Drug-related problems and determinants among elective surgical patients: A prospective observational study

Adem, Fuad; Bayissa, Bodena; Getachew, Mestawet

doi:10.1177/20503121221122438

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…The pharmacophore model functions as a virtual template in ligand-based drug discovery, facilitating the process of screening, and choosing prospective drug candidates. Substrates that correspond to the predetermined characteristics of the pharmacophore are more inclined to demonstrate the intended biological activity (26). By employing this methodology, it becomes possible to logically devise innovative AGIs with an emphasis on molecular interactions that are crucial for achieving potent inhibitory effects.…”

Section: Discussionmentioning

confidence: 99%

Integrative computational approaches for designing novel alpha-glucosidase inhibitors based on curculigoside A derivatives: Virtual screening, molecular docking, and molecular dynamics

Asnawi,

Mieldianisa,

Aligita

et al. 2024

J Herbmed Pharmacol

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Introduction: Over 422 million people worldwide suffer from diabetes, causing 1.5 million fatalities annually. The existing medications have shortcomings, including poor glucose control and adverse effects. The present study aimed to create possible alpha-glucosidase inhibitors utilizing a curculigoside A derivative ligand-based model. Methods: A pharmacophore model was constructed utilizing the structure information of curculigoside A derivatives and PharmaGist. Subsequently, virtual screening, molecular docking, and molecular dynamics were employed to simulate the hits. Results: From six training sets, eleven pharmacophore models were developed; the model with the highest score (18.0435) was chosen for further analysis. Using the verified pharmacophore model, 270 547 chemicals from the ZINC natural product database were subjected to virtual screening. Subsequently, molecular docking was performed on the top 1000 hits with AutoDock Wizard from PyRx. This analysis unveiled 434 hits with better binding energies than acarbose, the native ligand. Subsequently, second optimal docking configurations were evaluated with AutoDock 2.4; this process yielded the discovery of three prospective inhibitors (ZINC000150350051, ZINC000008382292, and ZINC000085595291) characterized by the most advantageous binding energies. To evaluate the stability and dynamics of these ligand-receptor complexes, Gromacs 2022 molecular dynamics simulations were executed for one hundred nanoseconds. Out of the three hits, ZINC000085595291 (Hit03) exhibited good energy components and interaction stability constantly during the simulation. Conclusion: The integrated computational strategy identified promising alpha-glucosidase inhibitors in curculigoside A compounds, highlighting the potential of ZINC000085595291 (Hit03) as a potential diabetes therapeutic agent.

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Section: Discussionmentioning

confidence: 99%

Integrative computational approaches for designing novel alpha-glucosidase inhibitors based on curculigoside A derivatives: Virtual screening, molecular docking, and molecular dynamics

Asnawi,

Mieldianisa,

Aligita

et al. 2024

J Herbmed Pharmacol

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“…Hal yang sama juga terjadi pada penelitian lain,dalam studi tentang DRPs pada pasien operasi elektif (Mohammed et al, 2022), Setidaknya satu masalah DRPs terjadi saat dirawat di rumah sakit, Pemberian antibiotik lain tanpa indikasi merupakan faktor utama penyebab DRPs pada penggunaan antibiotik profilaksis yang disebabkan karena pemberian antibiotik terapeutik pasca operasi, sedangkan pasien dengan operasi bersih dianjurkan profilaksis tanpa antibiotik pasca operasi (Bassetti et al, 2015;Mohammed et al, 2022). Penggunaan antibiotik yang tidak bijak merupakan kontributor utama munculnya strain mikroba resisten (Sahile et al, 2016;Tefera et al, 2019).…”

Section: Pembahasanunclassified

Drug Related Problems (DRPs) Penggunaan Antibiotik Profilaksis pada Bedah Ortopedi

Reiza,

Cholisoh

2024

Mal Health Stu J.

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Drug Related Problems (DRPs) are treatment conditions that cause or have the potential to interfere with clinical outcomes and result in therapy failure. The use of prophylactic antibiotics often experiences inaccuracies that cause DRPs. The aim of this research was to determine the problems and causes of DRPs in the use of prophylactic antibiotics in clean orthopedic surgery patients using a retrospective approach. The inclusion criteria applied were clean orthopedic surgery patients aged >18 years. and exclusion criteria are patients with Diabetes Mellitus, immune diseases, and other infectious diseases and age > 60 years. The use of prophylactic antibiotics was analyzed based on the Regulation of the Minister of Health of the Republic of Indonesia concerning Guidelines for the Use of Antibiotics and then classified with PCNE V9.1. Of 264 medical records of orthopedic patients with clean surgery, the highest choice of prophylactic antibiotic therapy was ceftriaxone at 49.6%. The highest DRPs problems are related to safety issues (P2) 48.4% in the form of potentially harmful drugs occurring (P2.1), other problems (P3) 40% related to unnecessary drug administration (P3.1) and effectiveness 10.6% related to effects medication is not optimal (P1.2). The highest cause of DRPs, drug selection factor (C1) 67% (no drug indication (C1.2) = 36.7%, drug selection not in accordance with guidelines (C1.1) = 30.3%), drug use factor (C6) 24.9% in the form of an inappropriate administration time (C6.1), and dose selection factor (C3) 8.1% in the form of an inappropriate dose (C3.1). Keywords: Antibiotics, Prophylaxis, DRPs, PCNE, Orthopedics Surgery ABSTRAK Drug Related Problems (DRPs) merupakan kondisi pengobatan yang menyebabkan atau berpotensi mengganggu hasil klinis hingga kegagalan terapi. Penggunaan antibiotik profilaksis seringkali mengalami ketidaktepatan yang menyebabkan terjadinya DRPs. Penelitian dilakukan bertujuan untuk mengetahui masalah dan penyebab terjadinya DRPs penggunaan antibiotik profilaksis pada pasien operasi bersih ortopedi dengan pendekatan retrospektif. Kriteria inklusi diterapkan yaitu pasien operasi bersih ortopedi yang usia >18 tahun. dan kriteria eksklusi adalah pasien dengan Diabetes Mellitus, penyakit imunitas, dan penyakit infeksi lainnya serta usia >60 tahun. Penggunaan antibiotik profilaksis dianalisis berdasarkan Peraturan Menteri Kesehatan Republik Indonesia tentang Pedoman Penggunaan Antibiotik kemudian diklasifikasikan dengan PCNE V9.1. Dari 264 rekam medik pasien ortopedi dengan tindakan operasi bersih, pemilihan terapi antibiotik profilaksis tertinggi adalah ceftriaxone sebesar 49,6%. Masalah DRPs tertinggi terkait masalah keamanan (P2) 48,4% berupa obat merugikan berpotensi terjadi (P2.1), masalah lain (P3) 40% terkait pemberian obat yang tidak perlu (P3.1) dan efektivitas 10,6% terkait efek obat tidak optimal (P1.2). Penyebab DRPs tertinggi, faktor pemilihan obat (C1) 67% (tidak adanya indikasi obat (C1.2) = 36,7%, pemilihan obat yang tidak sesuai dengan pedoman (C1.1) = 30,3%),faktor penggunaan obat (C6) 24,9% berupa waktu pemberian yang tidak sesuai (C6.1), dan faktor pemilihan dosis (C3) 8,1% berupa dosis yang tidak tepat (C3.1). Kata Kunci: Antibiotik, Profilaksis, DRPs, PCNE, Operasi Ortopedi

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“…Perioperative pain, nausea and vomiting, anticoagulation, anti-infection, blood pressure management, blood glucose management, nutrition management, fluid management and other aspects are all considered in medication therapy, as well as problems related to medication therapy. However, drug-related problems (DRPs) are common among hospitalized patients, potentially leading to morbidity, mortality, and increased treatment costs [ 6 , 7 , 8 , 9 , 10 ]. Patients attending surgical wards are especially at risk due to the need for pain medication, antibiotics, and frequent adjustments of antithrombotic regimens [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, drug-related problems (DRPs) are common among hospitalized patients, potentially leading to morbidity, mortality, and increased treatment costs [ 6 , 7 , 8 , 9 , 10 ]. Patients attending surgical wards are especially at risk due to the need for pain medication, antibiotics, and frequent adjustments of antithrombotic regimens [ 8 ]. Mohammed et al, reported that up to 69.5% of patients had at least one DRP during their hospital stay among elective surgical patients [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Patients attending surgical wards are especially at risk due to the need for pain medication, antibiotics, and frequent adjustments of antithrombotic regimens [ 8 ]. Mohammed et al, reported that up to 69.5% of patients had at least one DRP during their hospital stay among elective surgical patients [ 8 ]. In addition, polypharmacy is increasingly prevalent in older patients [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Surgical Pharmacy for Optimizing Medication Therapy Management Services within Enhanced Recovery after Surgery (ERAS®) Programs

Xie

Huang

Gao

et al. 2023

JCM

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Drug-related problems (DRPs) are common among surgical patients, especially older patients with polypharmacy and underlying diseases. DRPs can potentially lead to morbidity, mortality, and increased treatment costs. The enhanced recovery after surgery (ERAS) system has shown great advantages in managing surgical patients. Medication therapy management for surgical patients (established as “surgical pharmacy” by Guangdong Province Pharmaceutical Association (GDPA)) is an important part of the ERAS system. Improper medication therapy management can lead to serious consequences and even death. In order to reduce DRPs further, and promote the rapid recovery of surgical patients, the need for pharmacists in the ERAS program is even more pressing. However, the medication therapy management services of surgical pharmacy and how surgical pharmacists should participate in ERAS programs are still unclear worldwide. Therefore, this article reviews the main perioperative medical management strategies and precautions from several aspects, including antimicrobial agents, antithrombotic agents, pain medication, nutritional therapy, blood glucose monitoring, blood pressure treatment, fluid management, treatment of nausea and vomiting, and management of postoperative delirium. Additionally, the way surgical pharmacists participate in perioperative medication management, and the relevant medication pathways are explored for optimizing medication therapy management services within the ERAS programs. This study will greatly assist surgical pharmacists’ work, contributing to surgeons accepting that pharmacists have an important role in the multidisciplinary team, benefitting medical workers in treating, counseling, and advocating for their patients, and further improving the effectiveness, safety and economy of medication therapy for patients and promoting patient recovery.

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Drug-related problems and determinants among elective surgical patients: A prospective observational study

Cited by 6 publications

References 16 publications

Integrative computational approaches for designing novel alpha-glucosidase inhibitors based on curculigoside A derivatives: Virtual screening, molecular docking, and molecular dynamics

Integrative computational approaches for designing novel alpha-glucosidase inhibitors based on curculigoside A derivatives: Virtual screening, molecular docking, and molecular dynamics

Drug Related Problems (DRPs) Penggunaan Antibiotik Profilaksis pada Bedah Ortopedi

Surgical Pharmacy for Optimizing Medication Therapy Management Services within Enhanced Recovery after Surgery (ERAS®) Programs

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