Drug release from coronary eluting stents: A multidomain approach

Vairo, Giuseppe; Cioffi, Margherita; Cottone, Riccardo; Dubini, Gabriele; Migliavacca, Francesco

doi:10.1016/j.jbiomech.2010.01.033

Cited by 76 publications

(69 citation statements)

References 43 publications

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“…This restriction may inhibit transport across the layer, leading to accumulation of macromolecules in the inner wall. Transport properties of the medial layer are also important in understanding the transport of drugs from stents (Vairo et al, 2010, Denny et al, 2012, Cutri et al, 2013, Bozsak et al, 2014.…”

Section: Introductionmentioning

confidence: 99%

A combined numerical and experimental framework for determining permeability properties of the arterial media

Comerford

Chooi

Nowak

et al. 2014

Biomech Model Mechanobiol

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The medial layer of the arterial wall may play an important role in the regulation of water and solute transport across the wall. In particular, a high medial resistance to transport could cause accumulation of lipid carrying molecules in the inner wall. In this study, the water transport properties of medial tissue were characterised in a numerical model utilising experimentally obtained data for the medial microstructure and the relative permeability of di↵erent constituents. For the model, a new solver for flow in porous materials, based on a high-order splitting scheme, was implemented in the spectral/hp element library nektar++ and validated. The data were obtained by immersing excised aortic bifurcations in a solution of fluorescent protein tracer and subsequently imaging them with a confocal microscope. Cuboidal regions of interest were selected in which the microstructure and relative permeability of di↵erent structures were transformed to a computational mesh. Impermeable objects were treated fictitiously in the numerical scheme. On this cube, a pressure drop was applied in the three coordinate directions and the principal components of the permeability tensor were determined. The reconstructed images demonstrated the arrangement of elastic lamellae and interspersed smooth muscle cells in rat aortic media; the distribution and alignment of the smooth muscle cells varied spatially within the extracellular matrix. The numerical simulations high-

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Section: Introductionmentioning

confidence: 99%

A combined numerical and experimental framework for determining permeability properties of the arterial media

Comerford

Chooi

Nowak

et al. 2014

Biomech Model Mechanobiol

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“…A number of three-dimensional models have also been devised. (Weiler et al, 2012) provided a broad generalization of the works of (Mongrain et al, 2007), (Zunino et al, 2009) and (Vairo et al, 2010); a three-dimensional model of drug transport in the lumen and the arterial wall. Laminar steady flow was assumed in the lumen and the steady diffusion equation (no convection) in the arterial wall.…”

Section: Higher-dimensional Modelsmentioning

confidence: 99%

Simulating Drug-eluting Stents - Progress Made and the Way Forward

McGinty¹,

McCormick²,

McKee³

et al. 2013

Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications

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Abstract:Drug-eluting stents have significantly improved the treatment of coronary artery disease. Compared with their bare metal predecessors, they offer reduced rates of restenosis and thus represent the current gold standard in percutaneous coronary interventions. Drug-eluting stents have been around for over a decade, and while progress is continually being made, they are not suitable in all patients and lesion types. Furthermore there are still real concerns over incomplete healing and late stent thrombosis. In this paper, some modelling approaches are reviewed and the future of modelling and simulation in this field is discussed.

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“…Computational models for the in silico ana lysis of drug delivery from drug-eluting stents Relevant in silico studies of drug delivery from DESs Several computational models were studied to analyze drug delivery from DESs, developing ad hoc transient mass-transfer models, both in 2D [3][4][5] and 3D [6][7][8].…”

Section: Concerns Related To Des Implantationmentioning

confidence: 99%

“…Evaluation of the causes of fluctuations in drug deposition can improve understanding of the effective local drug elution. A more recent study also considered the presence of a polymeric coating loaded with a drug and the effect of local hemodynamics on drug delivery, by analyzing drug release with a multidomain approach [5]. This work focused attention on the differences in drug distribution due to the stent structure, strongly influencing convective drug flow.…”

Section: Concerns Related To Des Implantationmentioning

confidence: 99%