Drug Resistance Patterns of Mycobacterium Tuberculosis – Isolates from Indore, India

Songara, Prafulla; Deva, Rupal; Bajpai, Ila Srivastava; Nema, Sushma; Kothari, Vinita

doi:10.9734/bjmmr/2015/18992

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“…We tested serum from clinical suspects were initially to screen them for tuberculosis infection by IGRA method. We tested the samples in our lab for detection of causative agent using the method developed by us as described earlier [21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Study Settingsmentioning

confidence: 99%

“…The first-line treatment anti-TB drugs may result in further spread of MDR bacteria in the Population [19]. Earlier, we had reported utilization of modern molecular biology methods in conjugation with classical methods for identification of M. tuberculosis infection to assist with the judgment for prescription of right therapy for the Mycobacterium infected individual [20], The prevalence of pulmonary tuberculosis in district Jabalpur were also reported [21]. Since the modern molecular biological methods are still very expensive for the patients, in India.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Latent TB Detection and Isolation of MDR TB Bacteria in, MP, India

Bajpai¹,

Monika²,

Gaur³

et al. 2015

Clin Microbiol

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Aim: Tuberculosis which is an infectious disease caused by M. tuberculosis causing pulmonary and extra pulmonary tuberculosis in clinical suspects in Indore and region around central state of India by IGRA methods. In India, TB which is declared to be 'notifiable disease of the nation' by the RNTCP since 2012. We wanted to analyze present state of existence of the same in our city Indore and region around. We wanted to study the present strata of IGRA detected in population of Indore in MP correlating with the Mycobacterium isolates in our laboratory, though the protocol of DOTS have been followed in the country. Experimental design:In present study, we tested clinical suspects using microbiology biology cultivation method and ELISA method for IGRA in Indore for Mycobacterium tuberculosis in the clinical suspects in our Indore lab, MP, India. Place and duration:The study was one in Central lab-Oncquest India Ltd. in Indore between period 2012 to 2014.Methodologies: The present study included 135 patients, including 49 male, and 86 female patients. We used developed TB-TMA method (Oncquest, Ltd.) to detect infection of clinical suspects and utilized culture susceptibility test to detect drug resistance in infecting Mycobacterium causing tuberculosis, tested at Central lab-Oncquest ltd. in India using microbiological methods. The method of drug resistance in Mycobacteria was performed using microbiology methods of drug resistance as described by Songara P, 2015. Results:We found 53% samples to be positive from male group compared to 29% from female group of patients. We could isolate Mycobacterium sp from various clinical suspects using basic microbiology and cultivation methods. Were found 41.6% Mycobacterium to be sensitive to sensitive to INH 36.65 to RIF, 23.3 to PYRA, 305 to ETHM, 25% to STREPTO isolated from various samples from clinical suspects. Conclusion:We were able to detect M. tuberculosis and determine their drug resistance in Mycobacterium method by MDR sure method.

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