Drug Repurposing in Cancer

Shruthi, N. R.; Jain, Munendra; Ganesan, Harsha; Banerjee, Antara; Zhang, Hong; X, Sun; Pathak, Surajit

doi:10.1007/978-981-19-5399-6_8

Cited by 1 publication

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References 67 publications

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“…Repurposing of drugs has now become a strategy to treat several cancers [133]. Lung cancer is among the most unpredictable of cancers throughout the world, and the progression of the disease is very uncertain.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment

Girigoswami

2023

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Lung cancer is managed using conventional therapies, including chemotherapy, radiation therapy, or a combination of both. Each of these therapies has its own limitations, such as the indiscriminate killing of normal as well as cancer cells, the solubility of the chemotherapeutic drugs, rapid clearance of the drugs from circulation before reaching the tumor site, the resistance of cancer cells to radiation, and over-sensitization of normal cells to radiation. Other treatment modalities include gene therapy, immunological checkpoint inhibitors, drug repurposing, and in situ cryo-immune engineering (ICIE) strategy. Nanotechnology has come to the rescue to overcome many shortfalls of conventional therapies. Some of the nano-formulated chemotherapeutic drugs, as well as nanoparticles and nanostructures with surface modifications, have been used for effective cancer cell killing and radio sensitization, respectively. Nano-enabled drug delivery systems act as cargo to deliver the sensitizer molecules specifically to the tumor cells, thereby enabling the radiation therapy to be more effective. In this review, we have discussed the different conventional chemotherapies and radiation therapies used for inhibiting lung cancer. We have also discussed the improvement in chemotherapy and radiation sensitization using nanoparticles.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment

Girigoswami

2023

Genes

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Drug Repurposing in Cancer

Cited by 1 publication

References 67 publications

Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment

Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment

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