Drug Targeting in IBD Treatment – Existing and New Approaches

Goračinova, Katerina; Dodov, Marija Glavaš; Crcarevska, Maja Simonoska; Geškovski, Nikola

doi:10.5772/29278

Cited by 4 publications

(1 citation statement)

References 135 publications

(108 reference statements)

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“…To reach the highest level of efficacy of an administered drug, two factors need to be considered, namely; the ability of the drug to present itself to the body at a specific required rate and to direct the active entity of the drug specifically to the site of action thereby increasing the action of the drug and reducing the side effects (Wikberg et al, 1997). It is generally accepted concept that the efficacy of the drug is enhanced by the delivery of the active substance at the site of infection (Goracinova et al, 2012). Normally, drugs follow the standard process of absorption, distribution, metabolism and elimination after administration.…”

Section: Nanotechnology Based Drug Delivery Approaches For Mapmentioning

confidence: 99%

Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases

Stephen¹,

Jain²,

Dhama³

et al. 2015

Asian J. of Animal and Veterinary Advances

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Johne's Disease (JD) is a contagious fatal granulomatous enteritis, known to affect ruminants and is caused by the acid-fast Mycobacterium avium subspecies paratuberculosis (MAP). The bacterium has also been linked to Crohn's Disease (CD) in humans. Treatment options are scarce with culling practiced in the case of Johne's Disease (JD) and administration of anti-inflammatory drugs for pain and inflammation in case of CD. In both cases antimicrobial therapy against MAP does not have the ultimate potential. The very promising, yet untapped potential of nanotechnology offers a suitable platform for developing new therapeutic strategies for diseases caused by the bacteria. Uniformity, specificity and reproducibility are some of the characteristics of nanotechnology that can be exploited for the treatment of infectious diseases. Factors like cost, efficacy, safety and bioavailability of drugs can be greatly improved when the drugs are delivered with precision and at a controlled delivery rate to the target location. Nanotechnology can help in achieving these targets. This review discusses the current scenario of available therapeutic approaches and proposes drugs targeting strategies and vaccine development methods for the treatment and prevention of MAP related diseases.

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Section: Nanotechnology Based Drug Delivery Approaches For Mapmentioning

confidence: 99%

Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases

Stephen¹,

Jain²,

Dhama³

et al. 2015

Asian J. of Animal and Veterinary Advances

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Colon Targeted Rifaximin Nanosuspension for the Treatment of Inflammatory Bowel Disease (IBD)

Kumar¹,

Amaldoss

2016

AIAAMC

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The outcome of this research work confirms the formation of nanoparticles and release profile of the prepared nanosuspension proved its site specificity. The release graphs indicated the release of the drug in colon proving its potential in the treatment of IBD and entrapment study indicates the drug entrapment capacity for delivering the required concentration of drug at the site of action. Moreover, the nanoformulation reduces the dose and the side effects due to its specific targeting at the site of inflammation which makes it a better choice over the tablets.

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IBD Modern Concepts, Nano Drug Delivery and Patents: An Update

Kumar¹,

Newton

2015

PNM

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Drug Targeting in IBD Treatment – Existing and New Approaches

Cited by 4 publications

References 135 publications

Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases

Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases

Colon Targeted Rifaximin Nanosuspension for the Treatment of Inflammatory Bowel Disease (IBD)

IBD Modern Concepts, Nano Drug Delivery and Patents: An Update

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