Drug resistance reversal by combretastatin-A4 phosphate loaded with doxorubicin in polymersomes independent of angiogenesis effect

Zhu, Jinfang; Hu, Mengying; Qiu, Liyan

doi:10.1111/jphp.12725

Cited by 8 publications

(9 citation statements)

References 47 publications

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“…The strictly controlled drug releases, which exert different mechanisms of action, might be most beneficial in terms of achieving a synergistic effect by different drugs. To date, it is known that CA-4P may sensitize drug-resistant human breast cancer MCF-7/ADR cells to DOX [135]. Additionally, Zhu et al showed that the polymersomes dual loaded with CA-4P and DOX could inhibit Pgp function by downregulating protein kinase C alpha (PKCα), stimulating ATPase activity, decrease ATP level and increase the generation of ROS, thus overcoming DOX resistance [135].…”

Section: Modifications Of the Hydroxyl Group Of Combretastatin Corementioning

confidence: 99%

More Than Resveratrol: New Insights into Stilbene-Based Compounds

et al. 2020

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The concept of a scaffold concerns many aspects at different steps on the drug development path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point for the design of the structure dedicated to specific molecular targets. For many years, the chemical uniqueness of the stilbene structure has inspired scientists from different fields such as chemistry, biology, pharmacy, and medicine. In this review, we present the outstanding potential of the stilbene-based derivatives. Naturally occurring stilbenes, together with powerful synthetic chemistry possibilities, may offer an excellent approach for discovering new structures and identifying their therapeutic targets. With the development of scientific tools, sophisticated equipment, and a better understanding of the disease pathogenesis at the molecular level, the stilbene scaffold has moved innovation in science. This paper mainly focuses on the stilbene-based compounds beyond resveratrol, which are particularly attractive due to their biological activity. Given the “fresh outlook” about different stilbene-based compounds starting from stilbenoids with particular regard to isorhapontigenin and methoxy- and hydroxyl- analogues, the update about the combretastatins, and the very often overlooked and underestimated benzanilide analogues, we present a new story about this remarkable structure.

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Section: Modifications Of the Hydroxyl Group Of Combretastatin Corementioning

confidence: 99%

More Than Resveratrol: New Insights into Stilbene-Based Compounds

et al. 2020

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“…Tetraethyl silicate (TEOS), triethanolamine (TEA), 5,10,15,20-tetraphenylporphyrin (TPP), (5,10,15,20)tetra(4-aminophenyl)porphyrin (NH 2 -TPP), dextran and doxorubicin hydrochloride (DOX•HCl) were all purchased from Shanghai Aladdin Biochemical Technology Co., Ltd. 3-Aminopropyltrimethoxysilane (APS) was purchased from Braunwell Chemical Technology Co., Ltd. CA4P was acquired from Solarbio Science & Technology Co., Ltd. Cetyltrimethylammonium chloride (CTAC) was purchased from Sigma-Aldrich Co., Ltd. Dulbecco's modi ed Eagle's medium (DMEM), memorial institute medium (RPMI)-1640, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), 4',6-diamidino-2-phenylindole (DAPI), 1,3-diphenylisobenzofuran (DPBF), 2',7'-dichlorodihydro uorescein diacetate (DCFH-DA), live/dead cell viability/toxicity kit, and Annexin V-FITC/PI staining kit were all purchased from Vicmed (Xuzhou, China). Caspase 3 polyclonal antibody (caspase 3 PAb) was purchased from Proteintech Co. (USA).…”

Section: Chemical and Reagentsmentioning

confidence: 99%

“…CA4P is one of novel angiogenesis inhibitors, which can induce apoptosis by binding tubulin dimers and preventing microtubule polymerization. It's reported that CA4P has the potential to sensitize drug-resistant MCF-7/ADR cells to DOX due to the inhibition of angiogenesis [10]. Anti-angiogenesis combined with anticell proliferation has become a novel tumor therapy strategy, which was referred as "A + strategy" [11].…”

Section: Introductionmentioning

confidence: 99%

Sequential Drug Delivery By Injectable Macroporous Hydrogels For Combined Photodynamic-Chemotherapy

Zhong

Zhang

Sun³

et al. 2021

Preprint

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With hollow mesoporous silica (hMSN) and injectable macroporous hydrogel (Gel) used as the internal and external drug-loading material respectively, a sequential drug delivery system DOX-CA4P@Gel was constructed, in which combretastatin A4 phosphate (CA4P) and doxorubicin (DOX) were both loaded. The anti-angiogenic drug, CA4P was initially released due to the degradation of Gel, followed by the anti-cell proliferative drug, DOX, released from hMSN in tumor microenvironment. Results showed that CA4P was mainly released at the early stage. At 48 h, CA4P release reached 71.08%, while DOX was only 14.39%. At 144 h, CA4P was 78.20%, while DOX release significantly increased to 61.60%, showing an obvious sequential release behavior. Photodynamic properties of porphyrin endow hydrogel (φΔ(Gel)=0.91) with enhanced tumor therapy effect. In vitro and in vivo experiments showed that dual drugs treated groups have better tumor inhibition than solo drug under near infrared laser irradiation, indicating the effectivity of combined photodynamic-chemotherapy.

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“…48 Recently, an indirect effect of inhibition of P-glycoprotein function has been suggested. 49 The experiments involved the construction of methoxy poly(ethylene glycol)-b-poly lactic acid (mPEG-b-PLA) co-polymer nano-vesicles as drug carriers. These nanoparticles were loaded with combretastatin or doxorubicin as single agents or in combination.…”

Section: Molecular Configuration and Antitumour Efficacy Of Analoguesmentioning

confidence: 99%

Combretastatin analogues in cancer biology: A prospective view

Sherbet

2019

J of Cellular Biochemistry

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Drug resistance reversal by combretastatin-A4 phosphate loaded with doxorubicin in polymersomes independent of angiogenesis effect

Abstract: The findings validated the sensitization property of CA4P on DOX independent of its well-known angiogenesis effect, which would provide a novel and promising strategy for drug-resistant cancer therapy.

Cited by 8 publications

References 47 publications

More Than Resveratrol: New Insights into Stilbene-Based Compounds

More Than Resveratrol: New Insights into Stilbene-Based Compounds

Sequential Drug Delivery By Injectable Macroporous Hydrogels For Combined Photodynamic-Chemotherapy

Combretastatin analogues in cancer biology: A prospective view

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