Drug resistant Skeletal Tuberculosis in a tertiary care centre in South India

Abstract

The prevalence of Multi-drug resistant tuberculosis patients in our centre was 3.7% and that of Extremely drug resistant tuberculosis cases was 0.4%. A Multi-disciplinary approach with drug susceptibility tests, sensitive drugs, and surgery if required is essential. Health education is essential to improve awareness among health care professionals about the danger of drug resistance in tuberculosis.

Analysis of drug resistance and mutation profiles in Mycobacterium tuberculosis isolates in a surveillance site in Beijing, China

“… 1 Despite the development of newer drugs to combat this disease, drug resistance has emerged as a major concern. 2 Although the average time to treat patients with fully susceptible TB is 6 to 9 months, the treatment of drug-resistant TB may require 12 to 18 months or even longer, and the drugs are more expensive but less effective. In 2019, close to half a million people globally developed rifampicin (RIF)-resistant TB, of whom 78% had multidrug-resistant TB (MDR-TB).…”

Clinical features, resistance patterns and treatment outcomes of drug-resistant extra-pulmonary tuberculosis: A scoping review

“…Of these, 10 were excluded because drug resistance was not separately reported for extra-pulmonary sites (10/13) [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] . Finally, 15 records were included in this review [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] . Fig.…”

Pediatric Multidrug-Resistant Disseminated Tuberculosis Presenting as Small Finger Tuberculous Osteomyelitis

“…In 2020, the World Health Organization reported 71% of adults with pulmonary TB were monoresistant and a 3% to 4% incidence of MDR-TB in both children and adults 9,24 . Specific to TB osteomyelitis, MDR is reported at 3.7% to 12.7% 25,26 .…”