in Figure 9A,B, respectively.…”

“…Scanning electron micrographs of alglomix microsphere loaded with mefanamic acid prepared by thermal (A, 1500 Â ) and chemical (B, 600 Â ) stabilization. Reproduced fromLalla and Ahuja [1991] by permission of Taylor & Francis Ltd., http://www.tandf.co.uk/ journals.…”

Studies on Mefenamic Acid Microparticles: Formulation, In Vitro Release, and In Situ Studies in Rats

“…Sustained release MA microspheres (5,6), MA matrix tablets (7,8), and controlled release MA-loaded alginate beads (9) have been reported in the literature. MA is classified as class II on the basis of the biopharmaceutical classification system (10,11) because of its poor solubility over the pH range 1.2-7.5 [solubility=0.2 μg/mL (pH 1.2), 0.12 mg/mL (pH 7.5)] (12,13) and high permeability in Caco-2 cell model (13).…”