Drug Shortages: A Complex Health Care Crisis

Fox, Erin R.; Sweet, Burgunda V.; Jensen, Valerie

doi:10.1016/j.mayocp.2013.11.014

Cited by 205 publications

(210 citation statements)

References 30 publications

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“…It has caused serious complications to patients such as prolonging disease course and increasing adverse events including death. [11][12][13] In this case, the use of the alternative to caffeine, aminophylline, resulted in hyponatremia. Preliminary studies have alluded to an association between hyponatremia and adverse long-term neurological outcomes.…”

Section: Discussionmentioning

confidence: 99%

Aminophylline-associated hyponatremia in a premature infant

et al. 2017

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Hyponatremia is common in preterm infants. The causes are usually related to the inability of the premature kidneys to excrete a given water load, excessive sodium losses, or inadequate sodium intake. Here, we present a case of severe hyponatremia in an extreme preterm infant, associated with the use of aminophylline. Aminophylline was administered intravenously on day 1 for the treatment of apnea of prematurity. On day 3, the patient developed hyponatremia which was not responsive to sodium replacement and fluid restriction. Due to concerns of aminophylline-induced hyponatremia, aminophylline was discontinued on day 6, and within 48 h of discontinuation, serum sodium normalized without the need for sodium supplementation. The purpose of the case report is to present a rare complication associated with aminophylline use and to shed light on potential deleterious effects associated with drug shortages.

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Section: Discussionmentioning

confidence: 99%

Aminophylline-associated hyponatremia in a premature infant

et al. 2017

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“…Since 2010, shortages of drugs have been frequent and often of long duration across the medical spectrum and on a global scale. [31][32][33][34][35] Surveys in Europe, [36][37][38] the United States 39 and Canada 40,41 suggest that the problem is persistent and widespread in developed nations. Reports from WHO and the media identify similar problems in many other countries.…”

Section: Do Essential Medicines Lists Reduce Drug Shortages?mentioning

confidence: 99%

The case for an essential medicines list for Canada

Eom

Grootendorst

Duffin

2016

CMAJ

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“…[3] Several studies showed the potential impact of shortages of medications on the patient and health economic burden. [4][5][6] Despite that, still there is shortage of medication at outside and inside Saudi Arabia. [7][8][9] Several studies conducted to measure the actual situation of the pharmacy inventory management system of medications at hospital pharmacies.…”

Section: Introductionmentioning

confidence: 99%