Drug release and solubility properties of two zeolitic metal–organic frameworks influenced by their hydrophobicity/hydrophilicity

Abstract

Metal–organic frameworks (MOFs) have shown significant potential for drug delivery applications. However, there remains a scarcity of comprehensive research addressing the influence of surface properties of MOFs on drug release...

Mitochondrial topoisomerase 1 targeted anticancer therapy using irinotecan encapsulated mesoporous MIL-101(Fe) synthesized via a vapour assisted method

“…12–15 But MOFs have evolved as an extremely potential carrier for drug delivery due to the several outstanding advantages of these materials, such as (1) an exceptionally high surface area and porosity so that a large amount of drugs can be loaded, (2) the nontoxic effect of MOFs due to the moderate strength of the coordination bond, which makes MOFs biodegradable, (3) convenient surface modification by predesigning post-synthetic strategies so that their physiochemical properties can be modified, (4) well defined structures of MOFs so that further host–guest interactions can be studied, (5) easy diffusion of substrates to interact with the incorporated drug via their open pore window. Several families of interesting MOFs have been reported in the last two decades including Materials Institute Lavoisier (MILs), 16 iso-reticular metal–organic frameworks (IR-MOFs), 17 porous coordination networks (PCNs), 18 zeolitic imidazole frameworks (ZIFs), 19 porous coordination polymers (PCPs), etc . 20 Progressive research on the rationalization of the fundamental understanding of cancer therapy has been directed with the help of a large number of organic polymers 21 and metal organic frameworks (MOFs) 22 for targeting and treating cancer cells.…”