Drug release from a surface erosion biodegradable viscoelastic polymeric platform: Analysis and numerical simulation

Azhdari, Ebrahim; Emami, Aram; Ferreira, J. A.

doi:10.1016/j.camwa.2020.10.010

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…Exponent n is usually used to characterize four types of transport of active molecules through the matrix [ 7 ], which describes the kinetic and mechanism of OMC release. When n ≤ 0.43, the major driving force is the Fickian diffusion, if n is in the range of 0.43 and 0.85, the release mechanism is the diffusion and the swelling and n = 0.85 indicates zero order release kinetics, and n > 0.85 demonstrates Super Case-II transport [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

“…It was a promising technology to encapsulate OMC for overcoming the trans-epidermal penetration and promoting UV absorption ability. Complex coacervation, as one kind of microencapsulation technology, is accomplished by phase separation of one or many hydrocolloids from the initial solution and the subsequent deposition of the newly formed coacervate phase around the active ingredient which has been used widely to microencapsulate the active components [ 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Sunscreen Enhancement of Octyl Methoxycinnamate Microcapsules by Using Two Biopolymers as Wall Materials

Zeng

Yang

et al. 2021

Polymers

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Octyl methoxycinnamate (OMC) is widely used as a chemical sunscreen in sunscreen cosmetics. However, its direct contact with the skin would bring certain risks, such as skin photosensitive reaction. How to improve the effect of skin photodamage protection has become a current research hotspot. Encapsulating ultraviolet (UV) filters into microcapsules is an interesting method to increase the photostability of filters. In this study, sodium caseinate (SC) and arabic gum (GA) are chosen as wall materials to prepare synergistic sunscreen microcapsules by complex coacervation technology. A series of experiments are conducted to investigate the effects of pH, wall material concentration, and wall/core ratio on the formation of OMC microcapsules. The morphology, composition, and stability of OMC microcapsules are characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The OMC microcapsule is uniform in size distribution, smooth in surface morphology, and has good thermal stability. The results show that the ultraviolet absorption of the OMC microcapsules is better than that of the uncoated OMC for the ultraviolet-B (280–320 nm). Moreover, the OMC microcapsule released 40% in 12 h, while OMC released 65%, but the sun protection factor (SPF) of the OMC microcapsule sunscreen is 18.75% higher than that of OMC. This phenomenon may be attributed to the hydrophobic interaction between SC and OMC and the electrostatic interaction between SC and GA.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sunscreen Enhancement of Octyl Methoxycinnamate Microcapsules by Using Two Biopolymers as Wall Materials

Zeng

Yang

et al. 2021

Polymers

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“…The predominant mechanisms governing drug release from polymeric matrices typically comprise diffusion, erosion, and swelling, with the prevalence of a particular mechanism contingent upon the nature of the polymer employed [58,59]. Hydrophilic polymer-based matrices enable liberation of the drug load through the ingress of water into the system [60], a process often sensitive to temperature variations and transitions from a glassy to a matrix relaxation state. Consequently, in such matrices, the phenomena of swelling and diffusion frequently manifest.…”

Section: Drug Release and Release Kinetics Of Optimized Formulationmentioning

confidence: 99%

A Novel Intrauterine Device for the Spatio-Temporal Release of Norethindrone Acetate as a Counter-Estrogenic Intervention in the Genitourinary Syndrome of Menopause

Abdelgader,

Govender,

Kumar

et al. 2024

Pharmaceutics

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The genitourinary syndrome of menopause (GSM) is a widely occurring condition affecting millions of women worldwide. The current treatment of GSM involves the use of orally or vaginally administered estrogens, often with the risk of endometrial hyperplasia. The utilization of progestogens offers a means to counteract the effects of estrogen on the endometrial tissue, decreasing unwanted side effects and improving therapeutic outcomes. In this study, a norethindrone acetate (NETA)-loaded, hollow, cylindrical, and sustained release platform has been designed, fabricated, and optimized for implantation in the uterine cavity as a counter-estrogenic intervention in the treatment of GSM. The developed system, which comprises ethyl cellulose (EC) and polycaprolactone (PCL), has been statistically optimized using a two-factor, two-level factorial design, with the mechanical properties, degradation, swelling, and in vitro drug release of NETA from the device evaluated. The morphological characteristics of the platform were further investigated through scanning electron microscopy in addition to cytocompatibility studies using NIH/3T3 cells. Results from the statistical design highlighted the platform with the highest NETA load and the EC-to-PCL ratio that exhibited favorable release and weight loss profiles. The drug release data for the optimal formulation were best fitted with the Peppas–Sahlin model, implicating both diffusion and polymer relaxation in the release mechanism, with cell viability results noting that the prepared platform demonstrated favorable cytocompatibility. The significant findings of this study firmly establish the developed platform as a promising candidate for the sustained release of NETA within the uterine cavity. This functionality serves as a counter-estrogenic intervention in the treatment of GSM, with the platform holding potential for further advanced biomedical applications.

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“…This control has resulted in positive treatment outcomes for many diseases including cancer due to the improved pharmacokinetics and pharmacodynamics of nanocarriers compared to those of drugs alone. − The surface morphology of nanocarriers plays a significant role in the controlled delivery of therapeutics. For noncovalently bound drugs, the release occurs due to the diffusion gradient of drug molecules away from the nanocarrier and into the bulk solution . The variables that affect drug release include a number of physicochemical properties such as material chemistry, surface roughness, uniformity, hydrophobicity, and interactions with therapeutic molecules. − …”

Section: Introductionmentioning

confidence: 99%

“…For noncovalently bound drugs, the release occurs due to the diffusion gradient of drug molecules away from the nanocarrier and into the bulk solution. 5 The variables that affect drug release include a number of physicochemical properties such as material chemistry, surface roughness, uniformity, hydrophobicity, and interactions with therapeutic molecules. 6−8 Nucleic acids are attractive nanomaterials due to their ease of controllable assembly, unique mechanical properties, stimuli responsiveness, and ability to deliver drug payloads.…”

Section: ■ Introductionmentioning

confidence: 99%

Tailored Nucleic Acid Architectures at Gold Surfaces for Controlled Therapeutic Release

et al. 2022

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Nucleic acids are versatile materials capable of forming smart nanocarriers with highly controllable therapeutic delivery. DNA-gated release is a mechanism by which DNA oligonucleotides physically block the release of encapsulated drugs from porous nanoparticles. We extend this mechanism to be used with drugs bound to the surface of DNA-capped gold nanoparticles (AuNPs). We investigated DNA monolayers of different thicknesses and hybridization states to determine how DNA surface architecture can affect the release of a template drug bound to the gold surface. DNA layers are investigated on the planar gold surface via quartz crystal microbalance with dissipation and on AuNPs via dynamic light scattering. The resultant layer architectures were studied for their effect on the release rate of drugs. We observed that varying DNA architectures on AuNPs result in different release rates of the drug. The rate of drug release can be slowed using either folded or randomly coiled DNA sequences, which act as a physical barrier to diffusion. DNA monolayers with upright orientation release drugs more quickly. When the longer single-stranded DNA is used, the drug release is slowed even further. However, even upright DNA layers provide a barrier to drug diffusion at longer sequence lengths. We hypothesize that it is the architecture of the DNA layer, influenced by the folded or upright orientation of individual DNA molecules, that affects the free diffusion of the drug away from the AuNP surface. This mechanism may improve the biological availability of many surface-bound drugs on solid, DNA-capped nanoparticles.

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Drug release from a surface erosion biodegradable viscoelastic polymeric platform: Analysis and numerical simulation

Cited by 3 publications

References 23 publications

Sunscreen Enhancement of Octyl Methoxycinnamate Microcapsules by Using Two Biopolymers as Wall Materials

Sunscreen Enhancement of Octyl Methoxycinnamate Microcapsules by Using Two Biopolymers as Wall Materials

A Novel Intrauterine Device for the Spatio-Temporal Release of Norethindrone Acetate as a Counter-Estrogenic Intervention in the Genitourinary Syndrome of Menopause

Tailored Nucleic Acid Architectures at Gold Surfaces for Controlled Therapeutic Release

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