Drug-sensitive Reward in Crayfish: Exploring the Neural Basis of Addiction with Automated Learning Paradigms

Huber, Robert; Imeh-Nathaniel, Adebobola; Nathaniel, Thomas I.; Gore, Sayali V; Datta, Udita; Bhimani, Rohan; Panksepp, Jules B.; Panksepp, Jaak; Staaden, Moira J. van

doi:10.1016/j.beproc.2018.03.015

Cited by 12 publications

(3 citation statements)

References 60 publications

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“…The results suggest that these animals are susceptible to the incentive effect of these drugs of abuse. Moreover, they prefer drug-associated environments and learn to act to obtain their administration ( Søvik and Barron, 2013 ; Zhu et al, 2014 ; Engleman et al, 2016 ; Kaun and Rothenfluh, 2017 ; Huber et al, 2018 ). Thus, the addiction phenomenon seems to be rooted in psycho-neuro-behavioral functions that are very ancient from a phylogenetic perspective and are indeed related to the SEEKING/Exploration emotional disposition.…”

Section: The ML Da-seeking Systemmentioning

confidence: 99%

The SEEKING Drive and Its Fixation: A Neuro-Psycho-Evolutionary Approach to the Pathology of Addiction

Alcaro

Brennan

Conversi

2021

Front. Hum. Neurosci.

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Neuro-ethological studies conducted by Panksepp and his colleagues have provided an understanding of how the activity of the mesolimbic dopaminergic (ML DA) system leads to the emotional disposition to SEEK/Explore, which is involved in all appetitive motivated behavior and mental activity. In pathological addiction phenomena, this emotional disposition “fixes” itself on certain obsessive-compulsive habits, losing its versatility and its natural predisposition to spontaneous and unconditioned activation. Overall, the result is a consistent disinterest in everything that is not the object of addiction. From a neuro-psycho-evolutionary point of view, the predisposition to develop addictive behavior can be attributed to a loss of “functional autonomy” of the SEEKING/Explorative disposition. Indeed, as shown by animal and human studies, the tendency to be conditioned by situations and contexts that provide an immediate reward can be closely related to a deficit in the tonic endogenous activity of the ML DA-SEEKING system.

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Section: The ML Da-seeking Systemmentioning

confidence: 99%

The SEEKING Drive and Its Fixation: A Neuro-Psycho-Evolutionary Approach to the Pathology of Addiction

Alcaro

Brennan

Conversi

2021

Front. Hum. Neurosci.

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“…Thus, locomotor activity was selected to assay for evidence of in vivo behavioral effect. Less directly, recent studies in the crayfish, a related aquatic crustacean, have shown locomotor effects of cocaine, morphine and methamphetamine (Imeh-Nathaniel et al, 2017) and intravenous self-administration of amphetamine (Huber et al, 2018; Huber et al, 2011). This further enhances confidence that behavioral pharmacological effects of recreational drugs can be effectively assessed in the lobster.…”

Section: Introductionmentioning

confidence: 99%

Vapor exposure to Δ9-tetrahydrocannabinol (THC) slows locomotion of the Maine Lobster (Homarus americanus)

Gutierrez

Creehan

Turner

et al. 2021

Preprint

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Rationale: Despite a long history of use in synaptic physiology, the lobster has been a neglected model for behavioral pharmacology. A restauranteur proposed that exposing lobster to cannabis smoke reduces anxiety and pain during the cooking process. It is unknown if lobster gill respiration in air would result in significant Δ9-tetrahydrocannabinol (THC) uptake and whether this would have any detectable behavioral effects. Objective: The primary goal was to determine tissue THC levels in the lobster after exposure to THC vapor. Secondary goals were to determine if THC vapor altered locomotor behavior or nociception. Methods: Tissue samples were collected from muscle, brain and hemolymph of Homarus americanus (N=3 per group) following 30 or 60 minutes of exposure to vapor generated by an e-cigarette device using THC (100 mg/mL in a propylene glycol vehicle). Separate experiments assessed locomotor behavior and hot water nociceptive responses following THC vapor exposure. Results: THC vapor produced duration-related THC levels in all tissues examined. Locomotor activity was decreased (distance, speed, time-mobile) by 30 min inhalation of THC. Lobsters exhibit a temperature-dependent withdrawal response to immersion of tail, antennae or claws in warm water; this is novel evidence of thermal nociception for this species. THC exposure for 60 minutes had only marginal effect on nociception under the conditions assessed. Conclusions: Vapor exposure of lobsters, using an e-cigarette based model, produces dose-dependent THC levels in all tissues and reduces locomotor activity. Hot water nociception is temperature dependent in the lobster, but no clear effects of THC inhalation were confirmed.

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“…Although not highly regarded for their cognitive complexity, crayfish are known to make valuebased decisions by weighing the costs and benefits of different behavioral options, and selecting adaptive behavioral output based on the activation patterns of identifiable neural circuits (Liden, Phillips, & Herberholz, 2010). Below we outline crayfish susceptibility to mammalian drugs of abuse, progressing through unconditioned effects, nonassociative learning, and leading to several associative conditioning processes (Huber et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Crayfish Learning: Addiction and the Ganglionic Brain

Staaden

Huber

2018

Perspect Behav Sci

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Recognizing addiction as a phenomenon with deep evolutionary roots grants valuable new perspectives into understanding its behavioral features, as well as its underlying neural mechanisms and genetic architecture. Although now generally misbranded as "human drugs of abuse," addictive plant alkaloids originally arose as potent chemical defenses against insect herbivory. The products of this evolutionary arms race, compounds such as nicotine, cathinone, or morphine, target essential biological mechanisms for motivation and learning and act as weaponized disruptors. Human vulnerabilities to these addictive drugs may thus represent little more than collateral damage arising from deep homology, i.e., shared biological implementation of behavioral functions with taxa that trace back to the early divergence of bilateral metazoans. Consistent with such a view, invertebrate preparations exhibit a rich spectrum of behavioral and neural consequences in response to drug exposure. Although there is certainly evidence for addiction-like phenomena in many invertebrate lineages, the present review focuses attention primarily on our recent work in crayfish. Using this decapod crustacean model, we have characterized a range of amphetamines, cathinones, and opioids for evidence of unconditioned intoxication, sympathomimetic properties, psychostimulant sensitization, conditioned cue learning, and operant selfadministration. Overall, our findings on drug-sensitive reward in crayfish bear striking similarities to equivalent phenomena illustrated in mammals. Experimentally tractable invertebrate models may thus provide fundamental insights into the homo-and paralogous mechanisms mediating responses to addictive drugs, while illuminating the limits of such contrasts.

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Drug-sensitive Reward in Crayfish: Exploring the Neural Basis of Addiction with Automated Learning Paradigms

Cited by 12 publications

References 60 publications

The SEEKING Drive and Its Fixation: A Neuro-Psycho-Evolutionary Approach to the Pathology of Addiction

The SEEKING Drive and Its Fixation: A Neuro-Psycho-Evolutionary Approach to the Pathology of Addiction

Vapor exposure to Δ9-tetrahydrocannabinol (THC) slows locomotion of the Maine Lobster (Homarus americanus)

Crayfish Learning: Addiction and the Ganglionic Brain

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