Drug Release from Electric-Field-Responsive Nanoparticles

Ge, Jun; Neofytou, Evgenios; Cahill, Thomas J.; Beygui, Ramin E.; Zare, Richard N.

doi:10.1021/nn203430m

Cited by 456 publications

(332 citation statements)

References 32 publications

Supporting

Mentioning

329

Contrasting

Unclassified

Order By: Relevance

“…For instance, nanoparticles based on conductive polypyrrole exhibited tailored drug-release profiles as a result of a synergistic process of electrochemical reduction-oxidation and electric-field-driven movement of charged molecules. 160 Zhao et al 161 developed a tunable pH and electro-responsive drug release system based on chitosan-capped MSN. IB-loaded MSNs (IB-MSNs) were dispersed in chitosan solution and co-deposited with chitosan hydrogel on a titanium plate.…”

Section: Electro-responsive Drug Deliverymentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

197

View full text Add to dashboard Cite

Section: Electro-responsive Drug Deliverymentioning

confidence: 99%

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Song

et al. 2016

IJN

197

View full text Add to dashboard Cite

“…Various types of drug release devices, such as hydrogel, 1,2 nano-particles, 3,4 and membrane-based reservoir devices, [5][6][7][8] have been extensively studied in literature. Among them, pulsatile drug delivery systems (PDDS) have drawn attention as they allow repeatable and reliable drug release flux for clinical needs.…”

Section: Introductionmentioning

confidence: 99%

Programmable and on-demand drug release using electrical stimulation

Sun

et al. 2015

Biomicrofluidics

View full text Add to dashboard Cite

Recent advancement in microfabrication has enabled the implementation of implantable drug delivery devices with precise drug administration and fast release rates at specific locations. This article presents a membrane-based drug delivery device, which can be electrically stimulated to release drugs on demand with a fast release rate. Hydrogels with ionic model drugs are sealed in a cylindrical reservoir with a separation membrane. Electrokinetic forces are then utilized to drive ionic drug molecules from the hydrogels into surrounding bulk solutions. The drug release profiles of a model drug show that release rates from the device can be electrically controlled by adjusting the stimulated voltage. When a square voltage wave is applied, the device can be quickly switched between on and off to achieve pulsatile release. The drug dose released is then determined by the duration and amplitude of the applied voltages. In addition, successive on/off cycles can be programmed in the voltage waveforms to generate consistent and repeatable drug release pulses for on-demand drug delivery. V C 2015 AIP Publishing LLC.

show abstract

“…Few studies have explored the triggered release of nanoparticles mediated by an electric field [28,29]. In this study, we developed electroresponsive nanoparticles and demonstrated that the triggered-release of PHT from our system was sensitive to an electric field in vitro (as fast as 1 min).…”

Section: Discussionmentioning

confidence: 84%

Electroresponsive Nanoparticles Improve Antiseizure Effect of Phenytoin in Generalized Tonic-Clonic Seizures

et al. 2016

View full text Add to dashboard Cite

Previously, we developed electroresponsive hydrogel nanoparticles (ERHNPs) modified with angiopep-2 (ANG) to facilitate the delivery of the antiseizure drug phenytoin sodium (PHT). However, the electroresponsive characteristics were not verified directly in epileptic mice and the optimal preparation formula for electroresponsive ability is still unclear. Here, we further synthesized PHT-loaded ANG-ERHNPs (ANG-PHT-HNPs) and PHT-loaded nonelectroresponsive hydrogel nanoparticles (ANG-PHTHNPs) by changing the content of sodium 4-vinylbenzene sulfonate in the preparation formulae. In vivo microdialysis analysis showed that ANG-PHT-ERHNPs not only have the characteristics of a higher distribution in the central nervous system, but also have electroresponsive ability, which resulted in a strong release of nonprotein-bound PHT during seizures.In both electrical-(maximal electrical shock) and chemicalinduced (pentylenetetrazole and pilocarpine) seizure models, ANG-PHT-ERHNPs lowered the effective therapeutic doses of PHT and demonstrated the improved antiseizure effects compared with ANG-PHT-HNPs or PHT solution. These results demonstrate that ANG-ERHNPs are able to transport PHT into the brain efficiently and release them when epileptiform activity occurred, which is due to the content of sodium 4-vinylbenzene sulfonate in formula. This may change the therapeutic paradigm of existing drug treatment for epilepsy into a type of on-demand control for epilepsy in the future.

show abstract

Drug Release from Electric-Field-Responsive Nanoparticles

Cited by 456 publications

References 32 publications

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Programmable and on-demand drug release using electrical stimulation

Electroresponsive Nanoparticles Improve Antiseizure Effect of Phenytoin in Generalized Tonic-Clonic Seizures

Contact Info

Product

Resources

About