Drug release from various thicknesses of layered mats consisting of electrospun polycaprolactone and polyethylene oxide micro/nanofibers

Kim, GeunHyung; Yoon, Hun‐Young; Park, YunKyung

doi:10.1007/s00339-010-5785-y

Cited by 40 publications

(32 citation statements)

References 14 publications

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“…The influence of the strike time t s on the filament lifetime t fil was investigated for CPyCl/NaSal and CTAB/NaSal solutions covering both viscosity maxima, and t s was varied between t s ¼ 20 ms and t s ¼ 160 ms. Longer strike times are not recommended because of a potential superposition of filament stretching and capillary thinning [Sachsenheimer et al (submitted)]. However, no variations of the filament lifetime were found within experimental error in contrast to the observations of Miller et al (2009) who reported a significant influence of t s and h f on the filament lifetime but in good agreement with the results of Kim et al (2010) who could not recover an influence of initial step-strain parameters on the elongational relaxation time.…”

Section: Resultsmentioning

confidence: 62%

“…Recently, extensional rheology of WLM has been investigated using continuous filament stretching [Filament stretching extensional rheometer (FiSER)] or capillary thinning (CaBER) experiments [Rothstein (2003); Yesilata et al (2006); Bhardwaj et al (2007b); Bhardwaj et al (2007a); Chellamuthu and Rothstein (2008);Miller et al (2009);Kim et al (2010); Sachsenheimer et al (submitted)] which allow for applying a purely extensional flow field to these low viscosity liquids. Yesilata et al (2006) have used the CaBER method to measure the extensional behavior of erucyl bis(hydroxyethyl)methylammonium chloride (EHAC) and isopropanol in a brine of ammonium chloride in deionized water.…”

Section: Elongational Flow Of Wlm Solutionsmentioning

confidence: 99%

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Elongational deformation of wormlike micellar solutions

Sachsenheimer

Oelschlaeger

Müller

et al. 2014

Journal of Rheology

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We have investigated the uniaxial elongation behavior of six different wormlike micelle systems covering a broad range of surfactant concentrations cs and salt/surfactant ratios R using the capillary breakup elongational rheometry (CaBER). In the fast-breaking limit (high cs and R), filament lifetime tfil is controlled by the equilibrium shear modulus G0 and the breakage time λbr obtained from small oscillatory shear according to tfil/G0∝λbr2/3 and relaxation time ratios λe/λs≈1 are found. When reptation dominates (high cs, low R) λe/λs<1 is observed similar as for solutions of covalently bound polymers. In this concentration regime, the micellar structure seems not to be affected by the strong elongational flow. In contrast, high filament lifetimes up to 1000 s and λe/λs values up to 10 are observed at low cs irrespective of R. This indicates the formation of elongation-induced structures (EISs). A minimum viscosity and a minimum initial diameter are required for creating EIS. Additional filament stretching experiments indicate that a critical total deformation has to be exceeded for structure build-up. Finally, our experiments reveal a distinct difference regarding the dependence between solutions of linear and branched micelles of filament lifetime on viscosity suggesting that CaBER is a versatile means to distinguish between these structures.

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Section: Resultsmentioning

confidence: 62%

Section: Elongational Flow Of Wlm Solutionsmentioning

confidence: 99%

Elongational deformation of wormlike micellar solutions

Sachsenheimer

Oelschlaeger

Müller

et al. 2014

Journal of Rheology

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“…[31][32][33] Chen et al 31 prepared biodegradable sandwichstructured nanofibers from poly(D,L)-lactide-co-glycolide and collagen with incorporated vancomycin, gentamicin, and lidocaine. They described the conditions of nanofibrous mat preparation by classical jet electrospinning and the in vitro release of the drugs, as well as their effect on the in vivo healing process in rat wounds.…”

Section: Introductionmentioning

confidence: 99%

“…They described the conditions of nanofibrous mat preparation by classical jet electrospinning and the in vitro release of the drugs, as well as their effect on the in vivo healing process in rat wounds. Kim et al 32 observed rhodamine and peptide release from multi-layered PCL/polyethylene oxide/PCL nanofibers. They found a decrease of the initial burst release with increasing thickness of the covering layer and a slower release of compounds from sandwiches with thicker covering layers.…”

Section: Introductionmentioning

confidence: 99%

Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses

Širc¹,

Kubinová²,

Hobzová³

et al. 2012

IJN

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Polyvinyl alcohol nanofibers incorporating the wide spectrum antibiotic gentamicin were prepared by Nanospider™ needleless technology. A polyvinyl alcohol layer, serving as a drug reservoir, was covered from both sides by polyurethane layers of various thicknesses. The multilayered structure of the nanofibers was observed using scanning electron microscopy, the porosity was characterized by mercury porosimetry, and nitrogen adsorption/desorption measurements were used to determine specific surface areas. The stability of the gentamicin released from the electrospun layers was proved by high-performance liquid chromatography (HPLC) and inhibition of bacterial growth. Drug release was investigated using in vitro experiments with HPLC/MS quantification, while the antimicrobial efficacy was evaluated on Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. Both experiments proved that the released gentamicin retained its activity and showed that the retention of the drug in the nanofibers was prolonged with the increasing thickness of the covering layers.

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“…PCL is also commonly utilized in long-term implantable devices [8]. Poly(lactic acid) (PLA) is mostly used in various biomedical applications, benefiting from its biodegradability, good mechanical properties, and biocompatibility [9,10].…”

Section: Introductionmentioning

confidence: 99%

Electrospun PLA: PCL composites embedded with unmodified and 3-aminopropyltriethoxysilane (ASP) modified halloysite nanotubes (HNT)

et al. 2012

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Electrospinning is a simple and versatile fiber synthesis technique in which a highvoltage electric field is applied to a stream of polymer melt or polymer solution, resulting in the formation of continuous micro/nanofibers. Halloysite nanotubes (HNT) have been found to achieve improved structural and mechanical properties when embedded into various polymer matrices. This research work focuses on blending poly(ε-caprolactone) (PCL) (9 wt%/v and 15 wt%/v) and poly(lactic acid) (PLA) (fixed at 8 wt%/v) solutions with HNT at two different concentrations 1 wt%/v and 2 wt%/v. Both unmodified HNT and HNT modified with 3-aminopropyltriethoxysilane (ASP) were utilized in this study. Furthermore, the addition of HNT-ASP to the polymeric blends resulted in a moderate decrease in the degree of crystallinity, as well as slight reductions of glass transition temperature of PCL, the crystallization temperature and melting temperature of PLA within composite materials. The infrared spectra of composites confirmed the successful embedding of HNT-ASP into PLA: PCL nanofibers relative to unmodified HNT due to the premodification using ASP to reduce the agglomeration behavior. This study provides a new material system that could be potentially used in drug delivery, and may facilitate good control of the drug release process.

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Drug release from various thicknesses of layered mats consisting of electrospun polycaprolactone and polyethylene oxide micro/nanofibers

Cited by 40 publications

References 14 publications

Elongational deformation of wormlike micellar solutions

Elongational deformation of wormlike micellar solutions

Controlled gentamicin release from multi-layered electrospun nanofibrous structures of various thicknesses

Electrospun PLA: PCL composites embedded with unmodified and 3-aminopropyltriethoxysilane (ASP) modified halloysite nanotubes (HNT)

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