Drug-Specific Effects of Volatile Anesthetics on Ca2+ Sensitization in Airway Smooth Muscle

Kai, Tetsuya; Bremerich, Dorothee H.; Jones, Keith A.; Warner, David O.

doi:10.1213/00000539-199808000-00036

Cited by 16 publications

(18 citation statements)

References 20 publications

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“…The results of WIKLUND et al [18], but not those of FUKUSHIMA et al [14], support this hypothesis. It would be also in accordance with the ability of volatile anaesthetics to attenuate calcium sensitisation [15]. Further studies using human bronchi will be useful to clarify the issue.…”

Section: Discussionmentioning

confidence: 71%

“…Very recently, T-type Ca 2z channels have also been implicated in the relaxation of porcine distal (but not proximal) airway smooth muscle induced by isoflurane and sevoflurane [19]. Inhibition of G-proteins dissociation by halothane with subsequent increase in protein phosphatase activity has also been demonstrated [31] and this accounts for attenuation of Ca 2z sensitisation previously reported [15]. Finally, it has been demonstrated that halothane (at least) induces depletion of sarcoplasmic reticulum Ca 2z content via increased Ca 2z leak through both inositol trisphosphate (IP 3) receptor and ryanodine receptor channels [32].…”

Section: Discussionmentioning

confidence: 77%

“…There are many studies available on the relaxant effects produced by volatile anaesthetics directly administered in vitro on isolated airway smooth muscle [8][9][10][11][12][13][14][15][16][17][18][19]. However, few of them have been performed on distal airway smooth muscle [13,16,17,19] or have involved desflurane [13,17,18].…”

Section: Discussionmentioning

confidence: 99%

“…For example, in dogs in vivo, the direct relaxant effect of halothane on airway smooth muscle contributed as much as the indirect effect on the vagal pathway [4]. These direct relaxant effects in vivo have been reproduced in vitro in many animal studies [8][9][10][11][12][13][14][15][16][17][18][19]. However, the intensity of the relaxation in vitro varies widely among studies.…”

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confidence: 99%

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Relaxation of proximal and distal isolated human bronchi by halothane, isoflurane and desflurane

Mercier¹,

Naline²,

Bardou³

et al. 2002

Eur Respir J

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Volatile anaesthetics relax airway smooth muscle in vitro. The amount of relaxation might depend on the type and concentration of volatile anaesthetics, the calibre and precontraction level of the bronchi, and also on the species considered. These effects were investigated on isolated human bronchi.Isometric relaxations produced by halothane, isoflurane and desflurane bubbled on human bronchial rings precontracted with carbachol were recorded and compared with time controls.Volatile anaesthetics induced a concentration-dependent relaxation at 0.66, 1.33 and 2 minimum alveolar concentration (MAC). The relaxation was greater in mildly (carbachol 3610 -7 M) than in highly (carbachol 2610 -6 M) precontracted bronchi. Halothane was more potent in relaxing distal as compared to proximal bronchi; this differential effect was less pronounced with isoflurane and not observed with desflurane. While the three volatile anaesthetics induced similar relaxation on proximal bronchi, halothane was significantly more potent than desflurane on distal bronchi, with isoflurane being intermediate. The relaxation induced by 1.33 MAC of halothane, isoflurane and desflurane on moderately precontracted distal bronchi (carbachol 1610 -6 M) was attenuated by pretreatment with glibenclamide 1610 -5 M. In conclusion, halothane, isoflurane and desflurane exert direct but differential relaxant effects on human isolated bronchial smooth muscle. This may provide supplemental bronchodilation during anaesthesia. Although adenosine triphosphatesensitive K z channels are involved in these relaxant effects, they are unlikely to explain the observed differences between the three volatile anaesthetics. Eur Respir J 2002; 20: 286-292. Halothane and isoflurane are well-established bronchodilators in vivo both in animals [1][2][3][4][5] and humans [6,7]. Part of this bronchodilation is due to a direct effect on airway smooth muscle. For example, in dogs in vivo, the direct relaxant effect of halothane on airway smooth muscle contributed as much as the indirect effect on the vagal pathway [4]. These direct relaxant effects in vivo have been reproduced in vitro in many animal studies [8][9][10][11][12][13][14][15][16][17][18][19]. However, the intensity of the relaxation in vitro varies widely among studies. Factors that may explain these variations include: 1) anaesthetic concentration; 2) level of precontraction and contractile agonist used [11]; 3) airway calibre [13,19,20]; 4) differences in efficacy between volatile anaesthetics [7,13,17,20]; and 5) animal species. This latter factor might be particularly important, and so far, no in vitro studies involving volatile anaesthetics appear to be available on human airway smooth muscle.Desflurane, a more recent volatile anaesthetic, has some interesting properties including rapid onset/ offset of action. However, breath-holding, partial laryngospasm and coughing have been reported during induction of anaesthesia with desflurane in humans [21]. Such irritant effects on the upper airways do not seem...

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Relaxation of proximal and distal isolated human bronchi by halothane, isoflurane and desflurane

Mercier¹,

Naline²,

Bardou³

et al. 2002

Eur Respir J

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“…Many previous studies have focused on the cellular mechanisms of action of volatile anaesthetics on airway smooth muscle cell cultures (12,13,17,(27)(28)(29) or isolated tracheal and/or bronchial rings (5-8, 30, 31). The structural integrity of the lungs has been lost in such investigations, which makes it difficult to extrapolate these findings to an organ level.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Modulation of airway and lung tissue mechanics by different intrapulmonary resident gases

Enikő

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Background: Bronchoactive properties of volatile agents against lung constriction are well established. The purpose of this study was to investigate the ability of halothane (Hal), isoflurane (Iso), sevoflurane (Sev) and desflurane (Des) to alter the lung mechanics in the absence of an airway tone and during acetylcholine (Ach)-induced bronchoconstriction. Methods: Low-frequency pulmonary impedance data (Z L ) were collected from isolated, normo-perfused rat lungs under baseline conditions and following the injection of Ach (0.1 mg/kg) into the pulmonary artery. Measurements were performed without the administration of any anaesthetic agent in the first phase of the experiments and during inhalation without any volatile agent (control group, n ¼ 6) or during inhalation of Hal (n ¼ 6), Iso (n ¼ 9), Sev (n ¼ 6) or Des (n ¼ 8) at 1 minimum alveolar concentration (MAC). The airway resistance (R aw ) and parenchymal damping and elastance were estimated from the Z L data by model fitting. Results: Under baseline conditions, the basic value of R aw was significantly decreased by Des (-31.2 AE 3.8%) and Sev (-18.0 AE 4.5%) administration, whereas Hal and Iso did not have

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Factors That Can Influence Animal Research

Baker

Lipman

2015

Laboratory Animal Medicine

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Drug-Specific Effects of Volatile Anesthetics on Ca2+ Sensitization in Airway Smooth Muscle

Cited by 16 publications

References 20 publications

Relaxation of proximal and distal isolated human bronchi by halothane, isoflurane and desflurane

Relaxation of proximal and distal isolated human bronchi by halothane, isoflurane and desflurane

Modulation of airway and lung tissue mechanics by different intrapulmonary resident gases

Factors That Can Influence Animal Research

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