Drug-releasing textile materials: current developments and future perspectives

Mehata, Abhishesh Kumar; Deepa, D; Vikas, .; Priya, Vishnu; Muthu, Madaswamy S

doi:10.1016/b978-0-323-96117-2.00001-7

Cited by 2 publications

(1 citation statement)

References 142 publications

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“…The decrease in particle size may also increase the rate of absorption in some cases [13]. Amorphization of the drug: Conversion of the crystalline drug into its amorphous form increases the solubility, changing the crystal lattice's range order [14,15]. Increase in wettability of the drug: This increases the area of contact between the solvent and the drug thereby increasing the solubility [16].…”

Section: Introductionmentioning

confidence: 99%

Design, Optimization, and Characterization of a Novel Amorphous Solid Dispersion Formulation for Enhancement of Solubility and Dissolution of Ticagrelor

et al. 2023

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Objective: The study aims to enhance the solubility and dissolution of ticagrelor by formulating an amorphous solid dispersion using the hot melt extrusion technique. Methods: Solubility of ticagrelor is very limited in water and buffers of pH 1.2 to 6.8, which is one of the prime reasons for its low oral bioavailability. Amorphous solid dispersions were prepared using the Hot Melt Extrusion technique using different polymers, plasticizers, and surfactants. The formulation is optimized based on the level of polymer in the formulation. The final formulation of Ticagrelor Amorphous Solid Dispersion is made with a drug-polymer ratio of 1:3, keeping the plasticizer level at 10% of the polymer along with a surfactant Sodium Lauryl Sulfate. Results: The formulation showed an increase in solubility of 193.95-times in water, 50.71-times in 0.1 N HCl, 332.74-times in pH 4.5 acetate buffer, and 85.20-times in pH 6.8 phosphate buffer as compared to the pure drug. The drug release of the final formulation was found to be 70.0±4.4%, 55.4±1.1%, 35.5±2.1%, and 30.0±0.8% at 90 min, while the reference product showed a release of 9.4±1.1%, 20.7±0.5%, 8.4±0.3%, and 7.8±0.2% at 90 min in water, 0.1 N HCl, pH 4.5 acetate buffer and pH 6.8 Phosphate Buffer respectively. The drug release of the final formulation was found to be 99.1±3.8% at 60 min in 0.2% w/v Polysorbate-80 in water. Conclusion: In the present study, the amorphous solid dispersion of the poorly-soluble drug ticagrelor was successfully prepared. The polymer, Plasdone S630, is considered the most suitable with ticagrelor for formulating amorphous solid dispersion using Hot Melt Extrusion technology to increase the solubility and dissolution of the drug.

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Section: Introductionmentioning

confidence: 99%

Design, Optimization, and Characterization of a Novel Amorphous Solid Dispersion Formulation for Enhancement of Solubility and Dissolution of Ticagrelor

et al. 2023

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Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

C. Gouveia,

Mouro

2024

Electrospinning - Theory, Applications, and Update Challenges

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Electrospinning, a remarkable and versatile technique has been related to medical textiles, aiming to produce nanomaterials for drug delivery and tissue regeneration applications. Furthermore, electrospun nanofibrous materials with unique properties as favorable pore size distribution, porosity, surface area, and wettability, along with effective mechanical properties, are the frontrunner solutions. Also, the features of the nanofibrous structures can be designed and optimized by controlling electrospinning parameters related to the solution properties, the setup parameters, and the environmental conditions to design nanofibrous textile materials for the desired applications. Further, to accomplish the required functionality of the drug-delivery systems, a rather broad range of drugs have been loaded into the nanofibers using different electrospinning techniques, namely the blending, side-by-side, coaxial, tri-axial, emulsion, and multi-needle electrospinning, in order to accomplish specific drug-release profiles of the designed nanofibrous textiles. Thus, this chapter describes the different electrospinning techniques that have been utilized in the production of the textile nanofibrous materials as the application of these materials in bone, nerve, periodontal, and vascular regeneration, as well as in wound dressings, personal-protective-equipment (PPE), and cancer treatment, providing an overview of the recent studies and highlighting the current challenges and future perspectives for their medical applications.

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Drug-releasing textile materials: current developments and future perspectives

Cited by 2 publications

References 142 publications

Design, Optimization, and Characterization of a Novel Amorphous Solid Dispersion Formulation for Enhancement of Solubility and Dissolution of Ticagrelor

Design, Optimization, and Characterization of a Novel Amorphous Solid Dispersion Formulation for Enhancement of Solubility and Dissolution of Ticagrelor

Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

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