“…Research to resolve these issues of causation may be currently beyond the power of science to conduct, although qualitative research can suggest potential pathways. Research into possible pathways that might connect these macro-level processes with changes in HIV and mortality is also needed, and our team has been involved in research with individual, metropolitan and other levels of spatial analysis and in research to develop measures to study other pathways (Cooper et al, 2011, 2012a, 2012b, 2016; Friedman, Sandoval, et al, 2013; Friedman, Pouget, Sandoval, Jones, & Mateu-Gelabert, 2015; Friedman, Pouget, Sandoval, Jones, Nikolopoulos, et al, 2015; Nikolopoulos et al, 2015; Pouget, Sandoval, Nikolopoulos, & Friedman, 2015). Research on the time lag between a given macrosocial change and any effects it may have would also be useful.…”