Drug retention and distribution after intratumoral chemotherapy with fluorouracil/epinephrine injectable gel in human pancreatic cancer xenografts

Smith, Jill P.; Kanekal, Sarathchandra; Patawaran, Montesa; Chen, Joy Y.; Jones, Richard E.; Orenberg, Elaine K.; Yu, Ning

doi:10.1007/s002800050977

Cited by 25 publications

(14 citation statements)

References 17 publications

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“…The IT drug concentration was 9× higher using the IT gel vs. the IT drug solution. Even more interesting was the fact that IT injection of the drug solution resulted in 29× more drug in the tumor tissue compared to systemic drug delivery [70].…”

Section: Methods For Prolonging High Intratumoral Drug Concentrationmentioning

confidence: 99%

Bronchoscopic intratumoral chemotherapy of lung cancer

2008

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Section: Methods For Prolonging High Intratumoral Drug Concentrationmentioning

confidence: 99%

Bronchoscopic intratumoral chemotherapy of lung cancer

2008

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“…Because of its biological properties and easy availability, it is widely used as a bio-material [2,3]. Collagen processing involves liquid aqueous preparations as injectables for tissue augmentation [4] or as drug carriers for tumor treatment [5] and tissue regeneration [6]. In many of these applications, the self assembly of collagen aggregation and organization of individual molecules play an important role.…”

Section: Introductionmentioning

confidence: 99%

Degree of crosslinking of collagen at interfaces: Adhesion and shear rheological indicators

Fathima

Dhathathreyan

Ramasami³

et al. 2011

International Journal of Biological Macromolecules

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“…Doxorubicin was most potent but all intratumoral systems reduced tumour burden by " 70% . In more recent research with¯uorouracil} epinephrine gel (Smith et al 1999), it was again shown that much higher concentrations were achieved in tumours for intratumoral gel injections (18.4 mm ) compared with¯uorouracil solutions given intravenously (2.02 mm ) or intraperitoneally (0.07 mm ). Ravichandran et al (1998) also showed the bene® t of intratumoral delivery of lithium linolenate for the treatment of pancreatic carcinoma in a nude mouse model.…”

Section: Animal Intratumoral Chemotherapy Studiesmentioning

confidence: 99%

Intratumoral cancer chemotherapy and immunotherapy: opportunities for nonsystemic preoperative drug delivery

Goldberg

Hadba

Almond

et al. 2002

Journal of Pharmacy and Pharmacology

175

143

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The recent literature documents the growing interest in local intratumoral chemotherapy as well as systemic preoperative chemotherapy with evidence for improved outcomes using these therapeutic modalities. Nevertheless, with few exceptions, the conventional wisdom and standard of care for clinical and surgical oncology remains surgery followed by radiation and/or systemic chemotherapy, as deemed appropriate based on clinical ndings. This, in spite of the fact that the toxicity of conventional systemic chemotherapy and immunotherapy affords limited effectiveness and frequently compromises the quality of life for patients. Indeed, with systemic chemotherapy, the oncologist (and the patient) often walks a ne line between attempting tumour remission with prolonged survival and damaging the patient's vital functions to the point of death. In this context, it has probably been obvious for more than 100 years, due in part to the pioneering work of Ehrlich (1878), that targeted or localized drug delivery should be a major goal of chemotherapy. However, there is still only limited clinical use of nonsystemic intratumoral chemotherapy for even those high mortality cancers which are characterized by well de ned primary lesions i.e. breast, colorectal, lung, prostate, and skin.There has been a proliferation of intratumoral chemotherapy and immunotherapy research during the past two to three years. It is therefore the objective of this review to focus much more attention upon intratumoral therapeutic concepts which could limit adverse systemic events and which might combine clinically feasible methods for localized preoperative chemotherapy and/or immunotherapy with surgery. Since our review of intratumoral chemo- Given the state-of-the-art in clinical and surgical oncology, and the advances that have been made in intratumoral drug delivery, minimally invasive tumour access i.e. ne needle biopsy, new drugs and drug delivery systems, and preoperative chemotherapy, it is timely to present a review of studies which may suggest future opportunities for safer, more effective, and clinically practical non-systemic therapy. General perspective for traditional systemic therapiesThe toxicity of conventional systemic cancer chemotherapy and immunotherapy has severely limited the safety and eOE ectiveness of such therapy. The quality of life

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Drug retention and distribution after intratumoral chemotherapy with fluorouracil/epinephrine injectable gel in human pancreatic cancer xenografts

Cited by 25 publications

References 17 publications

Bronchoscopic intratumoral chemotherapy of lung cancer

Bronchoscopic intratumoral chemotherapy of lung cancer

Degree of crosslinking of collagen at interfaces: Adhesion and shear rheological indicators

Intratumoral cancer chemotherapy and immunotherapy: opportunities for nonsystemic preoperative drug delivery

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