Drug Side Effect Symptoms and Adherence to Antihypertensive
          Medication

Tedla, Yacob; Bautista, Leonelo E.

doi:10.1093/ajh/hpv185

Cited by 116 publications

(90 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previously, we have shown that hypertensive patients who experienced ≥4 drug-related side effect symptoms were more likely to become non-adherers (PCAR<80%). 21 Also, it has been found that a high percentage of patients (85%) who experience drug related side effects share their concerns about side effects with their physicians. 31 This suggests that patients with side effects may be also more open to admit not taking medication as prescibed, since they may not perceive a lack of adherence as their personal failure.…”

Section: Discussionmentioning

confidence: 99%

“…This scoring approach has been successfully used in previous studies among hypertensive patients. 20, 21 …”

Section: Methodsmentioning

confidence: 99%

“…Pill count adherence ratio (PCAR) was calculated as the proportion of pills taken out of the total number of pills prescribed between two consecutive visits, i.e., (pills taken ÷ pills prescribed)×100. 21 Following current practice, participants were considered adherent if they took ≥80% of the prescribed number of pills (PCAR≥80%). This cut-point has been shown to correlate well with urinary levels of diuretics and changes in blood pressure.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Factors associated with false-positive self-reported adherence to antihypertensive drugs

Tedla

Bautista²

2016

J Hum Hypertens

View full text Add to dashboard Cite

Self-reported medication adherence is known to overestimate true adherence. However, little is known about patient factors that may contribute to the upward bias in self-reported medication adherence. The Objective of this study is to examine whether demographic, behavioral, medication, and mood factors are associated with being a false positive self-reported adherer (FPA) to antihypertensive drug treatment. We studied 175 patients (mean age: 50 years; 57% men) from primary care clinics starting antihypertensive drug treatment. Self-reported adherence was measured with the medication adherence report scale (MARS) and by the number of drug doses missed in the previous week/month and compared to pill count adherence (PCAR) as gold standard. Data on adherence, demographic, behavioral, medication, and mood factors were collected at baseline and every three months up to 1 year. FPA was defined as being non-adherer by PCAR and adherer by self-report. Mixed effect logistic regression was used for the analysis. Twenty percent of participants were FPA. Anxiety increased (odds ratio -OR: 3.00; P=0.01), while smoking (OR: 0.40; P=0.03), and drug side effects (OR: 0.46, P=0.03) decreased the probability for FPA by MARS. An educational below completed high school increased the probability of being a FPA as measured by missing doses in the last month (OR: 1.66; P=0.04) and last week (OR: 1.88; P=0.02). The validity of self-reported adherence varies significantly according to drug side effects, behavioral factors, and patient’s mood. Careful consideration should be given to the use of self-reported measures of adherence among patients likely to be false-positive adherers.

show abstract

Section: Discussionmentioning

confidence: 99%

“…This scoring approach has been successfully used in previous studies among hypertensive patients. 20, 21 …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Factors associated with false-positive self-reported adherence to antihypertensive drugs

Tedla

Bautista²

2016

J Hum Hypertens

View full text Add to dashboard Cite

show abstract

“…Males are more likely to show low adherence rates, as the youngers, especially in resistant hypertension [23]. Also, the presence of depression and chronic heart disease are associated to lower drug adherence [30].…”

Section: Resultsmentioning

confidence: 99%

“…The unifactorial causality relationship has still a very relevant symbolic presence in most of population: One cause, one disease and one treatment, opposing the current multifactorial approach, that justifies the multiple and different combinations. Another factor in accounting is the drug-related side effects as fatigue, headache, peripheral oedema, cough, allergy, polyuria, erectile and libido dysfunction and metabolic changes, some of them very uncomfortable for patients [23]. many times inefficient are problems relevant to medical adherence.…”

Section: Strategies To Improve Adherence To Medications In Hypertensimentioning

confidence: 99%

Hypertension: Drug Adherence and Social Factors

de¹,

Paulo²

2018

J Hypertens Manag

View full text Add to dashboard Cite

Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension

Reis,

Rocha,

Laranjinha

et al. 2024

FEBS Letters

View full text Add to dashboard Cite

Hypertension is a major contributor to premature death, owing to the associated increased risk of damage to the heart, brain and kidneys. Although hypertension is manageable by medication and lifestyle changes, the risk increases with age. In an increasingly aged society, the incidence of hypertension is escalating, and is expected to increase the prevalence of (cerebro)vascular events and their associated mortality. Adherence to plant‐based diets improves blood pressure and vascular markers in individuals with hypertension. Food flavonoids have an inhibitory effect towards angiotensin‐converting enzyme (ACE1) and although this effect is greatly diminished upon metabolization, their microbial metabolites have been found to improve endothelial nitric oxide synthase (eNOS) activity. Considering the transmembrane location of ACE1 and eNOS, the ability of (poly)phenols to interact with membrane lipids modulate the cell membrane's biophysical properties and impact on nitric oxide (·NO) synthesis and bioavailability, remain poorly studied. Herein, we provide an overview of the current knowledge on the lipid remodeling of endothelial membranes with age, its impact on the cell membrane's biophysical properties and ·NO permeability across the endothelial barrier. We also discuss the potential of (poly)phenols and other plant‐based compounds as key players in hypertension management, and address the caveats and challenges in adopted methodologies.

show abstract

Drug Side Effect Symptoms and Adherence to Antihypertensive Medication

Abstract: Antihypertensive drug side effects was associated with drug adherence but only excessive urination and decrease in sexual drive significantly predicted lower adherence. These symptoms could be used as markers to screen out patients at high risk of non-adherence.

Cited by 116 publications

References 36 publications

Factors associated with false-positive self-reported adherence to antihypertensive drugs

Factors associated with false-positive self-reported adherence to antihypertensive drugs

Hypertension: Drug Adherence and Social Factors

Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension

Contact Info

Product

Resources

About