Drug Susceptibility Assessment in Stenotrophomonas Maltophilia Strains Isolated From the Blood of Organ Transplantation Recipients in a Warsaw Teaching Hospital During 2011 to 2014

Usarek, Paulina; Dobrzaniecka, K.; Szymanek-Majchrzak, Ksenia; Sawicka-Grzelak, A.; Młynarczyk, A; Durlik, M.; Ciszek, Michał; Pączek, Leszek; Chmura, A.; Kwiatkowski, A.; Młynarczyk, G.

doi:10.1016/j.transproceed.2016.01.072

Cited by 5 publications

(7 citation statements)

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“…Fluoroquinolone resistance is associated with several mechanisms including the chromosomally encoded qnr gene [64], mutations of the bacterial topoisomerase and gyrase genes [65], and the efflux pump SmeDEF [66]. Although fluoroquinolone resistance rates of S. maltophilia have been reported to be increasing since the 1990s [67], in recent studies, they vary depending on region and centre [6,68,69]. It is well known that fluoroquinolone resistance increases in association with overall fluoroquinolone use [67,70], so fluoroquinolone usage should be controlled in hospitalized patients.…”

Section: Discussionmentioning

confidence: 99%

Fluoroquinolones versus trimethoprim-sulfamethoxazole for the treatment of Stenotrophomonas maltophilia infections: a systematic review and meta-analysis

Kang

Cornejo‐Juárez

et al. 2019

Clinical Microbiology and Infection

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Background: Fluoroquinolones are a popular alternative to trimethoprim-sulfamethoxazole for Stenotrophomonas maltophilia infections. Objectives: To compare the effects of fluoroquinolones and trimethoprim-sulfamethoxazole on mortality of S. maltophilia infections. Data sources: PubMed and EMBASE. Study eligibility criteria: Clinical studies reporting mortality outcomes of S. maltophilia infections. Participants: Patients with clinical infections caused by S. maltophilia. Interventions: Fluoroquinolone monotherapy in comparison with trimethoprim-sulfamethoxazole monotherapy.Methods: Systematic review with meta-analysis technique. Results: Seven retrospective cohort and seven caseecontrol studies were included. Three cohort studies were designed to compare the two drugs, whereas others had other purposes. A total of 663 patients were identified, 332 of which were treated with trimethoprim-sulfamethoxazole (50.1%) and 331 with fluoroquinolones (49.9%). Three cohort studies were designed to compare the effect of the two drugs, whereas the others had other purposes. Levofloxacin was most frequently used among fluoroquinolones (187/331, 56.5%), followed by ciprofloxacin (114/331, 34.4%). The overall mortality rate was 29.6%. Using pooled ORs for the mortality of each study, fluoroquinolone treatment (OR 0.62, 95% CI 0.39e0.99) was associated with survival benefit over trimethoprim-sulfamethoxazole treatment, with low heterogeneity (I 2 ¼ 18%). Specific fluoroquinolones such as ciprofloxacin (OR 0.44, 95% CI 0.17e1.12) and levofloxacin (OR 0.78, 95% CI 0.48e1.26) did not show a significant difference in comparison with trimethoprimsulfamethoxazole. In the sub-group analyses of adult and bacteraemic patients, significant differences in mortality were not observed between fluoroquinolones and trimethoprim-sulfamethoxazole.

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Section: Discussionmentioning

confidence: 99%

Fluoroquinolones versus trimethoprim-sulfamethoxazole for the treatment of Stenotrophomonas maltophilia infections: a systematic review and meta-analysis

Kang

Cornejo‐Juárez

et al. 2019

Clinical Microbiology and Infection

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“…Stenotrophomonas maltophilia , Burkholderia cepacia complex (BCC), and Achromobacter xylosoxidans are less common causes of infections compared to other non-fermentative Gram-negative bacilli but are pathogens of concern in SOT recipients [ 99 ]. They are ubiquitous in the environment, specifically water and soil, and are known to cause severe infections, especially in people with underlying pulmonary conditions and in immunocompromised hosts [ 100 , 101 , 102 ].…”

Section: Resultsmentioning

confidence: 99%

Epidemiology and Prevention of Early Infections by Multi-Drug-Resistant Organisms in Adults Undergoing Liver Transplant: A Narrative Review

et al. 2023

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Invasive bacterial infections are a leading cause of morbidity and mortality after liver transplant (LT), especially during the first months after LT, and infections due to multi-drug-resistant organisms (MDRO) are increasing in this setting. Most of the infections in patients in intensive care unit arise from the endogenous microflora and, for this reason, pre-LT MDRO rectal colonization is a risk factor for developing MDRO infections in the post-LT. Moreover, the transplanted liver may carry an increased risk of MDRO infections due to organ transportation and preservation, to donor intensive care unit stay and previous antibiotic exposure. To date, little evidence is available about how MDRO pre-LT colonization in donors and recipients should address LT preventive and antibiotic prophylactic strategies, in order to reduce MDRO infections in the post-LT period. The present review provided an extensive overview of the recent literature on these topics, with the aim to offer a comprehensive insight about the epidemiology of MDRO colonization and infections in adult LT recipients, donor-derived MDRO infections, possible surveillance, and prophylactic strategies to reduce post-LT MDRO infections.

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“…The proportion of strains resistant to SXT was obviously altered from 29.7% in 2005 -2009 to 47.1% in 2010 -2014 in Anhui province, China (29). Twenty-six S. maltophilia isolated from blood were sensitive to ceftazidime (53.9%), ticarcillin/clavulanic acid (80.8%), ciprofloxacin (92.3%), levofloxacin (96.2%), and trimethoprim/sulfamethoxazole (100%) in War-saws (30).…”

Section: Discussionmentioning

confidence: 99%

“…Stenotrophomonas maltophilia demonstrated higher antibiotic resistance to cefepime (32.1%), amikacin (42.3%), cefotaxime (51.5%), ceftazidime (52.3%), gentamicin (55.1%) and meropenem (93.4%), and lower resistance to levofloxacin (2.6%), chloramphenicol (14.3%), SXT (25.0%), and ciprofloxacin (26.0%) in Mexico (30).…”

Section: Discussionmentioning

confidence: 99%

“…Early recognition of S. maltophilia is particularly significance. The use of antibiotics to which this microorganism is ingenious wipes out the infection and alleviates avoid graft failure (30). Exact recognition and susceptibility programs of S. maltophilia are essential for the supervision of infected patients and avoidance of transmit of this nosocomial microorganism (34).…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic Resistance Surveillance of Clinical Isolates of Stenotrophomonas maltophilia Strains in the Central South of China from 2016 to 2019

Yang

Yan

Chen

et al. 2020

Jundishapur J Microbiol

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Background: Due to the difficulty of treatment caused by its numerous mechanisms of resistance, only four kinds of antibiotics are recommended for the therapy of Stenotrophomonas maltophilia infections associated with significant morbidity and mortality. Objectives: In this four-year study, we aimed to determine the evolution of drug resistance to S. maltophilia base on drug classification guidelines recommended by the Institute of Clinical and Laboratory Standards. Methods: A total of 1876 strains of S. maltophilia was separated from multifarious clinical specimens among January 2016 and December 2019. VITEK 2 Compact microbial system was used for speciation level identification and antibiotic sensitivity test. Results: A total of 1876 strains of S. maltophilia strains were separated from sputum specimen type (70.63%), Followed by bronchial (6.18%), blood (4.16%), and bronchoalveolar lavage samples (4.32%). Moreover, 695 strains of S. maltophilia strains were separated from intensive care unit (ICU) department (37.05%), and then neurosurgery ward (10.66%), integrative Chinese and western medicine ward (7.25%), general surgery ward (6.66%). The results of minocycline antibiotic of S. maltophilia with a drug resistance rate of 0.3%. From 2016 to 2019, the resistance rate of cefoperazone/sulbactam decreased from 20.8% to 15.2%, the resistance rate of trimethoprimsulfametoxasole decreased from 7.9% to 4.5%. The resistance rate of minocycline fluctuate in 0.0%% between 0.7%. However, the resistance rate of levofloxacin increased from 7.7% to 8.0%. Conclusions: In this study, S. maltophilia was detected in a variety of specimen types of different clinical departments, with the most detected in ICU patients and sputum specimen. S. maltophilia was sensitive to minocycline and levofloxacin, but the situation of cefoperazone/sulbactam resistance was not optimistic. The results of this study indicate that minocycline is considered to be the most effective antibiotic for the treatment of S. maltophilia. Therefore, we still need to strengthen the drug resistance monitoring, timely acquisition of S. maltophilia drug resistance changes, and actively take effective measures to deal with the drug resistance of S. maltophilia.

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Drug Susceptibility Assessment in Stenotrophomonas Maltophilia Strains Isolated From the Blood of Organ Transplantation Recipients in a Warsaw Teaching Hospital During 2011 to 2014

Cited by 5 publications

References 11 publications

Fluoroquinolones versus trimethoprim-sulfamethoxazole for the treatment of Stenotrophomonas maltophilia infections: a systematic review and meta-analysis

Fluoroquinolones versus trimethoprim-sulfamethoxazole for the treatment of Stenotrophomonas maltophilia infections: a systematic review and meta-analysis

Epidemiology and Prevention of Early Infections by Multi-Drug-Resistant Organisms in Adults Undergoing Liver Transplant: A Narrative Review

Antibiotic Resistance Surveillance of Clinical Isolates of Stenotrophomonas maltophilia Strains in the Central South of China from 2016 to 2019

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