Drug release from a N-vinylpyrrolidinone/acrylic acid lubricious hydrophilic coating

Devine, Declan M.; Geever, Luke M.; Higginbotham, Clement L.

doi:10.1007/s10853-005-0416-2

Cited by 19 publications

(12 citation statements)

References 25 publications

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“…This decrease in swelling percentage with variation in molecular weight was due to the shortening in distance between crosslinks for the lower molecular weight PEGDMA 400; causing the hydrogel to imbibe less aqueous solution. These findings are in agreement with those of Devine and Higginbotham [23] who observed similar outcomes when using PEGDMA as a crosslinking agent for Polyvinylpyrrolidinone/polyacrylic acid systems, where hydrogels containing higher molecular weight crosslinker exhibited higher water contents in the equilibrium swollen state [43].…”

Section: Differential Scanning Calorimetrysupporting

confidence: 91%

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

et al. 2012

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Hydrogels formulated from single polymers are often insufficient in terms of their mechanical properties for use as bone substitute materials. Hence, hydrogels synthesised from combinations of polymers have been investigated to optimise the performance of such materials. In the current study, polypropylene glycol dimethacrylate was added to polyethylene glycol dimethacrylate of a variety of molecular weights and photopolymerised to form a series of hydrogels. Polyethylene glycol and polypropylene glycol have the same chemical structure with the exception of a methyl group on the later. Herein, the influence of the methyl group of polypropylene glycol on the mechanical properties of hydrogels for bone regeneration applications is reported. For both unconfined and cyclic compression testing, results demonstrated that the incorporation of PEGDMA into the precursor improves the compression strength of the hydrogels. For example, in unconfined compression tests the Young's modulus varied between 6.62 ± 0.31 MPa and 8.08 ± 0.81 MPa with the incorporation of PEGDMA 400.

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Section: Differential Scanning Calorimetrysupporting

confidence: 91%

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

et al. 2012

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“…An important property of a medical device, especially urethral catheters, ureteral stents, and peripherally inserted central catheters, is the ease with which it can be inserted and removed after required function has been performed. 8 Recently, plasma has become a very useful method for surface modification. Such a low-friction surface would enable easy insertion and removal from a patient.…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of PVC Film with Allylamine Plasma Polymers

2014

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In this study, surface modifications of poly(vinyl chloride) (PVC) films were performed with the plasma polymerization process. For this purpose, allylamine was used as a hydrophilic polymer for surface modification of PVC films. The wettability of PVC films was investigated using contact angle measurement. The water contact angle values increased from 116.4°to 12°by 104.4°for the coated PVC film. Surface free energies of PVC films were calculated using acid-base approaches and increased with increasing plasma treatment time. According to the Fourier transform infrared spectroscopy results, N-H peaks appeared in the expected wavelength. The thermal degradation behaviors of PVC films were investigated by thermogravimetric analysis. The degradation temperature of PVC films was altered by the plasma treatment from 275°C to 380°C. Surface topography of PVC films was examined by atomic force microscopy (AFM). Distinct changes were observed in the topography of plasma-treated PVC surface using AFM results. The results showed that allylamine plasma treatment can be used to enhance hydrophilicity of PVC surfaces. C

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“…In recent years, our research group has been dedicated towards developing new and improved hydrogels for potential biomedical applications by synthesising and modifying both stimuli sensitive and biocompatible hydrogels [12][13][14][15][16][17][18][19][20]. The aim of this work was to prepare temperature-sensitive hydrogels that exhibit a high water uptake, pulsatile swelling and sharp thermosensitivity in the vicinity of physiological temperature, via a UV-initiated polymerisation process.…”

Section: Introductionmentioning

confidence: 99%

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

et al. 2012

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Novel thermo-sensitive N,N-diethylacrylamide (DEAAm) based copolymer hydrogels were prepared via UV-induced free radical bulk polymerisation. UV polymerisation was employed to avoid the use of potentially toxic solvents; solution polymerisation has been the most common means for the preparation of PDEAAm-based hydrogels in the literature to date. The resultant hydrogels were analysed using nuclear magnetic resonance, Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. Parameters such as the crosslinking degree and the nature of the incorporated hydrophilic component, N-vinyl-2-pyrrolidone (NVP) or N,N-dimethylacrylamide (DMAAm) were found to impact hydrogel structure, mechanical properties and swelling kinetics. Pulsatile swelling studies indicated that the hydrogels had thermo-reversible properties which were greatly affected by test temperature, nature of hydrophilic monomer used and crosslinker content. Aminophylline was selected as a model solute for drug loading and release studies by thermal deswelling in HCl buffer (pH 1.4) and phosphate buffer media (pH 6.8). The observed lag time prior to significant drug release from the more crosslinked P(DEAAm-NVP) hydrogels could make them suitable for delayed specific release in the intestine and potential alternatives to layers or membranes in timespecific and site-specific swelling-controlled drug delivery systems.

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Drug release from a N-vinylpyrrolidinone/acrylic acid lubricious hydrophilic coating

Cited by 19 publications

References 25 publications

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration

Surface Modification of PVC Film with Allylamine Plasma Polymers

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

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