Drug-resistant gram-negative uropathogens: A review

Khoshnood, Saeed; Heidary, Mohsen; Mirnejad, Reza; Bahramian, Aghil; Sedighi, Mansour; Mirzaei, Habibollah

doi:10.1016/j.biopha.2017.08.006

Cited by 64 publications

(63 citation statements)

References 109 publications

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“…It has been described that in up to 96% of cases, antibiotics that are not indicated for UTIs in pregnant women are being prescribed [22]. Errors in antibiotic prescriptions for these types of infections is a crucial issue, considering that UTIs are one of the most common causes of doctor visits at the primary care level, affecting approximately 150 million individuals annually worldwide [23]. In the United States, these cases are the cause for 0.7% of all outpatient visits.…”

Section: Discussionmentioning

confidence: 99%

Knowledge regarding antibiotic use among students of three medical schools in Medellin, Colombia: a cross-sectional study

et al. 2020

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Background: The objective of the present study was to describe the knowledge regarding the antibiotic therapy of students of three medical schools in Medellín, Colombia. Methods: The study population comprised medical students who were enrolled in three universities. The instrument contained questions regarding their current academic term, the university, the perceived quality of the education received on antibiotic therapy and bacterial resistance, and specific questions on upper respiratory tract infections, pneumonia, urinary tract infections, and skin and soft tissue infections. The information was analyzed by calculating frequencies and measures of dispersion and central tendency. Knowledge regarding the treatment for each type of infection was compared using the Mann-Whitney U test and the Kruskal-Wallis H test. Results: We included 536 medical students, of which 43.5% students consider that the university has not sufficiently trained them to interpret antibiograms and 29.6% students consider that the quality of information received on the subject at their university ranges from regular to poor. The mean score for knowledge regarding antibiotic therapy for upper respiratory tract infections was 44.2 (9.9) on a scale from 0 to 100. The median score with regard to the treatment of pneumonia was 52.9 (14.7), that of urinary tract infection was 58.7 (14.8), and that of skin and soft tissue infections was 63.1 (19.4). The knowledge regarding antibiotic therapy for upper respiratory tract infections, pneumonia, and urinary tract infection does not improve with the academic term, the university, or perceived quality of the education received. Conclusion: A large proportion of medical students perceive that the training received from the university is insufficient with regard to antibiotic use and bacterial resistance, which is consistent with the limited knowledge reflected in the selection of antibiotic treatment for respiratory, urinary tract, and skin and soft tissue infections. Overall, the situation was identical among all universities, and it did not significantly increase with the completion of an academic term.

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Section: Discussionmentioning

confidence: 99%

Knowledge regarding antibiotic use among students of three medical schools in Medellin, Colombia: a cross-sectional study

et al. 2020

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“…It has been described that in up to 96% of cases antibiotics are prescribed for UTIs in pregnant women without them being indicated [22]. Errors in the prescription of antibiotics for these types of infections is an important topic given that UTIs are one of the most common causes of doctor visits at the primary care level, affecting nearly 150 million people per year worldwide [23]. In the USA these cases are to blame for 0.7% of all outpatient visits.…”

Section: Discussionmentioning

confidence: 99%

Knowledge regarding antibiotic use among medical students, Medellin, Colombia: A cross-sectional study

Higuita-Gutiérrez¹,

Molina²,

Acevedo³

et al. 2019

Preprint

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“…INVALID CITATION !!! , ;Foxman, 2003, Epidemiology of urinary tract infections: Incidence`, morbidity`, and economic costs} Approximately 150 million people are diagnosed with UTI each year worldwide [3]. UTI, which can cause shock and death, ranks third among all diseases that die from infection [4].…”

Section: Introductionmentioning

confidence: 99%

“…Enterobacteriaceae, is the common cause of both community-acquired and hospital acquired UTIs [3,5]. Many Chinese medicines that have a heat-clearing and detoxicating function have been proved to have the bacteriostasis on pathogenic microorganisms, which can inhibit or destroy the formation of toxic substances [6,7].…”

Section: Introductionmentioning

confidence: 99%

Sanjin Tablets for Acute Uncomplicated Lower Urinary Tract Infection (Syndrome of Dampness-Heat in the Lower Jiao): Protocol for Randomized, Double-Blind, Double Dummy, Parallel Control of Positive Drug, Multicentre Clinical Trial

Lyu

Xie

Gao

et al. 2019

Preprint

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Background Acute uncomplicated lower urinary tract infection (UTI) is one of the most common bacterial infections. Patients usually present with dysuria, urinary urgency, urinary frequency and suprapubic pain or tenderness. Approximately 150 million people are diagnosed with UTI each year worldwide. The high recurrence rate of lower UTI is a common problem of clinical treatment. The misuse of antibiotics has led to the emergence of a number of resistant bacterial strains. Thus, traditional Chinese medicine is considered as an alternative option for treating acute uncomplicated lower UTI. Thus, this study aims to evaluate the efficacy, safety and recurrence rate of Sanjin tablets (SJT) for the treatment of acute uncomplicated lower UTI; explore whether SJT can reduce or substitute the use of antibiotics in the treatment of acute uncomplicated lower UTI. Methods/Design In this study, a randomized, double blind, double dummy, parallel control of positive drug, multicentre clinical study will be established. A total of 252 patients with acute uncomplicated lower UTI (syndrome of dampness-heat in the lower jiao) will be randomly allocated in the ratio of 1:1:1 to three groups: experimental group, control group 1 and control group 2. The experimental group receives Sanjin tablets plus levofloxacin tablets (LT) placebo; the control group 1 receives LT plus SJT placebo; and the control group 2 receives SJT plus LT on the first 5 days, SJT plus LT placebo on the last 2 days. Each group will be treated for 7 days and followed-up for 1-2 times. The primary outcome measures of effective rate and recurrence rate are symptoms. Secondary outcome measures of effective rate and recurrence rate are the urine leukocyte, bacteriology examination and safety assessment. Outcomes will be assessed at baseline and after treatment. Discussion This study protocol will provide the research data of efficacy, safety and recurrence rate of SJT for the treatment of acute uncomplicated lower UTI; explore the possibility of using SJT to reduce or substitute the use of antibiotics. The results of this study will improve the rational use of drugs, especially the rational application of antibiotics. It will also enable safety evaluation from laboratory indices and adverse events, which will provide reliable evidence for clinical treatment.

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Drug-resistant gram-negative uropathogens: A review

Cited by 64 publications

References 109 publications

Knowledge regarding antibiotic use among students of three medical schools in Medellin, Colombia: a cross-sectional study

Knowledge regarding antibiotic use among students of three medical schools in Medellin, Colombia: a cross-sectional study

Knowledge regarding antibiotic use among medical students, Medellin, Colombia: A cross-sectional study

Sanjin Tablets for Acute Uncomplicated Lower Urinary Tract Infection (Syndrome of Dampness-Heat in the Lower Jiao): Protocol for Randomized, Double-Blind, Double Dummy, Parallel Control of Positive Drug, Multicentre Clinical Trial

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