Drug release kinetics from monolayer films of glucose-sensitive microgel

Li, Xiuting; Luo, Qiaofang; Guan, Ying; Zhang, Yongjun

doi:10.1016/j.polymer.2010.04.011

Cited by 66 publications

(53 citation statements)

References 39 publications

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“…Their hallmark characteristics include large surface areas for functionalization, highly porous interior networks for drug loading, and easy tailoring of their geometry and surface morphology [22–24]. In contrast to organic or inorganic nanoparticles, hydrogels are soft materials which have elastic moduli ranging from 0.1 kPa to 100 kPa mimicking the elasticities of living cells and tissues and can regulate their bioactivities in vitro and in vivo [25–27].…”

Section: Introductionmentioning

confidence: 99%

Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes

et al. 2017

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We report a novel delivery platform for a highly potent anticancer drug, 7-(benzylamino)-3,4-dihydro-pyrrolo[4,3,2-de]quinolin-8(1H)-one (BA-TPQ), using pH- and redox-sensitive poly(methacrylic acid) (PMAA) hydrogel cubes of micrometer size as the encapsulating matrix. The hydrogels are obtained upon cross-linking PMAA with cystamine in PMAA/poly(N-vinylpyrrolidone) multilayers assembled within mesoporous sacrificial templates. The BA-TPQ-loaded hydrogels maintain their cubical shape and pH-sensitivity after lyophilization, which is advantageous for long-term storage. Conversely, the particles degrade in vitro in the presence of glutathione (5 mM) providing 80% drug release within 24 h. Encapsulating BA-TPQ into hydrogels significantly increases its transport via Caco-2 cell monolayers used as a model for oral delivery where the apparent permeability of BA-TPQ-hydrogel cubes was ~2-fold higher than that of BA-TPQ. BA-TPQ-hydrogel cubes exhibit better anticancer activity against HepG2 (IC50=0.52 μg/mL) and Huh7 (IC50=0.29 μg/mL) hepatoma cells with a 40% decrease in the IC50 compared to the non-encapsulated drug. Remarkably, non-malignant liver cells have a lower sensitivity to BA-TPQ-hydrogel cubes with 2-fold increased IC50 values compared to those of cancer cells. In addition, encapsulating BA-TPQ in the hydrogels amplifies the potency of the drug via down-regulation of MDM2 oncogenic protein and upregulation of p53 (a tumor suppressor) and p21 (cell proliferation suppressor) expression in HepG2 liver cancer cells. Moreover, enhanced inhibition of MDM2 protein expression by BA-TPQ-hydrogel cubes is independent of p53-status in Huh7 cells. This drug delivery platform of non-spherical shape provides a facile method for encapsulation of hydrophobic drugs and can facilitate the enhanced efficacy of BA-TPQ for liver cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes

et al. 2017

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“…In recent years, extensive efforts have been made to develop glucose‐sensitive microgels for the treatment of diabetes mellitus . Glucose oxidase, concanavalin A, and phenylboronic acid (PBA) are commonly used as glucose sensor in these materials .…”

Section: Microgels For Drug Delivery Applicationmentioning

confidence: 99%

Functional Microgels: Recent Advances in Their Biomedical Applications

Agrawal

2018

Small

120

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Here, a spotlight is shown on aqueous microgel particles which exhibit a great potential for various biomedical applications such as drug delivery, cell imaging, and tissue engineering. Herein, different synthetic methods to develop microgels with desirable functionality and properties along with degradable strategies to ensure their renal clearance are briefly presented. A special focus is given on the ability of microgels to respond to various stimuli such as temperature, pH, redox potential, magnetic field, light, etc., which helps not only to adjust their physical and chemical properties, and degradability on demand, but also the release of encapsulated bioactive molecules and thus making them suitable for drug delivery. Furthermore, recent developments in using the functional microgels for cell imaging and tissue regeneration are reviewed. The results reviewed here encourage the development of a new class of microgels which are able to intelligently perform in a complex biological environment. Finally, various challenges and possibilities are discussed in order to achieve their successful clinical use in future.

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“…The change in release profile upon addition of d -Glu was, however, strongly dependent on the type of immobilization since the added negative charges counteract the thermally induced “squeezing-out” of the drug. The chemically immobilized ARS showed an increase of release through competitive binding with the added saccharide while the physically loaded FITC-Insulin showed a decrease in release due to the swelling of the polymeric microgel caused by electrostatic repulsion [42]. …”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

Responsive Boronic Acid-Decorated (Co)polymers: From Glucose Sensors to Autonomous Drug Delivery

Vancoillie

Hoogenboom

2016

Sensors

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Boronic acid-containing (co)polymers have fascinated researchers for decades, garnering attention for their unique responsiveness toward 1,2- and 1,3-diols, including saccharides and nucleotides. The applications of materials that exert this property are manifold including sensing, but also self-regulated drug delivery systems through responsive membranes or micelles. In this review, some of the main applications of boronic acid containing (co)polymers are discussed focusing on the role of the boronic acid group in the response mechanism. We hope that this summary, which highlights the importance and potential of boronic acid-decorated polymeric materials, will inspire further research within this interesting field of responsive polymers and polymeric materials.

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Drug release kinetics from monolayer films of glucose-sensitive microgel

Cited by 66 publications

References 39 publications

Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes

Highly efficient delivery of potent anticancer iminoquinone derivative by multilayer hydrogel cubes

Functional Microgels: Recent Advances in Their Biomedical Applications

Responsive Boronic Acid-Decorated (Co)polymers: From Glucose Sensors to Autonomous Drug Delivery

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