Drug release from injectable depots: two different in vitro mechanisms

Structure formation in injectable poly(lactide‐co‐glycolide) depots. II. Nature of the gel

“…In the previous articles, 11,12 we had shown that the Resomer RG502/BB solution exhibited a complex flow behavior influenced by both gelation and degradation during aging and in vitro (upon injection into buffer). In this article, we report on the flow behavior of different polymers with different L/G ratios and from different manufacturers.…”

“…In our previous work, 11,12 we studied a novel thermoreversible gel. This gel was formed from a solution of poly-(lactide-co-glycolide) (PLGA) with an L/G ratio of 50:50 dissolved in benzyl benzoate (BB).…”

Controlled release and interaction of protein using self‐assembling peptide RATEA16 nanofiber hydrogels

“…[1][2][3][4][5][6] An increasing therapeutic efficiency can be realized by incorporating controlled release strategies into the design of drug carriers. [7][8][9][10][11][12] At present, some studies on bioactive particles interaction with and release from self-assembling hydrogels under elastic and reversible deformation are reported. When compared with chemically synthesized polymer materials, using peptides as the molecular building blocks for self-assembly offers the possibility of incorporating biofunctionality, such as ligand recognition, biocompatibility, and biodegradability, into the material, 13 and the corresponding hydrogels would respond to external environment under various physiological conditions.…”

Preparation of Parenteral in situ Gel Formulation Based on smart PLGA polymer: Concepts to Decrease Initial Drug Burst and extend drug release

“…D'Souza et al reported that release from PLGA is initially diffusion-controlled followed by a degradation/erosion-controlled final stage [28]. Wang et al also illustrated a two-phase release profile for metoclopramide and its salt (monohydrochloride) from PLGA/benzyl benzoate solutions following injection into buffer: an early diffusion, followed by erosion [29].…”

“…Wang et al also reported the same interpretation for metoclopramide release with PLGA prepared in different solvents. The NMP/PLGA system showed the fastest release, followed by triacetin which migrated into the buffer phase more slowly and finally benzyl benzoate due to its limited water solubility [29]. Ahmed et al studied the release of haloperidol from four different solvents: NMP, DMSO (used as water-miscible), triacetin and ethyl acetate (selected as partially watermiscible).…”