Drug Prescription Patterns in Schizophrenia Outpatients: Analysis of Data from a German Health Insurance Fund

Weinbrenner, Susanne; Assion, Hans‐Jörg; Stargardt, Tom; Busse, Reinhard; Juckel, Georg; Gericke, Christian A.

doi:10.1055/s-0028-1103293

Cited by 46 publications

(34 citation statements)

References 21 publications

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“…The rates of clozapine prescription for TRS patients found in Brazilian community centers were similar to rates found in studies carried out in the United States 28,29 , an especially low proportion when compared to other countries 26,27,30 . Clozapine was only prescribed for 22 individuals, which represents 21.4% of the TRS patients, or 5% of the total number of schizophrenia patients, despite the abundant evidence of clozapine's superior efficacy and effectiveness compared with other antipsychotic drugs in the treatment of TRS patients 6,7,8,13,31,32 .…”

Section: Discussionsupporting

confidence: 64%

Patterns of clozapine and other antipsychotics prescriptions in patients with treatment-resistant schizophrenia in community mental health centers in São Paulo, Brazil

Silveira¹,

Rocha²,

Àttux³

et al. 2015

Arch. Clin. Psychiatry (São Paulo)

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Background: Despite of its global underuse, clozapine is still the golden standard antipsychotic for patients with treatment-resistant schizophrenia (TRS). Objective: To evaluate the patterns of clozapine and other antipsychotic drugs prescription in TRS in community mental health centers in São Paulo, Brazil. Methods: A multiple-choice questionnaire was applied to fifteen psychiatrists at five centers inquiring about patients' clinical condition, adherence to oral treatment and current antipsychotic treatment. History of previous and current antipsychotic treatment was collected through medical chart review. Results: Out of 442 schizophrenia patients, 103 (23.3%) fulfilled the criteria for TRS. Fifty-eight patients (56.3%) were receiving polypharmacy; 30 (29.1%) were on atypical antipsychotic monotherapy, 14 (13.6%) were on typical antipsychotic monotherapy, 25 (24.3%) were taking depot antipsychotic medication and only 22 (21.4%) were receiving clozapine. Discussion: As well as in other parts of the world, many TRS patients (78.6%) receive other drugs instead of clozapine in São Paulo, the best evidence-based medication for patients with TRS. The government should make every effort to provide medical training and the equipment and logistic support to adequately serve those who could benefit from clozapine treatment at the community health centers.

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Section: Discussionsupporting

confidence: 64%

Patterns of clozapine and other antipsychotics prescriptions in patients with treatment-resistant schizophrenia in community mental health centers in São Paulo, Brazil

Silveira¹,

Rocha²,

Àttux³

et al. 2015

Arch. Clin. Psychiatry (São Paulo)

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“…The most preferred antipsychotic combination was quetiapine plus risperidone [12]. In Germany, it was olanzapine [45] and in Korea, it was risperidone and haloperidol but the monotherapy group was olanzapine. In the UK (2007–2011), the primary care setting most commonly prescribed first- and second-generation antipsychotics: olanzapine, risperidone and chlorpromazine, respectively [46].…”

Section: Discussionmentioning

confidence: 99%

Antipsychotic Use Pattern in Schizophrenia Outpatients: Correlates of Polypharmacy

Yazıcı

Çilli

Yazıcı

et al. 2017

CPEMH

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Background:This study investigates the antipsychotic use patterns of patients with schizophrenia and its correlations in their daily drug use patterns.Methods:Patients with schizophrenia who have regular records at two different community counselling centres (CCS) were included in the study. Information about their medications and sociodemographic data was recorded through face-to-face interviews and supporting information about their drug use patterns was obtained from their relatives/caregivers/nurse. The Clinical Global Impression Scale (severity of illness) and the General Assessment of Functionality scales were also administered.Results:Patients with schizophrenia used 2.0 ± 0.81 antipsychotics daily and 3.52 ± 2.55 pills (1–18). Seventy-one percent of the patients used two or more kinds of psychotropic drugs. The most frequently used antipsychotics were quetiapine, a second generation antipsychotic, and haloperidol, a typical antipsychotic. Clinical severity, regular visits to a CCS and use of depot antipsychotics were independent predictors for polypharmacy.Conclusion:The rate of polypharmacy use is high in Turkey. There are multiple risk factors related with polipharmacy. New studies should focus risk factors for preventing polypharmacy.

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“…While similar studies show that the prevalence of the above mentioned adverse effects was low in patients on fluphenazine and haloperidol. 27,1,29 This difference could be due to the clinician's preferential use of these drugs in patients subsequent to the development of obesity and/or diabetes mellitus following the use of atypical agents.…”

Section: Discussionmentioning

confidence: 99%

“…1 Several publications have indicated that atypical antipsychotic drugs are superior in efficacy to conventional antipsychotic drugs especially with respect to control of negative symptoms and lack of extrapyramidal side effects, these being the limiting factors with the conventional drugs. 2 A study on metabolic syndrome in outpatients receiving antipsychotic therapy by Mainara AS et al has shown that prevalence of metabolic syndrome was significantly higher in subjects on antipsychotics (27.0%) and elevated body mass index was seen in 33.40% of them.…”

Section: Introductionmentioning

confidence: 99%

Pattern of adverse reactions of antipsychotics in a tertiary care hospital

Viswanathan¹,

Sisupalan

Vidhukumar

2016

Int J Basic Clin Pharmacol

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Drug Prescription Patterns in Schizophrenia Outpatients: Analysis of Data from a German Health Insurance Fund

Abstract: At 60%, the proportion of patients in this study treated with atypical antipsychotics was surprisingly high. Of significant interest is the frequent prescription of clozapine (14%). The results are discussed in comparison to comparable studies from other countries.

Cited by 46 publications

References 21 publications

Patterns of clozapine and other antipsychotics prescriptions in patients with treatment-resistant schizophrenia in community mental health centers in São Paulo, Brazil

Patterns of clozapine and other antipsychotics prescriptions in patients with treatment-resistant schizophrenia in community mental health centers in São Paulo, Brazil

Antipsychotic Use Pattern in Schizophrenia Outpatients: Correlates of Polypharmacy

Pattern of adverse reactions of antipsychotics in a tertiary care hospital

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