Drug Safety: Phenacetin

MACKLIN, A. W.; WELCH, R. M.; CUATRECASAS, P.

doi:10.1126/science.205.4402.144-a

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1980

1982

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“…If phenacetin were tested as a new drug today it would be negative by the standard Ames test. However, there is considerable controversy regarding the possible carcinogenicity of this compound [Cuatrecasas, 1979;Tomatis, 1979;Johansson and…”

Section: Introductionmentioning

confidence: 99%

Use of a rat/hamster S‐9 mixture in the ames mutagenicity assay

1981

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Based on the findings of Nagao et al [1978] that phenacetin is negative in the standard Ames test with Aroclor induced rat S-9 and positive with hamster S-9, the test was performed with a mixture of rat/hamster S-9. Phenacetin was mutagenic with the mixture. The activity of the mixture was compared to the rat S-9 alone with low concentrations of 2-aminoanthracene (a strong promutagen for Salmonella typhimurium TA 1535, TA 100, TA 1537, and TA 98), nitrosopiperidine (a weak promutagen), and 1,2 epoxybutane (a weak, direct-acting mutagen). Except for an increased mutagenic activation by the mixture with nitrosopiperidine the mixture was comparable to the rat S-9 alone, indicating that replacing rat S-9 with a rat/hamster S9 mixture in the standard Ames test could increase the sensitivity of the test without interfering with rat S-9 activity.

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Section: Introductionmentioning

confidence: 99%