Drug Resistance in Malaria

Hallinan, T. C.

doi:10.1136/bmj.2.4828.135

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2017

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“…However, although combination therapies have now been adopted, resistance against many existing antimalarials has been observed since the 1950s (Bishop, 1951 ; Hallinan, 1953 ; Sandosham et al 1964 ) and remains a severe threat (Rieckmann & Cheng, 2002 ; Chinappi et al 2010 ; Dondorp et al 2010 b ; Newton et al 2016 ; Parija, 2016 ; Menard & Dondorp, 2017 ; Zhou et al 2017 ). This bleak view of the future of available anti-malarial chemotherapeutics makes it imperative to invest more efforts in identifying new potent chemotypes that will offer both efficacy and safety.…”

Section: Introductionmentioning

confidence: 99%

Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis

Mina

Denny

2017

Parasitology

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