Drug release of yolk/shell microcapsule controlled by pH-responsive yolk swelling

Jia, Jiru; Wang, Chaoxia; Chen, Kunlin; Yin, Yunjie

doi:10.1016/j.cej.2017.06.170

Cited by 36 publications

(38 citation statements)

References 45 publications

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“…The PDS swelling ratios increased from 10.7 to 5.8 at pH in the range of 5.5-3.4. The release amounts of ibuprofen were 44% (pH = 3.4) and 72% (pH = 5.3) after 6 hr, which higher than those of pH = 7.5 (10%) (Jia et al, 2017); it provides an effective pathway for drug delivery. Polk et al constructed a polymer albumin-loaded delivery system with the sustained-release property and found that the pH value of extracapsular solution had a significant effect on the release of albumin (Polk et al, 1994a).…”

Section: Ph Valuesmentioning

confidence: 86%

“…Good strength and stability (Jia, Wang, Chen, & Yin, 2017) Semisynthetic polymers Biodegradable Hydrophobic Cellulose derivatives: sodium hydroxymethyl cellulose, ethyl cellulose, cellulose acetate, and its esters, etc.…”

Section: Natural Polymersmentioning

confidence: 99%

“…The dramatic softening of the microcapsules at higher pH values led to reduction in the charge density of polycations and the number of ionic cross-links (Lulevich & Vinogradova, 2004). Jia et al synthesized the pH-sensitive microcapsules by using poly (DEAEMA-styrene) (PDS) and polystyrene as core and shell, respectively and then loaded ibuprofen (Jia et al, 2017). This yolk/shell capsules with a size of 500 nm displayed a nonswelling morphology at low pH values to avoid extra drug release ( Table 1).…”

Section: Ph Valuesmentioning

confidence: 99%

“…(Prata, Frascareli, Silva, & Hubinger, n.d.;Díaz et al, 2015;Sun & Zhang, 2002;Xie et al, 2010) pH values Stability, permeability, structural formation, charge density, release, etc. (Huguet & Dellacherie, 1996;Jia et al, 2017;Lulevich & Vinogradova, 2004;Polk, Amsden, De Yao, Peng, & Goosen, 1994a) Temperatures Release, activity and morphology (Cui, Zhang, Lin, Li, & Jin, 2008;Dianawati, Lim, Ooi, & Shah, 2017;Kuck, Wesolowsk, & Norena, 2017;Kohler, Biesheuvel, Weinkamer, Mohwald, & Sukhorukov, 2006;Kohler, Shchukin, Mohwald, & Sukhorukov, 2005;Liu et al, 2008;Ye, Wang, Liu, & Tong, 2005) Particle sizes Loading, aggregation, drug release and retention (Berkland, King, Cox, Kim, & Pack, 2002;Foda & El, 1989;Lemos et al, 2017;Morris & Warburton, 1984;Sen, Bahadur, Mazumder, & Bhattacharya, 2012) Additives and others Strength, release, yield, encapsulation efficiency, membrane porosity, etc. (Angelova & Hunkeler, 2001;Bartkowiak, 2002;Fang, Li, & Liu, 2010;Jono et al, 1997;Luzzi & Gerraughty, 1967;Simón, Rodriguez, & Sanchez, 2013;Varma, Kaushal, Garg, & Garg, 2004;Wang, Hu, Liu, He, & Guo, 2011;Wong et al, 2015;Yamaguchi et al, 2002) F I G U R E 4 Schematic diagram of chitosan and sodium alginate polyelectrolyte membrane formation (Liu et al, 2008) (Cui et al, 2008).…”

Section: Factors Effects Referencesmentioning

confidence: 99%

See 3 more Smart Citations

Recent progress in preparation and agricultural application of microcapsules

Teng

Mao

et al. 2019

J Biomedical Materials Res

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Recent advances in life science technology have prompted the need to develop microcapsule delivery systems that can encapsulate many different functional or active materials such as drugs, peptides, and live cells, etc. The encapsulation technology is now commonly used in medicine, agriculture, food, and other many fields. The application of biodegradable microcapsule systems can not only effectively prevent the degradation of core materials in the body or the biological environment, but also improve the bioavailability, control the release and prolong the halftime or storage of core active materials. Various wall materials, preparation methods, encapsulation processes, and release mechanisms are covered in this review, as well as several main factors including pH values, temperatures, particle sizes, and additives, which can strongly influence the encapsulation efficiency, the strength, and release of microcapsules. The improvement of coating materials, preparation techniques, and challenges are also highlighted, as well as application prospects. K E Y W O R D Scontrolled release, encapsulation efficiency, microcapsules, preparation method, wall material

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Section: Ph Valuesmentioning

confidence: 86%

Section: Natural Polymersmentioning

confidence: 99%

Section: Ph Valuesmentioning

confidence: 99%

Section: Factors Effects Referencesmentioning

confidence: 99%

See 2 more Smart Citations

Recent progress in preparation and agricultural application of microcapsules

Teng

Mao

et al. 2019

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Microencapsulation focused on protecting the active ingredients from volatilizing and oxidizing, and masking the odour or taste of encapsulated materials, which is favourable for achieving immobilization, protection, controlled release, structuration and functionalization of critical element . The main methods used for encapsulation are spray drying, coacervation, polymerization, membrane emulsification, layer assembly and microfluidics . Currently, spray drying is still the most popular technique for microencapsulation as a result of rather economic and straightforward, and has been widely applied in the food and flavour industry .…”

Section: Introductionmentioning

confidence: 99%

Preparation and release mechanism of lavender oil microcapsules with different combinations of coating materials

Zhang

Huang

Xiong

et al. 2019

Flavour & Fragrance J

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The aim of the work was to control morphology and release of lavender oil (LO) microcapsules produced using spray drying through different combination of coating materials (gum acacia, sodium caseinate, gelatin, chitosan, β‐cyclodextrin and polyvinyl alcohol). In addition, the properties of LO microcapsules including encapsulating efficiency (EE), loading capacity, mean particle size and morphology were characterized. Results displayed that the ternary formulations showed higher EE than the pure and binary mixtures; meantime, employment of pure gum acacia indicated the worse encapsulation efficiency. Images from scanning electron microscopy (SEM) showed that morphology of microcapsules has better sphericity because of the presence of polyvinyl alcohol, which illustrated that polyvinyl alcohol might be contributed to surface modification of particles. Furthermore, the release mechanism was described as two stages: burst release and diffusion. And four release models were mainly used to reveal the release mechanism of microcapsules in diffusion process. In most cases, the release of LO microcapsules was dominant by Fickian diffusion except particles prepared from gum acacia—polyvinyl alcohol and gum acacia—sodium caseinate—polyvinyl alcohol.

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TME‐Responsive Polyprodrug Micelles for Multistage Delivery of Doxorubicin with Improved Cancer Therapeutic Efficacy in Rodents

Zhang

Zhu

et al. 2020

Adv Healthcare Materials

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It is of great significance to develop multifunctional biomaterials to effectively deliver anticancer drug to tumor cells for cancer therapy. Here, inspired by the specific tumor microenvironment (TME) cues, a unique multistage pH/redox‐responsive polyprodrug composed of amphiphilic pH‐sensitive diblock copolymer poly(ethylene glycol) methyl ether‐b‐poly(β‐amino esters) conjugated with doxorubicin (DOX) via redox‐sensitive disulfide bonds (mPEG‐b‐PAE‐ss‐DOX) is designed and developed. This polyprodrug can self‐assemble into micelles (DOX‐ss@PMs) at low concentration with high serum stability, indicating that DOX‐ss@PMs have prolonged circulation time. The dual pH/redox‐responsiveness of the multistage platform is thoroughly evaluated. In vitro results demonstrate that DOX‐ss@PMs can highly accumulate at tumor site, followed by responding to the acidity for disassembly and effectively penetrating into the tumor cells. DOX is released from the platform due to the cleavage of disulfide bonds induced by high glutathione (GSH) concentration, thereby inducing the apoptosis of tumor cells. In vivo studies further reveal that multistage DOX‐ss@PMs can more efficiently inhibit the growth of tumors and improve the survival of tumor‐bearing mice in comparison to the free drug and control. These results imply that multistage delivery system might be a potential and effective strategy for drug delivery and DOX‐ss@PMs could be a promising nanomedicine for cancer chemotherapy.

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Drug release of yolk/shell microcapsule controlled by pH-responsive yolk swelling

Cited by 36 publications

References 45 publications

Recent progress in preparation and agricultural application of microcapsules

Recent progress in preparation and agricultural application of microcapsules

Preparation and release mechanism of lavender oil microcapsules with different combinations of coating materials

TME‐Responsive Polyprodrug Micelles for Multistage Delivery of Doxorubicin with Improved Cancer Therapeutic Efficacy in Rodents

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