Drug related negative side-effects is a common reason for poor compliance in hormone replacement therapy

Björn, Inger; Backstrom, T.

doi:10.1016/s0378-5122(99)00018-3

Cited by 68 publications

(28 citation statements)

References 21 publications

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“…Post-menopausal women are typically treated with E 2 -based HT that are augmented with progestins (not P 4 alone) to minimize trophic effects in the endometrium [35,40]. However, about a third of women discontinuing HT do so because of negative mood effects [2]. The two main factors that predict unfavorable response to progestins are the preparation of the HT and prior negative responses to HT.…”

Section: Rotarodmentioning

confidence: 99%

Progesterone enhances performance of aged mice in cortical or hippocampal tasks

Frye

Walf

2008

Neuroscience Letters

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Ovarian steroids alter cognitive performance of young individuals. Whether progesterone enhances learning and memory in tasks involving the prefrontal cortex and/or hippocampus in aged mice was investigated. Aged mice received progesterone (10 mg/kg, SC) or vehicle and were tested for cortical and/or hippocampal learning and memory. Progesterone increased spontaneous alterations in the Tmaze and time spent exploring novel objects in the object recognition task. Progesterone increased the time mice spent in the quadrant of the water maze where the hidden platform had been during training, increased latencies to crossover to the shock-associated side of the inhibitory avoidance chamber, and increased freezing in the contextual fear conditioning task. Progesterone did not enhance performance in tasks mediated by the amygdala (cued conditioning), striatum (conditioned place preference), or cerebellum (rotarod) in these aged mice. Thus, progesterone improved learning and memory in tasks mediated by the prefrontal cortex and/or hippocampus of aged mice. KeywordsCognition; Learning; Memory; Estrogen Variations in cognitive performance of female rodents over reproductive cycles coincide with changes in levels of hormones, such as 17β-estradiol (E 2 ) and progesterone (P 4 ). Rats in behavioral estrus, compared to diestrus, have higher levels of E 2 and P 4 and perform better in inhibitory avoidance, trace conditioning, object recognition and placement tasks [9,26,39,41], but not active avoidance or water maze tasks [6,8]. Pregnant rats' performance in the water maze task is enhanced when E 2 and P 4 levels are escalating (1st and 2nd trimester), not declining (3rd trimester), compared to non-pregnant rats [18]. Thus, changes in endogenous hormones influence cognitive performance. E 2 and P 4 administration can improve cognitive performance of rodents. E 2 improves cognitive performance of young and aged rodents across a variety of tasks, but these effects are clearly influenced by age and the dosing/regimen utilized [4]. P 4 to young, middle-aged, or aged E 2 -primed rats or mice improves cognitive performance in several tasks [10,12,20,22,27,28].P 4 , independent of E 2 , may improve cognitive behavior. Chronic low-dose P 4 , or acute administration of P 4 , prior to training in the water maze improves performance of young, ovariectomized (ovx) rats [12]. P 4 post-training to ovx rats enhances performance in the object recognition, delayed-non-matching-to-sample, and inhibitory avoidance tasks, when rats were tested 24 h later when P 4 levels are at nadir [10]. Thus, physiological levels of P 4 , independent of E 2 , may enhance learning and memory of young adult rodents.

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Section: Rotarodmentioning

confidence: 99%

Progesterone enhances performance of aged mice in cortical or hippocampal tasks

Frye

Walf

2008

Neuroscience Letters

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“…In a Swedish study, 30% of the women stated that they experienced a negative mood effect during HT and 35% stated side effects as a reason for discontinuing HT 33 . Therefore providing information about progestagens in a manner adapted to women's knowledge is of utmost importance to ensure adherence to treatment.…”

Section: Knowledge In Relation To Ht Usementioning

confidence: 99%

Knowledge of reproductive physiology and hormone therapy in 53- to 54-year-old Swedish women

Lindh-Åstrand

Brynhildsen²,

Hoffmann³

et al. 2007

Menopause

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Knowledge of reproductive physiology and hormone therapy in 53-to 54-year-old Swedish women: a population-based study., 2007, Menopause, (14) Women with low educational level were more likely to answer the questions by stating that they were unsure than did women with high educational level. Ever users of HT knew more than never-users about risks and benefits of HT in relation to breast cancer and osteoporosis, and ever-users thought that the risks of thrombosis and myocardial infarction were lower than did never-users. Conclusions:Women need improved knowledge of the risks and benefits of HT as well as education about the reproductive system around menopause. This would probably better support and empower menopausal women to manage an important period of their lives.

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“…Several studies reported that up to 50% of postmenopausal women were not adherent to their treatment after one to 5 years of HRT (114)(115)(116)(117)(118). A major cause of non-compliance were unwanted side-effects or fear of side-effects, inconvenience caused by medication, and high drug costs (119,120). Hence, monitoring patients on antiresorptive medication is an eminent part of patient management in order to improve adherence and persistence to therapy, and ultimately treatment effectiveness.…”

Section: Monitoring Patient Compliance Using Bone Markersmentioning

confidence: 99%

Clinical application of biochemical markers of bone turnover

Seibel

2006

Arq Bras Endocrinol Metab

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With the ageing population in most countries, disorders of bone and mineral metabolism are becoming increasingly relevant to every day clinical practice. Consequently, the interest in, and the need for effective measures to be used in the screening, diagnosis and follow-up of such pathologies have markedly grown. Together with clinical and imaging techniques, biochemical tests play an important role in the assessment and differential diagnosis of metabolic bone disease. In recent years, the isolation and characterisation of cellular and extracellular components of the skeletal matrix have resulted in the development of molecular markers that are considered to reflect either bone formation or bone resorption. These biochemical indices are non-invasive, comparatively inexpensive and, when applied and interpreted correctly, helpful tools in the diagnostic and therapeutic assessment of metabolic bone disease. This review provides an overview of the current evidence regarding the clinical use of biochemical markers of bone remodelling in bone disease, with an emphasis on osteoporosis. RESUMO Marcadores Bioquímicos da Remodelação Óssea.Tendo em vista o crescimento da população idosa na maioria dos paí-ses, os distúrbios do metabolismo ósseo e mineral estão tornando-se cada vez mais relevantes na prática clínica diária. Conseqüentemente, o interesse e a necessidade de medidas efetivas para serem usadas no rastreamento, diagnóstico e seguimento de tais patologias vêm crescendo acentuadamente. Além da avaliação clínica e de técnicas de imagens, os marcadores bioquímicos desempenham um importante papel na avaliação e diagnóstico das doenças ósseas metabólicas. Recentemente, a melhor caracterização dos componentes intracelulares e extracelulares da matriz óssea resultou no desenvolvimento dos marcadores moleculares, os quais refletem tanto a formação como a reabsorção óssea. Estes marcadores bioquímicos não são invasivos e comparativamente são de mais baixo custo, e quando aplicados e interpretados corretamente são instrumentos úteis no diagnóstico e tratamento das doenças ósseas metabólicas. Esta revisão abordará evidências atuais, levando em consideração o uso clínico dos marcadores bioquímicos da remodelação óssea nas doenças metabólicas ósseas, com ênfase na osteoporose.

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Drug related negative side-effects is a common reason for poor compliance in hormone replacement therapy

Cited by 68 publications

References 21 publications

Progesterone enhances performance of aged mice in cortical or hippocampal tasks

Progesterone enhances performance of aged mice in cortical or hippocampal tasks

Knowledge of reproductive physiology and hormone therapy in 53- to 54-year-old Swedish women

Clinical application of biochemical markers of bone turnover

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