Drug release profile in core–shell nanofibrous structures: A study on Peppas equation and artificial neural network modeling

Core–shell designed scaffolds for drug delivery and tissue engineering

“…Results showed that the protein incorporated in the core presented much slower release compared to that in the shell and that the release could be tailored depending on the amount of nanopowders incorporated [31]. Using electrospun nanofibers, a similar work was also conducted, where a more sustained release of protein molecules was observed when incorporated in the core [110]. Another interesting study was also performed, where the VEGF was loaded in the inner part of the membrane while PDGF was loaded in the outer part [111].…”

Dipyridamole embedded in Polycaprolactone fibers prepared by coaxial electrospinning as a novel drug delivery system

“…Therefore, the release kinetics of DIP were analyzed using the mathematical model of Peppas [20], which has been widely used for the investigation of the release kinetics of pharmaceutical agents from polymeric scaffolds prepared by PCL [16,23,24].…”

Study of the release kinetics of (−) epicatechin: Effect of its location within the fiber or sphere

“…One application of this type of materials is in the encapsulation of biologically active molecules and drugs for tissue engineering, 25 that is, in patches. [34][35][36][37] According to the release mechanism of the drug, there are different release percentages and time to reach equilibrium; these parameters must be related to the required dose for each type of drug. [34][35][36][37] According to the release mechanism of the drug, there are different release percentages and time to reach equilibrium; these parameters must be related to the required dose for each type of drug.…”