Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox

Abstract

The release of API from polymeric nanoparticles contributes profoundly to the in vivo-performance of drug delivery devices in the gastrointestinal tract. The impact of drug-polymer interaction and particle size was analyzed. Sustained release of TMP-001 could only be achieved by increasing particle size. Therefore, biorelevant release testing has been demonstrated to be a valid tool for nanoformulation design.

LOEWE Workshop Particle Characterization in Medicine and Biology

“…As a first step, he illustrated the importance of drug release testing for drug delivery applications. He presented a study of particle uptake in Caco2 and T-84 cells [5]. The delivery system effectively permeated the artificial mucus barrier and entered the cells but released 100% of its payload after few minutes within the gastrointestinal tract [5].…”

“…He presented a study of particle uptake in Caco2 and T-84 cells [5]. The delivery system effectively permeated the artificial mucus barrier and entered the cells but released 100% of its payload after few minutes within the gastrointestinal tract [5]. He also highlighted the implications for in vitro-in vivo correlation and explained how insensitive in vitro measurements impair the predictions made with in silico methods [6,7].…”