Drug-Related Problems and Hospital Admissions in Cardiac Transplant Recipients

Repp, K.; Hayes, Charles H.; Woods, T. Mark; Allen, Keith B.; Kennedy, Kevin F.; Borkon, Michael

doi:10.1345/aph.1r094

Cited by 17 publications

(41 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study reported that 40% (19 of 48) of read-missions in patients who had previously received a heart transplant were caused by DRPs and that 58% (11 of 19) of these were preventable. 16 These values are closer to those observed in our study.…”

Section: Discussionsupporting

confidence: 91%

“…A study of 97 patients with heart failure found that one of the most frequent DRP detected (22%) involved inadequate dose, regimen, or duration of a drug, 7 while a study of 19 heart transplant recipients who were readmitted for a DRP found that the most common cause was an inappropriate dose (47.4%). 16 In our study, dose adjustment according to renal function was more frequent in patients with heart failure than in those with other cardiovascular diseases. In contrast, prescription errors caused by inadequate knowledge of the CPOE were less frequent in patients with heart failure than in those with other cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 48%

“…Similarly, a study of 1,857 patients with chronic heart failure reported that female patients were less frequently treated with required drugs, such as angiotensin converting-enzyme inhibitors or angiotensin II receptor blockers, and were less frequently prescribed adequate doses of β-blockers. 15 In contrast, other studies have found no relationship between age or sex and the frequency of DRP in heart transplant recipients, 16 or between demographic variables and a higher number of drugs in patients with heart failure. 3 …”

Section: Discussionmentioning

confidence: 93%

See 2 more Smart Citations

Patient risk factors for developing a drug-related problem in a cardiology ward

Urbina¹,

Ferrández²,

Luque³

et al. 2014

TCRM

View full text Add to dashboard Cite

BackgroundBecause of the high incidence of drug-related problems (DRPs) among hospitalized patients with cardiovascular diseases and their potential impact on morbidity and mortality, it is important to identify the most susceptible patients, who therefore require closer monitoring of drug therapy.PurposeTo identify the profile of patients at higher risk of developing at least one DRP during hospitalization in a cardiology ward.MethodWe consecutively included all patients hospitalized in the cardiology ward of a teaching hospital in 2009. DRPs were identified through a computerized warning system designed by the pharmacy department and integrated into the electronic medical record.ResultsA total of 964 admissions were included, and at least one DRP was detected in 29.8%. The variables associated with a higher risk of these events were polypharmacy (odds ratio [OR]=1.228; 95% confidence interval [CI]=1.153–1.308), female sex (OR=1.496; 95% CI=1.026–2.180), and first admission (OR=1.494; 95% CI=1.005–2.221).ConclusionMonitoring patients through a computerized warning system allowed the detection of at least one DRP in one-third of the patients. Knowledge of the risk factors for developing these problems in patients admitted to hospital for cardiovascular problems helps in identifying the most susceptible patients.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Patient risk factors for developing a drug-related problem in a cardiology ward

Urbina¹,

Ferrández²,

Luque³

et al. 2014

TCRM

View full text Add to dashboard Cite

show abstract

“…This could be attributed to the fact that prospective studies allowed closer contact with the patients, which permitted more complete and accurate information to be obtained . In addition, the prospective studies used a wide variety of definitions for ADRs, which comprised not only WHO definitions , but also other definitions based on hazards, harm and poison prediction or classification of ADR types [29–30]. Similar to the retrospective studies, the severity and preventability were under‐reported.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of hospitalization resulting from medicine‐related problems in adult patients

Hamid

Ghaleb

Aljadhey

et al. 2014

Brit J Clinical Pharma

162

143

View full text Add to dashboard Cite

AIMSMedicine-related problems (MRPs) represent a major issue leading to hospitalization, especially in adult and elderly patients. The aims of this review are to investigate the prevalence, causes and major risk factors for MRPs leading to hospitalization in adult patients and to identify the main medicine classes involved. METHODSStudies were identified through electronic searches of Medline, Embase, Scopus and International Pharmaceutical Abstracts between January 2000 and May 2013. A systematic review was conducted of both retrospective and prospective studies. Studies included were those involving hospitalization resulting from MRPs in adults (≥18 years old), whereas studies excluded were those investigating drug misuse and abuse and studies investigating MRPs in hospitalized patients. Data analysis was performed using SPSS version 20. RESULTSForty-five studies were identified, including 21 that investigated hospitalization resulting from adverse drug reactions, six studies that investigated hospitalization due to adverse drug events and 18 studies that investigated hospitalization due to MRPs. The median prevalence rates of hospitalization resulting from adverse drug reactions, adverse drug events and MRPs were 7% (interquartile range, 2.4-14.9%), 4.6% (interquartile range, 2.85-16.6%) and 12.1% (interquartile range, 6.43-22.2%), respectively. The major causes contributing to MRPs were adverse drug reactions and noncompliance. In addition, the major risk factors associated with MRPs were old age, polypharmacy and comorbidities. Moreover, the main classes of medicines implicated were medicines used to treat cardiovascular diseases and diabetes. CONCLUSIONSHospitalization due to MRPs had a high prevalence, in the range of 4.6-12.1%. Most MRPs encountered were prevalent among adult patients taking medicines for cardiovascular diseases and diabetes.

show abstract

“…After reviewing the full text of the articles, only 19 were finally selected [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. The main reasons for exclusion are summarized in Fig.…”

Section: Review Of Information and Definition Of Scenariosmentioning

confidence: 99%