Drug-releasing textiles

Smart polymers for cell therapy and precision medicine

“…Due to the hydrophobic interaction, Pluronics self-assemble in the aqueous solution, and the micellization conditions of Pluronics are dominated by both concentration and temperature [53, 54]. The hydrophobic segments of Pluronic aggregate in order to minimize surface tension when concentration is higher the critical micelle concentration (CMC) and the temperature is lower critical solution temperature (LCST) [55, 56]. The amphiphilic polymers also show some weaknesses such as rapid dissolution, short residence time, and weak mechanical strength [57].…”

Funcionalização de substrato têxtil com partículas poliméricas carregadas com repelente visando proteção contra o mosquito Aedes aegypti

“…Enquanto o reservatório estiver saturado, um gradiente de concentração constante do fármaco é mantido através da membrana e a liberação é alcançada a uma taxa constante, liberação de ordem zero. A liberação do medicamento de ordem zero pode manter a concentração do medicamento dentro do intervalo terapêutico por períodos prolongados e minimizar episódios de sub exposição ou toxicidade (SHAH, HALACHEVA, 2016). Quando a concentração do medicamento cai abaixo do nível de saturação, o gradiente de concentração e a taxa de liberação do medicamento diminuem.…”

Cellulose based aerogel microfibers for biomedical applications

“…Also, extended exposure to organic solvents during the spinning and regeneration might in wet spinning negatively impact the fi ber biocompatibility, but it is applicable to many natural based polymers and benefi t from mild temperature processing conditions. Although electrospinning is a simple, inexpensive technique resulting in submicron fi bers, the toxicity of the solvents and the instability of the jets, and the processing issues with conductive polymers can be highly challenging [141,174].…”

“…On the other hand, nonwoven fabrics such as electrospun fi bers with smaller pore sizes are more feasible to reach nanostructures with sophisticated morphologies. Nevertheless, considerable challenges must be solved to scale up the fabrication procedure and transform electrospinning into a commercial and operational process [141,174]. For instance, the poor reproducibility, high dependency of processing conditions on polymer-solution nature, and limitation of the obtainable mesh thickness are the main challenges in the aspect of the mass production of nanofi ber fabrics [205].…”

“…Using this loading method, the drug is incorporated on the surface of the fi ber by immersing it in a drug solution [213] or by coating it with drug encapsulated micro-or nanoparticles [225] (Figure 1.7A). Several coating methods, such as electrochemical deposition [226,227], immersion [212], dispersion, and curtain coating [174] are used for drug incorporation onto the fi bers. Coating parameters such as pH, solids content, and coating thickness can be tuned to reach the desired coating [174].…”