Drug-related deaths in a university central hospital

Juntti‐Patinen, Laura; Neuvonen, Pertti J.

doi:10.1007/s00228-002-0501-2

Cited by 97 publications

(7 citation statements)

References 21 publications

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“…Knopf and Du reported an ADR occurrence rate of 0.9 % in a sample of 17,450 German children (outpatient setting, self-reported ADRs) [ 51 ]. The study that reported ADRs as a cause of death used intensive chart review to identify ADRs that contributed to the death of all patients who died during a 1-year period in a Finnish hospital (1511 deaths) [ 54 ]. They reported that 5 % of all deaths were caused by an ADR and that 0.05 % of all hospitalizations resulted in a fatal ADR [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

“…The study that reported ADRs as a cause of death used intensive chart review to identify ADRs that contributed to the death of all patients who died during a 1-year period in a Finnish hospital (1511 deaths) [ 54 ]. They reported that 5 % of all deaths were caused by an ADR and that 0.05 % of all hospitalizations resulted in a fatal ADR [ 54 ]. This is in line with all studies (Tables 1 , 2 , 3 , 4 ) that reported the rate of fatal ADRs.…”

Section: Resultsmentioning

confidence: 99%

“…Fifty percent (11/22) of all in-hospital ADR occurrence studies reported the rate of fatal ADRs; in four studies, no fatal ADRs were reported, and the highest fatal ADR rate was 0.52 % of all hospitalized patients. One other article reported that 0.05 % of all patients admitted during a 1-year period in a university hospital died of an ADR (5 % of all ADRs) [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of Adverse Drug Reactions in Europe: A Review of Recent Observational Studies

2015

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Adverse drug reactions (ADRs) cause considerable mortality and morbidity but no recent reviews are currently available for the European region. Therefore, we performed a review of all epidemiological studies quantifying ADRs in a European setting that were published between 1 January 2000 and 3 September 2014. Included studies assessed the number of patients who were admitted to hospital due to an ADR, studies that assessed the number of patients who developed an ADR during hospitalization, and studies that measured ADRs in the outpatient setting. In total, 47 articles were included in the final review. The median percentage of hospital admissions due to an ADR was 3.5 %, based on 22 studies, and the median percentage of patients who experienced an ADR during hospitalization was 10.1 %, based on 13 studies. Only five studies were found that assessed ADRs occurring in the outpatient setting. These results indicate that the occurrence of ADRs in the European hospital setting—both ADRs that result in hospitalization and ADRs that occur during the hospital stay—is significant. Furthermore, the limited number of studies that were performed in the outpatient setting identify a lack of information regarding the epidemiology of ADRs in this setting.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epidemiology of Adverse Drug Reactions in Europe: A Review of Recent Observational Studies

2015

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“…ADRs are a major cause of morbidity and place a substantial burden on limited healthcare resources [2]. Multiple factors influence ADR susceptibility, including multiple drug therapy, disease severity, age, and the type and number of drugs prescribed [3-8].…”

Section: Introductionmentioning

confidence: 99%

Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil

Lobo¹,

Pinheiro

Castro

et al. 2013

BMC Pharmacol Toxicol

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BackgroundAdverse drug reactions (ADRs) are recognised as a common cause of hospital admissions, and they constitute a significant economic burden for hospitals. Hospital-based ADR monitoring and reporting programmes aim to identify and quantify the risks associated with the use of drugs provided in a hospital setting. This information may be useful for identifying and minimising preventable ADRs and may enhance the ability of prescribers to manage ADRs more effectively. The main objectives of this study were to evaluate ADRs that occurred during inpatient stays at the Hospital Geral de Palmas (HGP) in Tocantins, Brazil, and to facilitate the development of a pharmacovigilance service.MethodsA prospective study was conducted at HGP over a period of 8 months, from January 2009 to August 2009. This observational, cross-sectional, descriptive study was based on an analysis of medical records. Several parameters were utilised in the data evaluation, including patient demographics, drug and reaction characteristics, and reaction outcomes. The reaction severity and predisposing factors were also assessed.ResultsThe overall incidence of ADRs in the patient population was 3.1%, and gender was not found to be a risk factor. The highest ADR rate (75.8%) was found in the adult age group 15 to 50 years, and the lowest ADR rate was found in children aged 3 to 13 years (7.4%). Because of the high frequency of ADRs in orthopaedic (25%), general medicine (22%), and oncology (16%) patients, improved control of the drugs used in these specialties is required. Additionally, the nurse team (52.7%) registered the most ADRs in medical records, most likely due to the job responsibilities of nurses. As expected, the most noticeable ADRs occurred in skin tissues, with such ADRs are more obvious to medical staff, with rashes being the most common reactions. Metamizole, tramadol, and vancomycin were responsible for 21, 11.6, and 8.4% of ADRs, respectively. The majority of ADRs had moderate severity (58.9%), thus requiring intervention. Type A reactions were the most common (82.1%). At least one predisposing factor was present in 79.9% of the reports examined, and the most common predisposing factor was polypharmacy.ConclusionsThe results obtained will contribute to the development of strategies for the pharmacovigilance service at HGP and other hospitals throughout the country, which will improve the quality of ADR reporting and ensure safer drug use in Brazilian hospitals.

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“…Adverse drug reactions (ADRs) and adverse drug events (ADEs) are involved in nearly 100,000 deaths in the United States of America each year, [1,2] and may have accounted for 5% of inpatient deaths [3] in a Swedish hospital. In France, a nationwide survey revealed that the incidence of severe ADEs during hospitalization is 7.6 per 1000 inpatient days [4]; of these, three severe ADEs per 1000 inpatient days may be preventable.…”

Section: Introductionmentioning

confidence: 99%

Adverse drug events with hyperkalaemia during inpatient stays: evaluation of an automated method for retrospective detection in hospital databases

Ficheur

Chazard

Beuscart

et al. 2014

BMC Med Inform Decis Mak

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Background: Adverse drug reactions and adverse drug events (ADEs) are major public health issues. Many different prospective tools for the automated detection of ADEs in hospital databases have been developed and evaluated. The objective of the present study was to evaluate an automated method for the retrospective detection of ADEs with hyperkalaemia during inpatient stays. Methods: We used a set of complex detection rules to take account of the patient's clinical and biological context and the chronological relationship between the causes and the expected outcome. The dataset consisted of 3,444 inpatient stays in a French general hospital. An automated review was performed for all data and the results were compared with those of an expert chart review. The complex detection rules' analytical quality was evaluated for ADEs.

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Drug-related deaths in a university central hospital

Cited by 97 publications

References 21 publications

Epidemiology of Adverse Drug Reactions in Europe: A Review of Recent Observational Studies

Epidemiology of Adverse Drug Reactions in Europe: A Review of Recent Observational Studies

Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil

Adverse drug events with hyperkalaemia during inpatient stays: evaluation of an automated method for retrospective detection in hospital databases

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