The SUPAC approach enables either an increase or a decrease in production levels to be implemented in response to shifts in customer demand. The rules that apply to these SUPACs are different based on the regulatory agency that oversees the manufacture of the product. In this review, the rules for making USFDA SUPACs have been written out in detail. This study is being conducted with the intention of reducing the amount of time and money required to manage site migrations. More productive results, a faster deployment of tools and methods, and less time spent studying failures are all benefits of this approach. An increase in the pace of uptake, increased batch sizes, a decrease in the production of things that are not yet stable enough for commercial use, and a cost reduction for stability testing are all desirable outcomes.